SPHERA FUNDS MANAGEMENT LTD.

PrivateCIK: 1496201
Location

TEL AVIV, L3

95
Positions
$629.68M
Total AUM (reported)
36.38M
Total Shares

Allocation by class

TOTAL AUM$629.68M95 positions
COM$388.07M61.6%
COM NEW$50.67M8.0%
SPONSORED ADS$36.69M5.8%
SHS NEW$29.97M4.8%
SPONSORED ADR$27.82M4.4%
STATE STREET SPD$25.55M4.1%
ORD$20.37M3.2%

Portfolio Concentration

Top 315.3%4–1021.8%11–2522.0%Rest40.9%TOP 1037.1%0%100%
Top 3$96.12M15.3%
4–10$137.49M21.8%
11–25$138.38M22.0%
Rest$257.70M40.9%

Top 3 weight

15.3%

Top 10 weight

37.1%

Voting Authority Distribution

Total shares with voting rights: 35.97M

Sole

Full voting authority

35.97M

shares

% of voting shares100.0%
Shared

Joint voting authority

0.00

shares

% of voting shares0.0%
None

No voting authority

0.00

shares

% of voting shares0.0%

Investment Discretion (by position count)

Sole0
Shared0
Other95
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings95
Rows:

MINERALYS THERAPEUTICS INC

DFND
COM
Shares1.34M
TypeSH
Market value$36.30M
5.76%
Sole
1.34M
Shared
0.00
None
0.00

TEVA PHARMACEUTICAL INDS LTD

DFND
SPONSORED ADS
Shares1.14M
TypeSH
Market value$34.25M
5.44%
Sole
1.14M
Shared
0.00
None
0.00

TOWER SEMICONDUCTOR LTD

DFND
SHS NEW
Shares145.74K
TypeSH
Market value$25.57M
4.06%
Sole
145.74K
Shared
0.00
None
0.00

SPDR SERIES TRUST

DFND
STATE STREET SPD
Shares200K
TypeSH
Market value$25.55M
4.06%
Sole
200K
Shared
0.00
None
0.00

NOVA LTD

DFND
COM
Shares53.37K
TypeSH
Market value$23.18M
3.68%
Sole
53.37K
Shared
0.00
None
0.00

CYTOKINETICS INC

DFND
COM NEW
Shares299.12K
TypeSH
Market value$19.71M
3.13%
Sole
39.82K
Shared
0.00
None
0.00

BRIDGEBIO PHARMA INC

DFND
COM
Shares245.25K
TypeSH
Market value$18.21M
2.89%
Sole
245.25K
Shared
0.00
None
0.00

BIOGEN INC

DFND
COM
Shares92.53K
TypeSH
Market value$16.96M
2.69%
Sole
92.53K
Shared
0.00
None
0.00

ULTRAGENYX PHARMACEUTICAL IN

DFND
COM
Shares809.33K
TypeSH
Market value$16.96M
2.69%
Sole
809.33K
Shared
0.00
None
0.00

SYNDAX PHARMACEUTICALS INC

DFND
COM
Shares724.56K
TypeSH
Market value$16.93M
2.69%
Sole
724.56K
Shared
0.00
None
0.00

COGENT BIOSCIENCES INC

DFND
COM
Shares416.34K
TypeSH
Market value$16.02M
2.54%
Sole
416.34K
Shared
0.00
None
0.00

SANOFI SA

DFND
SPONSORED ADR
Shares269.51K
TypeSH
Market value$12.99M
2.06%
Sole
269.51K
Shared
0.00
None
0.00

ASTRAZENECA PLC

DFND
ORD
Shares62.53K
TypeSH
Market value$12.33M
1.96%
Sole
62.53K
Shared
0.00
None
0.00

AMICUS THERAPEUTIC

DFND
COM
Shares603.38K
TypeSH
Market value$8.72M
1.39%
Sole
603.38K
Shared
0.00
None
0.00

CELLEBRITE DI LTD

DFND
ORDINARY SHARES
Shares631.52K
TypeSH
Market value$8.70M
1.38%
Sole
631.52K
Shared
0.00
None
0.00

APELLIS PHARMACEUTICALS INC

DFND
COM
Shares214.91K
TypeSH
Market value$8.65M
1.37%
Sole
214.91K
Shared
0.00
None
0.00

PALO ALTO NETWORKS INC

DFND
COM
Shares52.80K
TypeSH
Market value$8.46M
1.34%
Sole
52.80K
Shared
0.00
None
0.00

ELI LILLY & CO

DFND
COM
Shares9.04K
TypeSH
Market value$8.31M
1.32%
Sole
9.04K
Shared
0.00
None
0.00

BIOCRYST PHARMACEUTICALS INC

DFND
COM
Shares866.46K
TypeSH
Market value$8.25M
1.31%
Sole
866.46K
Shared
0.00
None
0.00

CAMTEK LTD

DFND
ORD
Shares53.02K
TypeSH
Market value$8.04M
1.28%
Sole
53.02K
Shared
0.00
None
0.00

BIOMARIN PHARMACEUTICAL INC

DFND
COM
Shares139.90K
TypeSH
Market value$7.90M
1.26%
Sole
139.90K
Shared
0.00
None
0.00

CELLDEX THERAPEUTICS INC NEW

DFND
COM NEW
Shares243.57K
TypeSH
Market value$7.73M
1.23%
Sole
243.57K
Shared
0.00
None
0.00

ORMAT TECHNOLOGIES INC

DFND
COM
Shares68.25K
TypeSH
Market value$7.64M
1.21%
Sole
68.25K
Shared
0.00
None
0.00

XENON PHARMACEUTICALS INC

DFND
COM
Shares127K
TypeSH
Market value$7.39M
1.17%
Sole
127K
Shared
0.00
None
0.00

SOLENO THERAPEUTICS INC

DFND
COM
Shares216.28K
TypeSH
Market value$7.24M
1.15%
Sole
216.28K
Shared
0.00
None
0.00
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