NEW HOPE, PA
ORCHESTRA BIOMED HOLDINGS, INC.OBIO— Latest position per institution from SEC 13F filings
15
Institutional holders
26.42M
Total shares held
114.72M
Estimated value
1.32M
Avg. position size
RTW INVESTMENTS, LP
CIK 1493215
Shares
8.31M
Value
35.30M
Filed
Mar 31, 2026
PERCEPTIVE ADVISORS LLC
CIK 1224962
Shares
5.04M
Value
21.41M
Filed
Mar 31, 2026
VANGUARD CAPITAL MANAGEMENT LLC
CIK 2100119
Shares
2.20M
Value
9.37M
Filed
Mar 31, 2026
BLACKROCK FINANCE, INC.
CIK 1364742
Shares
1.86M
Value
15.20M
Filed
Jun 30, 2024
VANGUARD GROUP INC
CIK 102909
Shares
1.60M
Value
6.66M
Filed
Dec 31, 2025
PATHSTONE HOLDINGS, LLC
CIK 2011612
Shares
1.01M
Value
2.49M
Filed
Sep 30, 2025
ALYESKA INVESTMENT GROUP, L.P.
CIK 1453072
Shares
1M
Value
4.25M
Filed
Mar 31, 2026
PROPEL BIO MANAGEMENT, LLC
CIK 1969764
Shares
896.70K
Value
3.83M
Filed
Mar 31, 2026
MILLENNIUM MANAGEMENT LLC
CIK 1273087
Shares
702.54K
Value
2.99M
Filed
Mar 31, 2026
BLACKROCK, INC.
CIK 2012383
Shares
635.71K
Value
2.70M
Filed
Mar 31, 2026
GEODE CAPITAL MANAGEMENT, LLC
CIK 1214717
Shares
485.49K
Value
2.06M
Filed
Mar 31, 2026
KNOLL CAPITAL MANAGEMENT, LLC
CIK 1325083
Shares
455.13K
Value
421.16K
Filed
Sep 30, 2025
AFFINITY ASSET ADVISORS, LLC
CIK 1773195
Shares
402.55K
Value
1.71M
Filed
Mar 31, 2026
PRICE T ROWE ASSOCIATES INC /MD/
CIK 80255
Shares
364.64K
Value
1.51K
Filed
Dec 31, 2025
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
CIK 884546
Shares
265.50K
Value
1.13M
Filed
Mar 31, 2026
KNOTT DAVID M JR
CIK 1892770
Shares
253.65K
Value
1.08M
Filed
Mar 31, 2026
BOXER CAPITAL, LLC
CIK 1465837
Shares
238.19K
Value
1.22M
Filed
Sep 30, 2024
BOXER CAPITAL MANAGEMENT, LLC
CIK 2018299
Shares
238.19K
Value
952.77K
Filed
Dec 31, 2024
VANGUARD FIDUCIARY TRUST CO
CIK 933478
Shares
235.21K
Value
999.66K
Filed
Mar 31, 2026
SIMPLIFY ASSET MANAGEMENT INC.
CIK 1846368
Shares
219.39K
Value
932.39K
Filed
Mar 31, 2026
| # | Institution | CIK | Shares | Est. Value | Period |
|---|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LP | 1493215 | 8.31M | 35.30M | Mar 31, 2026 |
| 2 | PERCEPTIVE ADVISORS LLC | 1224962 | 5.04M | 21.41M | Mar 31, 2026 |
| 3 | VANGUARD CAPITAL MANAGEMENT LLC | 2100119 | 2.20M | 9.37M | Mar 31, 2026 |
| 4 | BLACKROCK FINANCE, INC. | 1364742 | 1.86M | 15.20M | Jun 30, 2024 |
| 5 | VANGUARD GROUP INC | 102909 | 1.60M | 6.66M | Dec 31, 2025 |
| 6 | PATHSTONE HOLDINGS, LLC | 2011612 | 1.01M | 2.49M | Sep 30, 2025 |
| 7 | ALYESKA INVESTMENT GROUP, L.P. | 1453072 | 1M | 4.25M | Mar 31, 2026 |
| 8 | PROPEL BIO MANAGEMENT, LLC | 1969764 | 896.70K | 3.83M | Mar 31, 2026 |
| 9 | MILLENNIUM MANAGEMENT LLC | 1273087 | 702.54K | 2.99M | Mar 31, 2026 |
| 10 | BLACKROCK, INC. | 2012383 | 635.71K | 2.70M | Mar 31, 2026 |
| 11 | GEODE CAPITAL MANAGEMENT, LLC | 1214717 | 485.49K | 2.06M | Mar 31, 2026 |
| 12 | KNOLL CAPITAL MANAGEMENT, LLC | 1325083 | 455.13K | 421.16K | Sep 30, 2025 |
| 13 | AFFINITY ASSET ADVISORS, LLC | 1773195 | 402.55K | 1.71M | Mar 31, 2026 |
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 80255 | 364.64K | 1.51K | Dec 31, 2025 |
| 15 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 884546 | 265.50K | 1.13M | Mar 31, 2026 |
| 16 | KNOTT DAVID M JR | 1892770 | 253.65K | 1.08M | Mar 31, 2026 |
| 17 | BOXER CAPITAL, LLC | 1465837 | 238.19K | 1.22M | Sep 30, 2024 |
| 18 | BOXER CAPITAL MANAGEMENT, LLC | 2018299 | 238.19K | 952.77K | Dec 31, 2024 |
| 19 | VANGUARD FIDUCIARY TRUST CO | 933478 | 235.21K | 999.66K | Mar 31, 2026 |
| 20 | SIMPLIFY ASSET MANAGEMENT INC. | 1846368 | 219.39K | 932.39K | Mar 31, 2026 |
Data sourced from SEC Form 13F institutional holdings reports. Positions reflect the most recent filing per institution.