WALTHAM, MA
UPSTREAM BIO, INC.UPB— Latest position per institution from SEC 13F filings
15
Institutional holders
44.19M
Total shares held
443.35M
Estimated value
2.21M
Avg. position size
FMR LLC
CIK 315066
Shares
8.16M
Value
56.49M
Filed
Jun 30, 2026
ORBIMED ADVISORS LLC
CIK 1055951
Shares
5.69M
Value
39.40M
Filed
Jun 30, 2026
NORGES BANK
CIK 1374170
Shares
3.77M
Value
26.08M
Filed
Jun 30, 2026
BLACKROCK, INC.
CIK 2012383
Shares
3.75M
Value
25.97M
Filed
Jun 30, 2026
DECHENG CAPITAL LLC
CIK 2010850
Shares
2.72M
Value
18.86M
Filed
Jun 30, 2026
ENAVATE SCIENCES GP, LLC
CIK 1953107
Shares
2.46M
Value
17.02M
Filed
Jun 30, 2026
VANGUARD GROUP INC
CIK 102909
Shares
2.39M
Value
64.85M
Filed
Dec 31, 2025
VANGUARD CAPITAL MANAGEMENT LLC
CIK 2100119
Shares
1.88M
Value
12.99M
Filed
Jun 30, 2026
JANUS HENDERSON GROUP LTD.
CIK 1274173
Shares
1.53M
Value
41.42M
Filed
Dec 31, 2025
DEEP TRACK CAPITAL, LP
CIK 1856083
Shares
1.44M
Value
15.84M
Filed
Jun 30, 2025
OMEGA FUND MANAGEMENT, LLC
CIK 1637359
Shares
1.33M
Value
36.01M
Filed
Dec 31, 2025
VENROCK ADVISER, LLC
CIK 1615982
Shares
1.17M
Value
31.75M
Filed
Dec 31, 2025
MILLENNIUM MANAGEMENT LLC
CIK 1273087
Shares
1.14M
Value
7.91M
Filed
Jun 30, 2026
D. E. SHAW & CO., INC.
CIK 1009207
Shares
1.04M
Value
7.17M
Filed
Jun 30, 2026
JPMORGAN CHASE & CO
CIK 19617
Shares
1.01M
Value
7.01M
Filed
Jun 30, 2026
FEDERATED HERMES, INC.
CIK 1056288
Shares
979.76K
Value
8.82M
Filed
Mar 31, 2026
QUBE RESEARCH & TECHNOLOGIES LTD
CIK 1729829
Shares
978.50K
Value
6.77M
Filed
Jun 30, 2026
PARKMAN HEALTHCARE PARTNERS LLC
CIK 1777015
Shares
935.25K
Value
6.47M
Filed
Jun 30, 2026
GEODE CAPITAL MANAGEMENT, LLC
CIK 1214717
Shares
931.26K
Value
6.45M
Filed
Jun 30, 2026
SEB ASSET MANAGEMENT AB
CIK 2127509
Shares
878.47K
Value
6.08M
Filed
Jun 30, 2026
| # | Institution | CIK | Shares | Est. Value | Period |
|---|---|---|---|---|---|
| 1 | FMR LLC | 315066 | 8.16M | 56.49M | Jun 30, 2026 |
| 2 | ORBIMED ADVISORS LLC | 1055951 | 5.69M | 39.40M | Jun 30, 2026 |
| 3 | NORGES BANK | 1374170 | 3.77M | 26.08M | Jun 30, 2026 |
| 4 | BLACKROCK, INC. | 2012383 | 3.75M | 25.97M | Jun 30, 2026 |
| 5 | DECHENG CAPITAL LLC | 2010850 | 2.72M | 18.86M | Jun 30, 2026 |
| 6 | ENAVATE SCIENCES GP, LLC | 1953107 | 2.46M | 17.02M | Jun 30, 2026 |
| 7 | VANGUARD GROUP INC | 102909 | 2.39M | 64.85M | Dec 31, 2025 |
| 8 | VANGUARD CAPITAL MANAGEMENT LLC | 2100119 | 1.88M | 12.99M | Jun 30, 2026 |
| 9 | JANUS HENDERSON GROUP LTD. | 1274173 | 1.53M | 41.42M | Dec 31, 2025 |
| 10 | DEEP TRACK CAPITAL, LP | 1856083 | 1.44M | 15.84M | Jun 30, 2025 |
| 11 | OMEGA FUND MANAGEMENT, LLC | 1637359 | 1.33M | 36.01M | Dec 31, 2025 |
| 12 | VENROCK ADVISER, LLC | 1615982 | 1.17M | 31.75M | Dec 31, 2025 |
| 13 | MILLENNIUM MANAGEMENT LLC | 1273087 | 1.14M | 7.91M | Jun 30, 2026 |
| 14 | D. E. SHAW & CO., INC. | 1009207 | 1.04M | 7.17M | Jun 30, 2026 |
| 15 | JPMORGAN CHASE & CO | 19617 | 1.01M | 7.01M | Jun 30, 2026 |
| 16 | FEDERATED HERMES, INC. | 1056288 | 979.76K | 8.82M | Mar 31, 2026 |
| 17 | QUBE RESEARCH & TECHNOLOGIES LTD | 1729829 | 978.50K | 6.77M | Jun 30, 2026 |
| 18 | PARKMAN HEALTHCARE PARTNERS LLC | 1777015 | 935.25K | 6.47M | Jun 30, 2026 |
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 1214717 | 931.26K | 6.45M | Jun 30, 2026 |
| 20 | SEB ASSET MANAGEMENT AB | 2127509 | 878.47K | 6.08M | Jun 30, 2026 |
Data sourced from SEC Form 13F institutional holdings reports. Positions reflect the most recent filing per institution.