Filed: 11/17/2025ACC: 0001214659-25-016751
📋 What this filing means
TCG CROSSOVER MANAGEMENT, LLC filed this quarterly 13F‑HR report disclosing 40 equity positions with a total reported market value of $2.03B. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
40
Positions
$2.03B
Total AUM (reported)
108.08M
Total Shares
Allocation by class
COMM$1.31B64.3%
ADRS$725.34M35.7%
Portfolio Concentration
Top 3$849.23M41.8%
4–10$491.23M24.2%
11–25$539.41M26.5%
Rest$153.03M7.5%
Top 3 weight
41.8%
Top 10 weight
65.9%
Voting Authority Distribution
Total shares with voting rights: 108.08M
Sole
Full voting authority
108.08M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole40
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings40
Rows:
ABIVAX SA AMERICAN DEPOSITARY SHARES
SOLEShares7.11M
TypeSH
Market value$603.77M
29.70%
Sole
7.11M
Shared
0.00
None
0.00
CG ONCOLOGY INC
SOLEShares3.67M
TypeSH
Market value$147.84M
7.27%
Sole
3.67M
Shared
0.00
None
0.00
COGENT BIOSCIENCES INC
SOLEShares6.80M
TypeSH
Market value$97.62M
4.80%
Sole
6.80M
Shared
0.00
None
0.00
AMYLYX PHARMACEUTICALS INC
SOLEShares6.24M
TypeSH
Market value$84.85M
4.17%
Sole
6.24M
Shared
0.00
None
0.00
CENTESSA PHARMACEUTICALS PLC
SOLEShares3.14M
TypeSH
Market value$76.06M
3.74%
Sole
3.14M
Shared
0.00
None
0.00
TANGO THERAPEUTICS INC
SOLEShares8.54M
TypeSH
Market value$71.70M
3.53%
Sole
8.54M
Shared
0.00
None
0.00
OCULAR THERAPEUTIX INC
SOLEShares6.12M
TypeSH
Market value$71.51M
3.52%
Sole
6.12M
Shared
0.00
None
0.00
DIANTHUS THERAPEUTICS INC
SOLEShares1.68M
TypeSH
Market value$65.98M
3.25%
Sole
1.68M
Shared
0.00
None
0.00
TOURMALINE BIO INC
SOLEShares1.31M
TypeSH
Market value$62.74M
3.09%
Sole
1.31M
Shared
0.00
None
0.00
DYNE THERAPEUTICS INC
SOLEShares4.62M
TypeSH
Market value$58.38M
2.87%
Sole
4.62M
Shared
0.00
None
0.00
AGIOS PHARMACEUTICALS INC
SOLEShares1.43M
TypeSH
Market value$57.40M
2.82%
Sole
1.43M
Shared
0.00
None
0.00
EYEPOINT PHARMACEUTICALS INC
SOLEShares3.57M
TypeSH
Market value$50.87M
2.50%
Sole
3.57M
Shared
0.00
None
0.00
FULCRUM THERAPEUTICS INC
SOLEShares5.25M
TypeSH
Market value$48.30M
2.38%
Sole
5.25M
Shared
0.00
None
0.00
SAVARA INC
SOLEShares12.36M
TypeSH
Market value$44.13M
2.17%
Sole
12.36M
Shared
0.00
None
0.00
RAPT THERAPEUTICS INC
SOLEShares1.64M
TypeSH
Market value$42.20M
2.08%
Sole
1.64M
Shared
0.00
None
0.00
TYRA BIOSCIENCES INC
SOLEShares2.90M
TypeSH
Market value$40.54M
1.99%
Sole
2.90M
Shared
0.00
None
0.00
UPSTREAM BIO INC
SOLEShares2.12M
TypeSH
Market value$39.82M
1.96%
Sole
2.12M
Shared
0.00
None
0.00
LIQUIDIA TECHNOLOGIES INC
SOLEShares1.71M
TypeSH
Market value$38.89M
1.91%
Sole
1.71M
Shared
0.00
None
0.00
DISC MEDICINE INC
SOLEShares465.26K
TypeSH
Market value$30.74M
1.51%
Sole
465.26K
Shared
0.00
None
0.00
STRUCTURE THERAPEUTICS INC
SOLEShares1.06M
TypeSH
Market value$29.76M
1.46%
Sole
1.06M
Shared
0.00
None
0.00
XENCOR INC
SOLEShares2.45M
TypeSH
Market value$28.76M
1.41%
Sole
2.45M
Shared
0.00
None
0.00
LB PHARMACEUTICALS INC
SOLEShares1.75M
TypeSH
Market value$27.55M
1.36%
Sole
1.75M
Shared
0.00
None
0.00
REVOLUTION MEDICINES INC
SOLEShares436.47K
TypeSH
Market value$20.38M
1.00%
Sole
436.47K
Shared
0.00
None
0.00
ASTRIA THERAPEUTICS INC
SOLEShares2.76M
TypeSH
Market value$20.11M
0.99%
Sole
2.76M
Shared
0.00
None
0.00
KORRO BIO INC
SOLEShares416.30K
TypeSH
Market value$19.94M
0.98%
Sole
416.30K
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
ABIVAX SA AMERICAN DEPOSITARY SHARESSOLE | ADRS | 7.11M | SH | $603.77M 29.70% | 7.11M | 0.00 | 0.00 |
CG ONCOLOGY INCSOLE | COMM | 3.67M | SH | $147.84M 7.27% | 3.67M | 0.00 | 0.00 |
COGENT BIOSCIENCES INCSOLE | COMM | 6.80M | SH | $97.62M 4.80% | 6.80M | 0.00 | 0.00 |
AMYLYX PHARMACEUTICALS INCSOLE | COMM | 6.24M | SH | $84.85M 4.17% | 6.24M | 0.00 | 0.00 |
CENTESSA PHARMACEUTICALS PLCSOLE | ADRS | 3.14M | SH | $76.06M 3.74% | 3.14M | 0.00 | 0.00 |
TANGO THERAPEUTICS INCSOLE | COMM | 8.54M | SH | $71.70M 3.53% | 8.54M | 0.00 | 0.00 |
OCULAR THERAPEUTIX INCSOLE | COMM | 6.12M | SH | $71.51M 3.52% | 6.12M | 0.00 | 0.00 |
DIANTHUS THERAPEUTICS INCSOLE | COMM | 1.68M | SH | $65.98M 3.25% | 1.68M | 0.00 | 0.00 |
TOURMALINE BIO INCSOLE | COMM | 1.31M | SH | $62.74M 3.09% | 1.31M | 0.00 | 0.00 |
DYNE THERAPEUTICS INCSOLE | COMM | 4.62M | SH | $58.38M 2.87% | 4.62M | 0.00 | 0.00 |
AGIOS PHARMACEUTICALS INCSOLE | COMM | 1.43M | SH | $57.40M 2.82% | 1.43M | 0.00 | 0.00 |
EYEPOINT PHARMACEUTICALS INCSOLE | COMM | 3.57M | SH | $50.87M 2.50% | 3.57M | 0.00 | 0.00 |
FULCRUM THERAPEUTICS INCSOLE | COMM | 5.25M | SH | $48.30M 2.38% | 5.25M | 0.00 | 0.00 |
SAVARA INCSOLE | COMM | 12.36M | SH | $44.13M 2.17% | 12.36M | 0.00 | 0.00 |
RAPT THERAPEUTICS INCSOLE | COMM | 1.64M | SH | $42.20M 2.08% | 1.64M | 0.00 | 0.00 |
TYRA BIOSCIENCES INCSOLE | COMM | 2.90M | SH | $40.54M 1.99% | 2.90M | 0.00 | 0.00 |
UPSTREAM BIO INCSOLE | COMM | 2.12M | SH | $39.82M 1.96% | 2.12M | 0.00 | 0.00 |
LIQUIDIA TECHNOLOGIES INCSOLE | COMM | 1.71M | SH | $38.89M 1.91% | 1.71M | 0.00 | 0.00 |
DISC MEDICINE INCSOLE | COMM | 465.26K | SH | $30.74M 1.51% | 465.26K | 0.00 | 0.00 |
STRUCTURE THERAPEUTICS INCSOLE | ADRS | 1.06M | SH | $29.76M 1.46% | 1.06M | 0.00 | 0.00 |
XENCOR INCSOLE | COMM | 2.45M | SH | $28.76M 1.41% | 2.45M | 0.00 | 0.00 |
LB PHARMACEUTICALS INCSOLE | COMM | 1.75M | SH | $27.55M 1.36% | 1.75M | 0.00 | 0.00 |
REVOLUTION MEDICINES INCSOLE | COMM | 436.47K | SH | $20.38M 1.00% | 436.47K | 0.00 | 0.00 |
ASTRIA THERAPEUTICS INCSOLE | COMM | 2.76M | SH | $20.11M 0.99% | 2.76M | 0.00 | 0.00 |
KORRO BIO INCSOLE | COMM | 416.30K | SH | $19.94M 0.98% | 416.30K | 0.00 | 0.00 |
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