NEWTON, MA
KARYOPHARM THERAPEUTICS INC.KPTI— Latest position per institution from SEC 13F filings
15
Institutional holders
20.88M
Total shares held
111.65M
Estimated value
1.04M
Avg. position size
IKARIAN CAPITAL, LLC
CIK 1778253
Shares
2.57M
Value
14.33M
Filed
Mar 31, 2026
COMMODORE CAPITAL LP
CIK 1831942
Shares
1.95M
Value
10.86M
Filed
Mar 31, 2026
RA CAPITAL MANAGEMENT, L.P.
CIK 1346824
Shares
1.92M
Value
10.68M
Filed
Mar 31, 2026
ADAGE CAPITAL PARTNERS GP, L.L.C.
CIK 1165408
Shares
1.81M
Value
10.06M
Filed
Mar 31, 2026
T. ROWE PRICE INVESTMENT MANAGEMENT, INC.
CIK 1897612
Shares
1.54M
Value
8.59K
Filed
Mar 31, 2026
SUSQUEHANNA INTERNATIONAL GROUP, LLP
CIK 1446194
Shares
1.32M
Value
7.32M
Filed
Mar 31, 2026
CAPTION MANAGEMENT, LLC
CIK 1706766
Shares
1.18M
Value
6.58M
Filed
Mar 31, 2026
GOLDMAN SACHS GROUP INC
CIK 886982
Shares
947.58K
Value
5.28M
Filed
Mar 31, 2026
OPALEYE MANAGEMENT INC.
CIK 1595855
Shares
930K
Value
6.84M
Filed
Dec 31, 2025
CATALIO CAPITAL MANAGEMENT, LP
CIK 1958125
Shares
897.71K
Value
5M
Filed
Mar 31, 2026
BOOTHBAY FUND MANAGEMENT, LLC
CIK 1549230
Shares
750.41K
Value
4.18M
Filed
Mar 31, 2026
SQUADRON CAPITAL MANAGEMENT LLC
CIK 2050709
Shares
750K
Value
4.18M
Filed
Mar 31, 2026
VANGUARD CAPITAL MANAGEMENT LLC
CIK 2100119
Shares
739.75K
Value
4.12M
Filed
Mar 31, 2026
JANE STREET GROUP, LLC
CIK 1595888
Shares
593.70K
Value
3.31M
Filed
Mar 31, 2026
VANGUARD GROUP INC
CIK 102909
Shares
559.62K
Value
4.12M
Filed
Dec 31, 2025
MILLENNIUM MANAGEMENT LLC
CIK 1273087
Shares
511.57K
Value
2.85M
Filed
Mar 31, 2026
CITADEL ADVISORS LLC
CIK 1423053
Shares
507.50K
Value
2.83M
Filed
Mar 31, 2026
AFFINITY ASSET ADVISORS, LLC
CIK 1773195
Shares
500K
Value
2.79M
Filed
Mar 31, 2026
AVIDITY PARTNERS MANAGEMENT LP
CIK 1791827
Shares
463.74K
Value
3.85M
Filed
Mar 31, 2026
SOLEUS CAPITAL MANAGEMENT, L.P.
CIK 1802630
Shares
440K
Value
2.45M
Filed
Mar 31, 2026
| # | Institution | CIK | Shares | Est. Value | Period |
|---|---|---|---|---|---|
| 1 | IKARIAN CAPITAL, LLC | 1778253 | 2.57M | 14.33M | Mar 31, 2026 |
| 2 | COMMODORE CAPITAL LP | 1831942 | 1.95M | 10.86M | Mar 31, 2026 |
| 3 | RA CAPITAL MANAGEMENT, L.P. | 1346824 | 1.92M | 10.68M | Mar 31, 2026 |
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1165408 | 1.81M | 10.06M | Mar 31, 2026 |
| 5 | T. ROWE PRICE INVESTMENT MANAGEMENT, INC. | 1897612 | 1.54M | 8.59K | Mar 31, 2026 |
| 6 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1446194 | 1.32M | 7.32M | Mar 31, 2026 |
| 7 | CAPTION MANAGEMENT, LLC | 1706766 | 1.18M | 6.58M | Mar 31, 2026 |
| 8 | GOLDMAN SACHS GROUP INC | 886982 | 947.58K | 5.28M | Mar 31, 2026 |
| 9 | OPALEYE MANAGEMENT INC. | 1595855 | 930K | 6.84M | Dec 31, 2025 |
| 10 | CATALIO CAPITAL MANAGEMENT, LP | 1958125 | 897.71K | 5M | Mar 31, 2026 |
| 11 | BOOTHBAY FUND MANAGEMENT, LLC | 1549230 | 750.41K | 4.18M | Mar 31, 2026 |
| 12 | SQUADRON CAPITAL MANAGEMENT LLC | 2050709 | 750K | 4.18M | Mar 31, 2026 |
| 13 | VANGUARD CAPITAL MANAGEMENT LLC | 2100119 | 739.75K | 4.12M | Mar 31, 2026 |
| 14 | JANE STREET GROUP, LLC | 1595888 | 593.70K | 3.31M | Mar 31, 2026 |
| 15 | VANGUARD GROUP INC | 102909 | 559.62K | 4.12M | Dec 31, 2025 |
| 16 | MILLENNIUM MANAGEMENT LLC | 1273087 | 511.57K | 2.85M | Mar 31, 2026 |
| 17 | CITADEL ADVISORS LLC | 1423053 | 507.50K | 2.83M | Mar 31, 2026 |
| 18 | AFFINITY ASSET ADVISORS, LLC | 1773195 | 500K | 2.79M | Mar 31, 2026 |
| 19 | AVIDITY PARTNERS MANAGEMENT LP | 1791827 | 463.74K | 3.85M | Mar 31, 2026 |
| 20 | SOLEUS CAPITAL MANAGEMENT, L.P. | 1802630 | 440K | 2.45M | Mar 31, 2026 |
Data sourced from SEC Form 13F institutional holdings reports. Positions reflect the most recent filing per institution.