ORCHESTRA BIOMED HOLDINGS, INC.

PublicCIK: 1814114
OBIONASDAQ
Location

NEW HOPE, PA

13F Filings

Institutional Holders

ORCHESTRA BIOMED HOLDINGS, INC.OBIO— Latest position per institution from SEC 13F filings

15

Institutional holders

30.91M

Total shares held

136.82M

Estimated value

1.55M

Avg. position size

1

RTW INVESTMENTS, LP

CIK 1493215

Shares

9.56M

Value

41.23M

Filed

Jun 30, 2026

2

PERCEPTIVE ADVISORS LLC

CIK 1224962

Shares

5.04M

Value

21.74M

Filed

Jun 30, 2026

3

BLACKROCK, INC.

CIK 2012383

Shares

2.51M

Value

10.83M

Filed

Jun 30, 2026

4

VANGUARD CAPITAL MANAGEMENT LLC

CIK 2100119

Shares

2.02M

Value

8.73M

Filed

Jun 30, 2026

5

BLACKROCK FINANCE, INC.

CIK 1364742

Shares

1.86M

Value

15.20M

Filed

Jun 30, 2024

6

VANGUARD GROUP INC

CIK 102909

Shares

1.60M

Value

6.66M

Filed

Dec 31, 2025

7

GEODE CAPITAL MANAGEMENT, LLC

CIK 1214717

Shares

1.01M

Value

4.35M

Filed

Jun 30, 2026

8

PATHSTONE HOLDINGS, LLC

CIK 2011612

Shares

1.01M

Value

2.49M

Filed

Sep 30, 2025

9

ALYESKA INVESTMENT GROUP, L.P.

CIK 1453072

Shares

1M

Value

4.32M

Filed

Jun 30, 2026

10

PROPEL BIO MANAGEMENT, LLC

CIK 1969764

Shares

896.70K

Value

3.87M

Filed

Jun 30, 2026

11

MILLENNIUM MANAGEMENT LLC

CIK 1273087

Shares

702.54K

Value

2.99M

Filed

Mar 31, 2026

12

UBS AM, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS LLC

CIK 861177

Shares

642.15K

Value

2.77M

Filed

Jun 30, 2026

13

STATE STREET CORP

CIK 93751

Shares

516.05K

Value

2.23M

Filed

Jun 30, 2026

14

KNOLL CAPITAL MANAGEMENT, LLC

CIK 1325083

Shares

455.13K

Value

421.16K

Filed

Sep 30, 2025

15

RICE HALL JAMES & ASSOCIATES, LLC

CIK 1230765

Shares

424K

Value

1.83M

Filed

Jun 30, 2026

16

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

CIK 884546

Shares

349.54K

Value

1.51M

Filed

Jun 30, 2026

17

SIXTH STREET PARTNERS MANAGEMENT COMPANY, L.P.

CIK 1812095

Shares

349.54K

Value

1.51M

Filed

Jun 30, 2026

18

NORTHERN TRUST CORP

CIK 73124

Shares

343.64K

Value

1.48M

Filed

Jun 30, 2026

19

UBS GROUP AG

CIK 1610520

Shares

325.77K

Value

1.41M

Filed

Jun 30, 2026

20

VANGUARD FIDUCIARY TRUST CO

CIK 933478

Shares

292.25K

Value

1.26M

Filed

Jun 30, 2026

Data sourced from SEC Form 13F institutional holdings reports. Positions reflect the most recent filing per institution.