CARLSBAD, CA
IONIS PHARMACEUTICALS INCIONS— Latest position per institution from SEC 13F filings
15
Institutional holders
154.48M
Total shares held
10.62B
Estimated value
7.72M
Avg. position size
FMR LLC
CIK 315066
Shares
24.63M
Value
1.95B
Filed
Jun 30, 2026
CAPITAL WORLD INVESTORS
CIK 1422849
Shares
21.67M
Value
1.72B
Filed
Jun 30, 2026
VANGUARD GROUP INC
CIK 102909
Shares
16.44M
Value
1.30B
Filed
Dec 31, 2025
BLACKROCK, INC.
CIK 2012383
Shares
10.70M
Value
848.77M
Filed
Jun 30, 2026
BLACKROCK FINANCE, INC.
CIK 1364742
Shares
10.32M
Value
491.90M
Filed
Jun 30, 2024
VANGUARD PORTFOLIO MANAGEMENT LLC
CIK 2100121
Shares
7.86M
Value
623.18M
Filed
Jun 30, 2026
WELLINGTON MANAGEMENT GROUP LLP
CIK 902219
Shares
7.65M
Value
606.68M
Filed
Jun 30, 2026
VANGUARD CAPITAL MANAGEMENT LLC
CIK 2100119
Shares
7.21M
Value
571.80M
Filed
Jun 30, 2026
LOMBARD ODIER ASSET MANAGEMENT (EUROPE) LTD
CIK 1535784
Shares
6.49M
Value
8.96M
Filed
Sep 30, 2025
TWO SIGMA INVESTMENTS, LP
CIK 1179392
Shares
6.25M
Value
495.75M
Filed
Jun 30, 2026
ROYAL BANK OF CANADA
CIK 1000275
Shares
6.18M
Value
490.21M
Filed
Jun 30, 2026
STATE STREET CORP
CIK 93751
Shares
4.33M
Value
343.71M
Filed
Jun 30, 2026
T. ROWE PRICE INVESTMENT MANAGEMENT, INC.
CIK 1897612
Shares
3.96M
Value
313.94K
Filed
Jun 30, 2026
GEODE CAPITAL MANAGEMENT, LLC
CIK 1214717
Shares
3.58M
Value
294.75M
Filed
Jun 30, 2026
PRICE T ROWE ASSOCIATES INC /MD/
CIK 80255
Shares
3.18M
Value
252.50K
Filed
Jun 30, 2026
PICTET ASSET MANAGEMENT SA
CIK 1361570
Shares
3.10M
Value
127.02M
Filed
Jun 30, 2023
TWO SIGMA ADVISERS, LP
CIK 1478735
Shares
3.05M
Value
241.45M
Filed
Dec 31, 2025
JPMORGAN CHASE & CO
CIK 19617
Shares
2.67M
Value
216.20M
Filed
Jun 30, 2026
ARTISAN PARTNERS LIMITED PARTNERSHIP
CIK 1466153
Shares
2.64M
Value
209.33M
Filed
Jun 30, 2026
ORBIMED ADVISORS LLC
CIK 1055951
Shares
2.54M
Value
76.64M
Filed
Mar 31, 2025
| # | Institution | CIK | Shares | Est. Value | Period |
|---|---|---|---|---|---|
| 1 | FMR LLC | 315066 | 24.63M | 1.95B | Jun 30, 2026 |
| 2 | CAPITAL WORLD INVESTORS | 1422849 | 21.67M | 1.72B | Jun 30, 2026 |
| 3 | VANGUARD GROUP INC | 102909 | 16.44M | 1.30B | Dec 31, 2025 |
| 4 | BLACKROCK, INC. | 2012383 | 10.70M | 848.77M | Jun 30, 2026 |
| 5 | BLACKROCK FINANCE, INC. | 1364742 | 10.32M | 491.90M | Jun 30, 2024 |
| 6 | VANGUARD PORTFOLIO MANAGEMENT LLC | 2100121 | 7.86M | 623.18M | Jun 30, 2026 |
| 7 | WELLINGTON MANAGEMENT GROUP LLP | 902219 | 7.65M | 606.68M | Jun 30, 2026 |
| 8 | VANGUARD CAPITAL MANAGEMENT LLC | 2100119 | 7.21M | 571.80M | Jun 30, 2026 |
| 9 | LOMBARD ODIER ASSET MANAGEMENT (EUROPE) LTD | 1535784 | 6.49M | 8.96M | Sep 30, 2025 |
| 10 | TWO SIGMA INVESTMENTS, LP | 1179392 | 6.25M | 495.75M | Jun 30, 2026 |
| 11 | ROYAL BANK OF CANADA | 1000275 | 6.18M | 490.21M | Jun 30, 2026 |
| 12 | STATE STREET CORP | 93751 | 4.33M | 343.71M | Jun 30, 2026 |
| 13 | T. ROWE PRICE INVESTMENT MANAGEMENT, INC. | 1897612 | 3.96M | 313.94K | Jun 30, 2026 |
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 1214717 | 3.58M | 294.75M | Jun 30, 2026 |
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | 80255 | 3.18M | 252.50K | Jun 30, 2026 |
| 16 | PICTET ASSET MANAGEMENT SA | 1361570 | 3.10M | 127.02M | Jun 30, 2023 |
| 17 | TWO SIGMA ADVISERS, LP | 1478735 | 3.05M | 241.45M | Dec 31, 2025 |
| 18 | JPMORGAN CHASE & CO | 19617 | 2.67M | 216.20M | Jun 30, 2026 |
| 19 | ARTISAN PARTNERS LIMITED PARTNERSHIP | 1466153 | 2.64M | 209.33M | Jun 30, 2026 |
| 20 | ORBIMED ADVISORS LLC | 1055951 | 2.54M | 76.64M | Mar 31, 2025 |
Data sourced from SEC Form 13F institutional holdings reports. Positions reflect the most recent filing per institution.