Filed: 5/15/2026ACC: 0001496201-26-000003
📋 What this filing means
SPHERA FUNDS MANAGEMENT LTD. filed this quarterly 13F‑HR report disclosing 95 equity positions with a total reported market value of $629.68M. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
95
Positions
$629.68M
Total AUM (reported)
36.38M
Total Shares
Allocation by class
COM$388.07M61.6%
COM NEW$50.67M8.0%
SPONSORED ADS$36.69M5.8%
SHS NEW$29.97M4.8%
SPONSORED ADR$27.82M4.4%
STATE STREET SPD$25.55M4.1%
ORD$20.37M3.2%
Portfolio Concentration
Top 3$96.12M15.3%
4–10$137.49M21.8%
11–25$138.38M22.0%
Rest$257.70M40.9%
Top 3 weight
15.3%
Top 10 weight
37.1%
Voting Authority Distribution
Total shares with voting rights: 35.97M
Sole
Full voting authority
35.97M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole0
Shared0
Other95
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings95
Rows:
MINERALYS THERAPEUTICS INC
DFNDShares1.34M
TypeSH
Market value$36.30M
5.76%
Sole
1.34M
Shared
0.00
None
0.00
TEVA PHARMACEUTICAL INDS LTD
DFNDShares1.14M
TypeSH
Market value$34.25M
5.44%
Sole
1.14M
Shared
0.00
None
0.00
TOWER SEMICONDUCTOR LTD
DFNDShares145.74K
TypeSH
Market value$25.57M
4.06%
Sole
145.74K
Shared
0.00
None
0.00
SPDR SERIES TRUST
DFNDShares200K
TypeSH
Market value$25.55M
4.06%
Sole
200K
Shared
0.00
None
0.00
NOVA LTD
DFNDShares53.37K
TypeSH
Market value$23.18M
3.68%
Sole
53.37K
Shared
0.00
None
0.00
CYTOKINETICS INC
DFNDShares299.12K
TypeSH
Market value$19.71M
3.13%
Sole
39.82K
Shared
0.00
None
0.00
BRIDGEBIO PHARMA INC
DFNDShares245.25K
TypeSH
Market value$18.21M
2.89%
Sole
245.25K
Shared
0.00
None
0.00
BIOGEN INC
DFNDShares92.53K
TypeSH
Market value$16.96M
2.69%
Sole
92.53K
Shared
0.00
None
0.00
ULTRAGENYX PHARMACEUTICAL IN
DFNDShares809.33K
TypeSH
Market value$16.96M
2.69%
Sole
809.33K
Shared
0.00
None
0.00
SYNDAX PHARMACEUTICALS INC
DFNDShares724.56K
TypeSH
Market value$16.93M
2.69%
Sole
724.56K
Shared
0.00
None
0.00
COGENT BIOSCIENCES INC
DFNDShares416.34K
TypeSH
Market value$16.02M
2.54%
Sole
416.34K
Shared
0.00
None
0.00
SANOFI SA
DFNDShares269.51K
TypeSH
Market value$12.99M
2.06%
Sole
269.51K
Shared
0.00
None
0.00
ASTRAZENECA PLC
DFNDShares62.53K
TypeSH
Market value$12.33M
1.96%
Sole
62.53K
Shared
0.00
None
0.00
AMICUS THERAPEUTIC
DFNDShares603.38K
TypeSH
Market value$8.72M
1.39%
Sole
603.38K
Shared
0.00
None
0.00
CELLEBRITE DI LTD
DFNDShares631.52K
TypeSH
Market value$8.70M
1.38%
Sole
631.52K
Shared
0.00
None
0.00
APELLIS PHARMACEUTICALS INC
DFNDShares214.91K
TypeSH
Market value$8.65M
1.37%
Sole
214.91K
Shared
0.00
None
0.00
PALO ALTO NETWORKS INC
DFNDShares52.80K
TypeSH
Market value$8.46M
1.34%
Sole
52.80K
Shared
0.00
None
0.00
ELI LILLY & CO
DFNDShares9.04K
TypeSH
Market value$8.31M
1.32%
Sole
9.04K
Shared
0.00
None
0.00
BIOCRYST PHARMACEUTICALS INC
DFNDShares866.46K
TypeSH
Market value$8.25M
1.31%
Sole
866.46K
Shared
0.00
None
0.00
CAMTEK LTD
DFNDShares53.02K
TypeSH
Market value$8.04M
1.28%
Sole
53.02K
Shared
0.00
None
0.00
BIOMARIN PHARMACEUTICAL INC
DFNDShares139.90K
TypeSH
Market value$7.90M
1.26%
Sole
139.90K
Shared
0.00
None
0.00
CELLDEX THERAPEUTICS INC NEW
DFNDShares243.57K
TypeSH
Market value$7.73M
1.23%
Sole
243.57K
Shared
0.00
None
0.00
ORMAT TECHNOLOGIES INC
DFNDShares68.25K
TypeSH
Market value$7.64M
1.21%
Sole
68.25K
Shared
0.00
None
0.00
XENON PHARMACEUTICALS INC
DFNDShares127K
TypeSH
Market value$7.39M
1.17%
Sole
127K
Shared
0.00
None
0.00
SOLENO THERAPEUTICS INC
DFNDShares216.28K
TypeSH
Market value$7.24M
1.15%
Sole
216.28K
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
MINERALYS THERAPEUTICS INCDFND | COM | 1.34M | SH | $36.30M 5.76% | 1.34M | 0.00 | 0.00 |
TEVA PHARMACEUTICAL INDS LTDDFND | SPONSORED ADS | 1.14M | SH | $34.25M 5.44% | 1.14M | 0.00 | 0.00 |
TOWER SEMICONDUCTOR LTDDFND | SHS NEW | 145.74K | SH | $25.57M 4.06% | 145.74K | 0.00 | 0.00 |
SPDR SERIES TRUSTDFND | STATE STREET SPD | 200K | SH | $25.55M 4.06% | 200K | 0.00 | 0.00 |
NOVA LTDDFND | COM | 53.37K | SH | $23.18M 3.68% | 53.37K | 0.00 | 0.00 |
CYTOKINETICS INCDFND | COM NEW | 299.12K | SH | $19.71M 3.13% | 39.82K | 0.00 | 0.00 |
BRIDGEBIO PHARMA INCDFND | COM | 245.25K | SH | $18.21M 2.89% | 245.25K | 0.00 | 0.00 |
BIOGEN INCDFND | COM | 92.53K | SH | $16.96M 2.69% | 92.53K | 0.00 | 0.00 |
ULTRAGENYX PHARMACEUTICAL INDFND | COM | 809.33K | SH | $16.96M 2.69% | 809.33K | 0.00 | 0.00 |
SYNDAX PHARMACEUTICALS INCDFND | COM | 724.56K | SH | $16.93M 2.69% | 724.56K | 0.00 | 0.00 |
COGENT BIOSCIENCES INCDFND | COM | 416.34K | SH | $16.02M 2.54% | 416.34K | 0.00 | 0.00 |
SANOFI SADFND | SPONSORED ADR | 269.51K | SH | $12.99M 2.06% | 269.51K | 0.00 | 0.00 |
ASTRAZENECA PLCDFND | ORD | 62.53K | SH | $12.33M 1.96% | 62.53K | 0.00 | 0.00 |
AMICUS THERAPEUTICDFND | COM | 603.38K | SH | $8.72M 1.39% | 603.38K | 0.00 | 0.00 |
CELLEBRITE DI LTDDFND | ORDINARY SHARES | 631.52K | SH | $8.70M 1.38% | 631.52K | 0.00 | 0.00 |
APELLIS PHARMACEUTICALS INCDFND | COM | 214.91K | SH | $8.65M 1.37% | 214.91K | 0.00 | 0.00 |
PALO ALTO NETWORKS INCDFND | COM | 52.80K | SH | $8.46M 1.34% | 52.80K | 0.00 | 0.00 |
ELI LILLY & CODFND | COM | 9.04K | SH | $8.31M 1.32% | 9.04K | 0.00 | 0.00 |
BIOCRYST PHARMACEUTICALS INCDFND | COM | 866.46K | SH | $8.25M 1.31% | 866.46K | 0.00 | 0.00 |
CAMTEK LTDDFND | ORD | 53.02K | SH | $8.04M 1.28% | 53.02K | 0.00 | 0.00 |
BIOMARIN PHARMACEUTICAL INCDFND | COM | 139.90K | SH | $7.90M 1.26% | 139.90K | 0.00 | 0.00 |
CELLDEX THERAPEUTICS INC NEWDFND | COM NEW | 243.57K | SH | $7.73M 1.23% | 243.57K | 0.00 | 0.00 |
ORMAT TECHNOLOGIES INCDFND | COM | 68.25K | SH | $7.64M 1.21% | 68.25K | 0.00 | 0.00 |
XENON PHARMACEUTICALS INCDFND | COM | 127K | SH | $7.39M 1.17% | 127K | 0.00 | 0.00 |
SOLENO THERAPEUTICS INCDFND | COM | 216.28K | SH | $7.24M 1.15% | 216.28K | 0.00 | 0.00 |
Page 1 of 4