THOMAS FRANK E

Filed: 10/6/2022ACC: 0001209191-22-053005

InsiderTHOMAS FRANK ECIK 1242616

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IssuerORCHARD THERAPEUTICS PLCCIK 1748907

Officer· See Remarks

Since Jan 2020

+532.81K

Net shares

Net buyer

$0.00

Total acquired

Open market trades

0B · 0S

Total transactions

1.93M acquired · 1.40M disposed

Non-Derivative Transactions0

No non-derivative transactions reported

Derivative Transactions16

Stock Option (Right to Buy)

Direct

D · Disposition

Converts to

Ordinary Shares

426.19K shares

−426.19K

Strike price

2.44

Held after

0.00

Exercisable

—

10/4/2022

Stock Option (Right to Buy)

Direct

A · Award

Converts to

Ordinary Shares

426.19K shares

+426.19K

Strike price

0.58

Held after

426.19K

Exercisable

—

10/4/2022

Stock Option (Right to Buy)

Direct

D · Disposition

Converts to

Ordinary Shares

184.23K shares

−184.23K

Strike price

9.06

Held after

0.00

Exercisable

—

10/4/2022

Stock Option (Right to Buy)

Direct

A · Award

Converts to

Ordinary Shares

184.23K shares

+184.23K

Strike price

0.58

Held after

184.23K

Exercisable

—

10/4/2022

Stock Option (Right to Buy)

Direct

D · Disposition

Converts to

Ordinary Shares

100K shares

−100K

Strike price

12.54

Held after

0.00

Exercisable

—

10/4/2022

Stock Option (Right to Buy)

Direct

A · Award

Converts to

Ordinary Shares

100K shares

+100K

Strike price

0.58

Held after

100K

Exercisable

—

10/4/2022

Stock Option (Right to Buy)

Direct

D · Disposition

Converts to

Ordinary Shares

200K shares

−200K

Strike price

13.58

Held after

0.00

Exercisable

—

10/4/2022

Stock Option (Right to Buy)

Direct

A · Award

Converts to

Ordinary Shares

200K shares

+200K

Strike price

0.58

Held after

200K

Exercisable

—

10/4/2022

Stock Option (Right to Buy)

Direct

D · Disposition

Converts to

Ordinary Shares

150K shares

−150K

Strike price

7.05

Held after

0.00

Exercisable

—

10/4/2022

Stock Option (Right to Buy)

Direct

A · Award

Converts to

Ordinary Shares

150K shares

+150K

Strike price

0.58

Held after

150K

Exercisable

—

10/4/2022

Stock Option (Right to Buy)

Direct

D · Disposition

Converts to

Ordinary Shares

310K shares

−310K

Strike price

5.98

Held after

0.00

Exercisable

—

10/4/2022

Stock Option (Right to Buy)

Direct

A · Award

Converts to

Ordinary Shares

310K shares

+310K

Strike price

0.58

Held after

310K

Exercisable

—

10/4/2022

Stock Option (Right to Buy)

Direct

D · Disposition

Converts to

Ordinary Shares

27.73K shares

−27.73K

Strike price

5.98

Held after

0.00

Exercisable

—

10/4/2022

Stock Option (Right to Buy)

Direct

A · Award

Converts to

Ordinary Shares

27.73K shares

+27.73K

Strike price

0.58

Held after

27.73K

Exercisable

—

10/4/2022

Stock Option (Right to Buy)

Direct

A · Award

Converts to

Ordinary Shares

457.81K shares

+457.81K

Strike price

0.58

Held after

457.81K

Exercisable

—

10/4/2022

Stock Option (Right to Buy)

Direct

A · Award

Converts to

Ordinary Shares

75K shares

+75K

Strike price

0.58

Held after

75K

Exercisable

—

10/4/2022

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Stock Option (Right to Buy) Direct	Ordinary Shares426.19K shares	10/4/2022	D · Disposition	−426.19K	2.44	—	0.00
Stock Option (Right to Buy) Direct	Ordinary Shares426.19K shares	10/4/2022	A · Award	+426.19K	0.58	—	426.19K
Stock Option (Right to Buy) Direct	Ordinary Shares184.23K shares	10/4/2022	D · Disposition	−184.23K	9.06	—	0.00
Stock Option (Right to Buy) Direct	Ordinary Shares184.23K shares	10/4/2022	A · Award	+184.23K	0.58	—	184.23K
Stock Option (Right to Buy) Direct	Ordinary Shares100K shares	10/4/2022	D · Disposition	−100K	12.54	—	0.00
Stock Option (Right to Buy) Direct	Ordinary Shares100K shares	10/4/2022	A · Award	+100K	0.58	—	100K
Stock Option (Right to Buy) Direct	Ordinary Shares200K shares	10/4/2022	D · Disposition	−200K	13.58	—	0.00
Stock Option (Right to Buy) Direct	Ordinary Shares200K shares	10/4/2022	A · Award	+200K	0.58	—	200K
Stock Option (Right to Buy) Direct	Ordinary Shares150K shares	10/4/2022	D · Disposition	−150K	7.05	—	0.00
Stock Option (Right to Buy) Direct	Ordinary Shares150K shares	10/4/2022	A · Award	+150K	0.58	—	150K
Stock Option (Right to Buy) Direct	Ordinary Shares310K shares	10/4/2022	D · Disposition	−310K	5.98	—	0.00
Stock Option (Right to Buy) Direct	Ordinary Shares310K shares	10/4/2022	A · Award	+310K	0.58	—	310K
Stock Option (Right to Buy) Direct	Ordinary Shares27.73K shares	10/4/2022	D · Disposition	−27.73K	5.98	—	0.00
Stock Option (Right to Buy) Direct	Ordinary Shares27.73K shares	10/4/2022	A · Award	+27.73K	0.58	—	27.73K
Stock Option (Right to Buy) Direct	Ordinary Shares457.81K shares	10/4/2022	A · Award	+457.81K	0.58	—	457.81K
Stock Option (Right to Buy) Direct	Ordinary Shares75K shares	10/4/2022	A · Award	+75K	0.58	—	75K