WALTHAM, MA
SPYRE THERAPEUTICS, INC.SYRE— Latest position per institution from SEC 13F filings
15
Institutional holders
64.37M
Total shares held
3.11B
Estimated value
3.22M
Avg. position size
FMR LLC
CIK 315066
Shares
11.78M
Value
594.23M
Filed
Mar 31, 2026
BLACKROCK, INC.
CIK 2012383
Shares
5.52M
Value
278.49M
Filed
Mar 31, 2026
RTW INVESTMENTS, LP
CIK 1493215
Shares
4.17M
Value
210.44M
Filed
Mar 31, 2026
VANGUARD GROUP INC
CIK 102909
Shares
4.04M
Value
132.19M
Filed
Dec 31, 2025
FAIRMOUNT FUNDS MANAGEMENT LLC
CIK 1802528
Shares
4.02M
Value
202.67M
Filed
Mar 31, 2026
PERCEPTIVE ADVISORS LLC
CIK 1224962
Shares
3.78M
Value
190.83M
Filed
Mar 31, 2026
VENROCK ADVISER, LLC
CIK 1615982
Shares
3.69M
Value
185.89M
Filed
Mar 31, 2026
VANGUARD CAPITAL MANAGEMENT LLC
CIK 2100119
Shares
3.06M
Value
154.22M
Filed
Mar 31, 2026
DRIEHAUS CAPITAL MANAGEMENT LLC
CIK 938206
Shares
2.79M
Value
140.77M
Filed
Mar 31, 2026
STATE STREET CORP
CIK 93751
Shares
2.61M
Value
131.50M
Filed
Mar 31, 2026
BLACKROCK FINANCE, INC.
CIK 1364742
Shares
2.40M
Value
56.50M
Filed
Jun 30, 2024
PARADIGM BIOCAPITAL ADVISORS LP
CIK 1855655
Shares
1.96M
Value
98.72M
Filed
Mar 31, 2026
COMMODORE CAPITAL LP
CIK 1831942
Shares
1.91M
Value
96.46M
Filed
Mar 31, 2026
REMEDIUM CAPITAL PARTNERS, LLC
CIK 2104501
Shares
1.91M
Value
96.21M
Filed
Mar 31, 2026
TCG CROSSOVER MANAGEMENT, LLC
CIK 1839948
Shares
1.90M
Value
95.87M
Filed
Mar 31, 2026
TANG CAPITAL MANAGEMENT LLC
CIK 1232621
Shares
1.89M
Value
95.44M
Filed
Mar 31, 2026
WELLINGTON MANAGEMENT GROUP LLP
CIK 902219
Shares
1.82M
Value
92.04M
Filed
Mar 31, 2026
CAPITAL INTERNATIONAL INVESTORS
CIK 1562230
Shares
1.75M
Value
88.07M
Filed
Mar 31, 2026
GEODE CAPITAL MANAGEMENT, LLC
CIK 1214717
Shares
1.72M
Value
86.82M
Filed
Mar 31, 2026
JANUS HENDERSON GROUP PLC
CIK 1274173
Shares
1.66M
Value
83.59M
Filed
Mar 31, 2026
| # | Institution | CIK | Shares | Est. Value | Period |
|---|---|---|---|---|---|
| 1 | FMR LLC | 315066 | 11.78M | 594.23M | Mar 31, 2026 |
| 2 | BLACKROCK, INC. | 2012383 | 5.52M | 278.49M | Mar 31, 2026 |
| 3 | RTW INVESTMENTS, LP | 1493215 | 4.17M | 210.44M | Mar 31, 2026 |
| 4 | VANGUARD GROUP INC | 102909 | 4.04M | 132.19M | Dec 31, 2025 |
| 5 | FAIRMOUNT FUNDS MANAGEMENT LLC | 1802528 | 4.02M | 202.67M | Mar 31, 2026 |
| 6 | PERCEPTIVE ADVISORS LLC | 1224962 | 3.78M | 190.83M | Mar 31, 2026 |
| 7 | VENROCK ADVISER, LLC | 1615982 | 3.69M | 185.89M | Mar 31, 2026 |
| 8 | VANGUARD CAPITAL MANAGEMENT LLC | 2100119 | 3.06M | 154.22M | Mar 31, 2026 |
| 9 | DRIEHAUS CAPITAL MANAGEMENT LLC | 938206 | 2.79M | 140.77M | Mar 31, 2026 |
| 10 | STATE STREET CORP | 93751 | 2.61M | 131.50M | Mar 31, 2026 |
| 11 | BLACKROCK FINANCE, INC. | 1364742 | 2.40M | 56.50M | Jun 30, 2024 |
| 12 | PARADIGM BIOCAPITAL ADVISORS LP | 1855655 | 1.96M | 98.72M | Mar 31, 2026 |
| 13 | COMMODORE CAPITAL LP | 1831942 | 1.91M | 96.46M | Mar 31, 2026 |
| 14 | REMEDIUM CAPITAL PARTNERS, LLC | 2104501 | 1.91M | 96.21M | Mar 31, 2026 |
| 15 | TCG CROSSOVER MANAGEMENT, LLC | 1839948 | 1.90M | 95.87M | Mar 31, 2026 |
| 16 | TANG CAPITAL MANAGEMENT LLC | 1232621 | 1.89M | 95.44M | Mar 31, 2026 |
| 17 | WELLINGTON MANAGEMENT GROUP LLP | 902219 | 1.82M | 92.04M | Mar 31, 2026 |
| 18 | CAPITAL INTERNATIONAL INVESTORS | 1562230 | 1.75M | 88.07M | Mar 31, 2026 |
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 1214717 | 1.72M | 86.82M | Mar 31, 2026 |
| 20 | JANUS HENDERSON GROUP PLC | 1274173 | 1.66M | 83.59M | Mar 31, 2026 |
Data sourced from SEC Form 13F institutional holdings reports. Positions reflect the most recent filing per institution.