WALTHAM, MA
SPYRE THERAPEUTICS, INC.SYRE— Latest position per institution from SEC 13F filings
15
Institutional holders
72.64M
Total shares held
5.66B
Estimated value
3.63M
Avg. position size
FMR LLC
CIK 315066
Shares
13.03M
Value
1.16B
Filed
Jun 30, 2026
BLACKROCK, INC.
CIK 2012383
Shares
6.51M
Value
577.66M
Filed
Jun 30, 2026
PERCEPTIVE ADVISORS LLC
CIK 1224962
Shares
4.32M
Value
383.48M
Filed
Jun 30, 2026
RTW INVESTMENTS, LP
CIK 1493215
Shares
4.25M
Value
377.49M
Filed
Jun 30, 2026
VANGUARD GROUP INC
CIK 102909
Shares
4.04M
Value
132.19M
Filed
Dec 31, 2025
FAIRMOUNT FUNDS MANAGEMENT LLC
CIK 1802528
Shares
4.02M
Value
202.67M
Filed
Mar 31, 2026
PARADIGM BIOCAPITAL ADVISORS LP
CIK 1855655
Shares
3.84M
Value
340.98M
Filed
Jun 30, 2026
VANGUARD CAPITAL MANAGEMENT LLC
CIK 2100119
Shares
3.45M
Value
306.17M
Filed
Jun 30, 2026
STATE STREET CORP
CIK 93751
Shares
3.06M
Value
271.44M
Filed
Jun 30, 2026
VENROCK ADVISER, LLC
CIK 1615982
Shares
2.99M
Value
265.05M
Filed
Jun 30, 2026
PRICE T ROWE ASSOCIATES INC /MD/
CIK 80255
Shares
2.96M
Value
262.87K
Filed
Jun 30, 2026
DRIEHAUS CAPITAL MANAGEMENT LLC
CIK 938206
Shares
2.80M
Value
248.51M
Filed
Jun 30, 2026
GEODE CAPITAL MANAGEMENT, LLC
CIK 1214717
Shares
2.56M
Value
239.26M
Filed
Jun 30, 2026
BLACKROCK FINANCE, INC.
CIK 1364742
Shares
2.40M
Value
56.50M
Filed
Jun 30, 2024
VANGUARD PORTFOLIO MANAGEMENT LLC
CIK 2100121
Shares
2.33M
Value
206.87M
Filed
Jun 30, 2026
CAPITAL WORLD INVESTORS
CIK 1422849
Shares
2.32M
Value
205.57M
Filed
Jun 30, 2026
JUPITER TOPCO LLC
CIK 2146052
Shares
2.21M
Value
195.88M
Filed
Jun 30, 2026
TCG CROSSOVER MANAGEMENT, LLC
CIK 1839948
Shares
1.90M
Value
168.73M
Filed
Jun 30, 2026
TANG CAPITAL MANAGEMENT LLC
CIK 1232621
Shares
1.89M
Value
167.99M
Filed
Jun 30, 2026
BANK OF AMERICA CORP /DE/
CIK 70858
Shares
1.78M
Value
157.84M
Filed
Jun 30, 2026
| # | Institution | CIK | Shares | Est. Value | Period |
|---|---|---|---|---|---|
| 1 | FMR LLC | 315066 | 13.03M | 1.16B | Jun 30, 2026 |
| 2 | BLACKROCK, INC. | 2012383 | 6.51M | 577.66M | Jun 30, 2026 |
| 3 | PERCEPTIVE ADVISORS LLC | 1224962 | 4.32M | 383.48M | Jun 30, 2026 |
| 4 | RTW INVESTMENTS, LP | 1493215 | 4.25M | 377.49M | Jun 30, 2026 |
| 5 | VANGUARD GROUP INC | 102909 | 4.04M | 132.19M | Dec 31, 2025 |
| 6 | FAIRMOUNT FUNDS MANAGEMENT LLC | 1802528 | 4.02M | 202.67M | Mar 31, 2026 |
| 7 | PARADIGM BIOCAPITAL ADVISORS LP | 1855655 | 3.84M | 340.98M | Jun 30, 2026 |
| 8 | VANGUARD CAPITAL MANAGEMENT LLC | 2100119 | 3.45M | 306.17M | Jun 30, 2026 |
| 9 | STATE STREET CORP | 93751 | 3.06M | 271.44M | Jun 30, 2026 |
| 10 | VENROCK ADVISER, LLC | 1615982 | 2.99M | 265.05M | Jun 30, 2026 |
| 11 | PRICE T ROWE ASSOCIATES INC /MD/ | 80255 | 2.96M | 262.87K | Jun 30, 2026 |
| 12 | DRIEHAUS CAPITAL MANAGEMENT LLC | 938206 | 2.80M | 248.51M | Jun 30, 2026 |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 1214717 | 2.56M | 239.26M | Jun 30, 2026 |
| 14 | BLACKROCK FINANCE, INC. | 1364742 | 2.40M | 56.50M | Jun 30, 2024 |
| 15 | VANGUARD PORTFOLIO MANAGEMENT LLC | 2100121 | 2.33M | 206.87M | Jun 30, 2026 |
| 16 | CAPITAL WORLD INVESTORS | 1422849 | 2.32M | 205.57M | Jun 30, 2026 |
| 17 | JUPITER TOPCO LLC | 2146052 | 2.21M | 195.88M | Jun 30, 2026 |
| 18 | TCG CROSSOVER MANAGEMENT, LLC | 1839948 | 1.90M | 168.73M | Jun 30, 2026 |
| 19 | TANG CAPITAL MANAGEMENT LLC | 1232621 | 1.89M | 167.99M | Jun 30, 2026 |
| 20 | BANK OF AMERICA CORP /DE/ | 70858 | 1.78M | 157.84M | Jun 30, 2026 |
Data sourced from SEC Form 13F institutional holdings reports. Positions reflect the most recent filing per institution.