VENROCK HEALTHCARE CAPITAL PARTNERS III, L.P. purchased 42.8% of their position (2.05M shares) of LYCIA THERAPEUTICS, INC. on the open market

Open‑market purchase worth $37.65M — a major conviction buy. The strongest form of insider conviction signal.

P · 6 purchases

VENROCK HEALTHCARE CAPITAL PARTNERS III, L.P.

Filed: 10/27/2026ACC: 0001231919-26-001503

InsiderVENROCK HEALTHCARE CAPITAL PARTNERS III, L.P.CIK 1738048

→

IssuerLYCIA THERAPEUTICS, INC.CIK 1806540

10% Owner

Since Oct 2026

-14.73M

Net shares

Net seller

$37.65M

Total acquired

Open market trades

6B · 0S

Total transactions

6.83M acquired · 21.55M disposed

Non-Derivative Transactions7

Common Stock

Indirect

P · Purchase

+24.56K

Price / share

$25.68

Trade value

$630.70K

% of position

New position

10/23/2026

0.00→24.56K

Common Stock

Indirect

P · Purchase

+28.38K

Price / share

$26.11

Trade value

$740.98K

% of position

115.5%

10/23/2026

24.56K→52.94K

Common Stock

Indirect

C · Conversion

+4.78M

Price / share

—

Trade value

—

% of position

9028.9%

10/26/2026

52.94K→4.83M

Common Stock

Indirect

P · Purchase

+1.94M

Price / share

$18.00

Trade value

$35M

% of position

40.2%

10/26/2026

4.83M→6.78M

Common Stock

Indirect

P · Purchase

+8.26K

Price / share

$26.97

Trade value

$222.80K

% of position

0.1%

10/26/2026

6.78M→6.79M

Common Stock

Indirect

P · Purchase

+8.73K

Price / share

$25.84

Trade value

$225.56K

% of position

0.1%

10/27/2026

6.79M→6.79M

Common Stock

Indirect

P · Purchase

+31.07K

Price / share

$26.84

Trade value

$833.84K

% of position

0.5%

10/27/2026

6.79M→6.83M

Total

Net shares

+6.83M

Net value

$37.65M

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Indirect	10/23/2026	P · Purchase	+24.56K	$25.68	$630.70K	New position	0.00	24.56K
Common Stock Indirect	10/23/2026	P · Purchase	+28.38K	$26.11	$740.98K	115.5%	24.56K	52.94K
Common Stock Indirect	10/26/2026	C · Conversion	+4.78M	—	—	9028.9%	52.94K	4.83M
Common Stock Indirect	10/26/2026	P · Purchase	+1.94M	$18.00	$35M	40.2%	4.83M	6.78M
Common Stock Indirect	10/26/2026	P · Purchase	+8.26K	$26.97	$222.80K	0.1%	6.78M	6.79M
Common Stock Indirect	10/27/2026	P · Purchase	+8.73K	$25.84	$225.56K	0.1%	6.79M	6.79M
Common Stock Indirect	10/27/2026	P · Purchase	+31.07K	$26.84	$833.84K	0.5%	6.79M	6.83M
Total			+6.83M		$37.65M

Derivative Transactions2

Series C Preferred Stock

Indirect

C · Conversion

Converts to

Common Stock

3.80M shares

−17.14M

Strike price

Held after

0.00

Exercisable

—

10/26/2026

Series D Preferred Stock

Indirect

C · Conversion

Converts to

Common Stock

977.68K shares

−4.41M

Strike price

Held after

0.00

Exercisable

—

10/26/2026

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Series C Preferred Stock Indirect	Common Stock3.80M shares	10/26/2026	C · Conversion	−17.14M		—	0.00
Series D Preferred Stock Indirect	Common Stock977.68K shares	10/26/2026	C · Conversion	−4.41M		—	0.00