SOUTH SAN FRANCISCO, CA
SEPTERNA, INC.SEPN— Latest position per institution from SEC 13F filings
15
Institutional holders
44.81M
Total shares held
1.46B
Estimated value
2.24M
Avg. position size
RA CAPITAL MANAGEMENT, L.P.
CIK 1346824
Shares
7M
Value
234.29M
Filed
Jun 30, 2026
TRV GP V, LLC
CIK 1990717
Shares
6.22M
Value
208.16M
Filed
Jun 30, 2026
DRIEHAUS CAPITAL MANAGEMENT LLC
CIK 938206
Shares
4.43M
Value
148.46M
Filed
Jun 30, 2026
TRV GP VI, LLC
CIK 1990716
Shares
4.21M
Value
141.05M
Filed
Jun 30, 2026
SAMSARA BIOCAPITAL, LLC
CIK 1744967
Shares
3.15M
Value
105.46M
Filed
Jun 30, 2026
GOLDMAN SACHS GROUP INC
CIK 886982
Shares
3.06M
Value
102.57M
Filed
Jun 30, 2026
BLACKROCK, INC.
CIK 2012383
Shares
1.93M
Value
64.71M
Filed
Jun 30, 2026
SIREN, L.L.C.
CIK 2005245
Shares
1.90M
Value
63.63M
Filed
Jun 30, 2026
VANGUARD GROUP INC
CIK 102909
Shares
1.51M
Value
42.05M
Filed
Dec 31, 2025
BVF INC/IL
CIK 1056807
Shares
1.35M
Value
32.52M
Filed
Mar 31, 2026
AVORO CAPITAL ADVISORS LLC
CIK 1633313
Shares
1.34M
Value
44.79M
Filed
Jun 30, 2026
JUPITER TOPCO LLC
CIK 2146052
Shares
1.31M
Value
43.72M
Filed
Jun 30, 2026
VANGUARD CAPITAL MANAGEMENT LLC
CIK 2100119
Shares
1.22M
Value
40.91M
Filed
Jun 30, 2026
PRIMECAP MANAGEMENT CO/CA/
CIK 763212
Shares
1.17M
Value
39.10M
Filed
Jun 30, 2026
FIRST LIGHT ASSET MANAGEMENT, LLC
CIK 1600004
Shares
963.26K
Value
32.26M
Filed
Jun 30, 2026
ADAR1 CAPITAL MANAGEMENT, LLC
CIK 1940272
Shares
940.75K
Value
31.51M
Filed
Jun 30, 2026
JANUS HENDERSON GROUP LTD.
CIK 1274173
Shares
890.75K
Value
21.33M
Filed
Mar 31, 2026
DEERFIELD MANAGEMENT COMPANY, L.P.
CIK 1009258
Shares
861.81K
Value
19.74M
Filed
Dec 31, 2024
GEODE CAPITAL MANAGEMENT, LLC
CIK 1214717
Shares
679.16K
Value
22.75M
Filed
Jun 30, 2026
CAPTION MANAGEMENT, LLC
CIK 1706766
Shares
678.01K
Value
22.71M
Filed
Jun 30, 2026
| # | Institution | CIK | Shares | Est. Value | Period |
|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 1346824 | 7M | 234.29M | Jun 30, 2026 |
| 2 | TRV GP V, LLC | 1990717 | 6.22M | 208.16M | Jun 30, 2026 |
| 3 | DRIEHAUS CAPITAL MANAGEMENT LLC | 938206 | 4.43M | 148.46M | Jun 30, 2026 |
| 4 | TRV GP VI, LLC | 1990716 | 4.21M | 141.05M | Jun 30, 2026 |
| 5 | SAMSARA BIOCAPITAL, LLC | 1744967 | 3.15M | 105.46M | Jun 30, 2026 |
| 6 | GOLDMAN SACHS GROUP INC | 886982 | 3.06M | 102.57M | Jun 30, 2026 |
| 7 | BLACKROCK, INC. | 2012383 | 1.93M | 64.71M | Jun 30, 2026 |
| 8 | SIREN, L.L.C. | 2005245 | 1.90M | 63.63M | Jun 30, 2026 |
| 9 | VANGUARD GROUP INC | 102909 | 1.51M | 42.05M | Dec 31, 2025 |
| 10 | BVF INC/IL | 1056807 | 1.35M | 32.52M | Mar 31, 2026 |
| 11 | AVORO CAPITAL ADVISORS LLC | 1633313 | 1.34M | 44.79M | Jun 30, 2026 |
| 12 | JUPITER TOPCO LLC | 2146052 | 1.31M | 43.72M | Jun 30, 2026 |
| 13 | VANGUARD CAPITAL MANAGEMENT LLC | 2100119 | 1.22M | 40.91M | Jun 30, 2026 |
| 14 | PRIMECAP MANAGEMENT CO/CA/ | 763212 | 1.17M | 39.10M | Jun 30, 2026 |
| 15 | FIRST LIGHT ASSET MANAGEMENT, LLC | 1600004 | 963.26K | 32.26M | Jun 30, 2026 |
| 16 | ADAR1 CAPITAL MANAGEMENT, LLC | 1940272 | 940.75K | 31.51M | Jun 30, 2026 |
| 17 | JANUS HENDERSON GROUP LTD. | 1274173 | 890.75K | 21.33M | Mar 31, 2026 |
| 18 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1009258 | 861.81K | 19.74M | Dec 31, 2024 |
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 1214717 | 679.16K | 22.75M | Jun 30, 2026 |
| 20 | CAPTION MANAGEMENT, LLC | 1706766 | 678.01K | 22.71M | Jun 30, 2026 |
Data sourced from SEC Form 13F institutional holdings reports. Positions reflect the most recent filing per institution.