Filed: 8/14/2025ACC: 0001214659-25-012291
📋 What this filing means
TCG CROSSOVER MANAGEMENT, LLC filed this quarterly 13F‑HR report disclosing 38 equity positions with a total reported market value of $875.51M. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
38
Positions
$875.51M
Total AUM (reported)
99.73M
Total Shares
Allocation by class
COMM$751.55M85.8%
ADRS$123.96M14.2%
Portfolio Concentration
Top 3$200.40M22.9%
4–10$292.76M33.4%
11–25$332.54M38.0%
Rest$49.82M5.7%
Top 3 weight
22.9%
Top 10 weight
56.3%
Voting Authority Distribution
Total shares with voting rights: 99.73M
Sole
Full voting authority
99.73M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole38
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings38
Rows:
CG ONCOLOGY INC
SOLEShares3.67M
TypeSH
Market value$95.43M
10.90%
Sole
3.67M
Shared
0.00
None
0.00
TANGO THERAPEUTICS INC
SOLEShares10.74M
TypeSH
Market value$54.97M
6.28%
Sole
10.74M
Shared
0.00
None
0.00
COGENT BIOSCIENCES INC
SOLEShares6.96M
TypeSH
Market value$50.00M
5.71%
Sole
6.96M
Shared
0.00
None
0.00
OCULAR THERAPEUTIX INC
SOLEShares5.32M
TypeSH
Market value$49.36M
5.64%
Sole
5.32M
Shared
0.00
None
0.00
CIDARA THERAPEUTICS INC
SOLEShares1.01M
TypeSH
Market value$49.00M
5.60%
Sole
1.01M
Shared
0.00
None
0.00
ABIVAX SA AMERICAN DEPOSITARY SHARES
SOLEShares6.06M
TypeSH
Market value$46.33M
5.29%
Sole
6.06M
Shared
0.00
None
0.00
AMYLYX PHARMACEUTICALS INC
SOLEShares5.94M
TypeSH
Market value$38.10M
4.35%
Sole
5.94M
Shared
0.00
None
0.00
CENTESSA PHARMACEUTICALS PLC
SOLEShares2.89M
TypeSH
Market value$37.99M
4.34%
Sole
2.89M
Shared
0.00
None
0.00
FULCRUM THERAPEUTICS INC
SOLEShares5.25M
TypeSH
Market value$36.12M
4.13%
Sole
5.25M
Shared
0.00
None
0.00
DYNE THERAPEUTICS INC
SOLEShares3.77M
TypeSH
Market value$35.86M
4.10%
Sole
3.77M
Shared
0.00
None
0.00
EYEPOINT PHARMACEUTICALS INC
SOLEShares3.57M
TypeSH
Market value$33.62M
3.84%
Sole
3.57M
Shared
0.00
None
0.00
UPSTREAM BIO INC
SOLEShares2.80M
TypeSH
Market value$30.76M
3.51%
Sole
2.80M
Shared
0.00
None
0.00
SAVARA INC
SOLEShares12.36M
TypeSH
Market value$28.19M
3.22%
Sole
12.36M
Shared
0.00
None
0.00
DIANTHUS THERAPEUTICS INC
SOLEShares1.50M
TypeSH
Market value$27.98M
3.20%
Sole
1.50M
Shared
0.00
None
0.00
TYRA BIOSCIENCES INC
SOLEShares2.90M
TypeSH
Market value$27.73M
3.17%
Sole
2.90M
Shared
0.00
None
0.00
DISC MEDICINE INC
SOLEShares465.26K
TypeSH
Market value$24.64M
2.81%
Sole
465.26K
Shared
0.00
None
0.00
TOURMALINE BIO INC
SOLEShares1.48M
TypeSH
Market value$23.63M
2.70%
Sole
1.48M
Shared
0.00
None
0.00
Agios Pharmaceuticals, Inc.
SOLEShares697K
TypeSH
Market value$23.18M
2.65%
Sole
697K
Shared
0.00
None
0.00
STRUCTURE THERAPEUTICS INC
SOLEShares1.06M
TypeSH
Market value$22.05M
2.52%
Sole
1.06M
Shared
0.00
None
0.00
XENCOR INC
SOLEShares2.45M
TypeSH
Market value$19.27M
2.20%
Sole
2.45M
Shared
0.00
None
0.00
SILENCE THERAPEUTICS PLC
SOLEShares3.03M
TypeSH
Market value$17.59M
2.01%
Sole
3.03M
Shared
0.00
None
0.00
SOLENO THERAPEUTICS INC
SOLEShares186.25K
TypeSH
Market value$15.60M
1.78%
Sole
186.25K
Shared
0.00
None
0.00
ASTRIA THERAPEUTICS INC
SOLEShares2.76M
TypeSH
Market value$14.80M
1.69%
Sole
2.76M
Shared
0.00
None
0.00
RAPT Therapeutics, Inc.
SOLEShares1.64M
TypeSH
Market value$13.09M
1.50%
Sole
1.64M
Shared
0.00
None
0.00
THIRD HARMONIC BIO INC
SOLEShares1.92M
TypeSH
Market value$10.40M
1.19%
Sole
1.92M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
CG ONCOLOGY INCSOLE | COMM | 3.67M | SH | $95.43M 10.90% | 3.67M | 0.00 | 0.00 |
TANGO THERAPEUTICS INCSOLE | COMM | 10.74M | SH | $54.97M 6.28% | 10.74M | 0.00 | 0.00 |
COGENT BIOSCIENCES INCSOLE | COMM | 6.96M | SH | $50.00M 5.71% | 6.96M | 0.00 | 0.00 |
OCULAR THERAPEUTIX INCSOLE | COMM | 5.32M | SH | $49.36M 5.64% | 5.32M | 0.00 | 0.00 |
CIDARA THERAPEUTICS INCSOLE | COMM | 1.01M | SH | $49.00M 5.60% | 1.01M | 0.00 | 0.00 |
ABIVAX SA AMERICAN DEPOSITARY SHARESSOLE | ADRS | 6.06M | SH | $46.33M 5.29% | 6.06M | 0.00 | 0.00 |
AMYLYX PHARMACEUTICALS INCSOLE | COMM | 5.94M | SH | $38.10M 4.35% | 5.94M | 0.00 | 0.00 |
CENTESSA PHARMACEUTICALS PLCSOLE | ADRS | 2.89M | SH | $37.99M 4.34% | 2.89M | 0.00 | 0.00 |
FULCRUM THERAPEUTICS INCSOLE | COMM | 5.25M | SH | $36.12M 4.13% | 5.25M | 0.00 | 0.00 |
DYNE THERAPEUTICS INCSOLE | COMM | 3.77M | SH | $35.86M 4.10% | 3.77M | 0.00 | 0.00 |
EYEPOINT PHARMACEUTICALS INCSOLE | COMM | 3.57M | SH | $33.62M 3.84% | 3.57M | 0.00 | 0.00 |
UPSTREAM BIO INCSOLE | COMM | 2.80M | SH | $30.76M 3.51% | 2.80M | 0.00 | 0.00 |
SAVARA INCSOLE | COMM | 12.36M | SH | $28.19M 3.22% | 12.36M | 0.00 | 0.00 |
DIANTHUS THERAPEUTICS INCSOLE | COMM | 1.50M | SH | $27.98M 3.20% | 1.50M | 0.00 | 0.00 |
TYRA BIOSCIENCES INCSOLE | COMM | 2.90M | SH | $27.73M 3.17% | 2.90M | 0.00 | 0.00 |
DISC MEDICINE INCSOLE | COMM | 465.26K | SH | $24.64M 2.81% | 465.26K | 0.00 | 0.00 |
TOURMALINE BIO INCSOLE | COMM | 1.48M | SH | $23.63M 2.70% | 1.48M | 0.00 | 0.00 |
Agios Pharmaceuticals, Inc.SOLE | COMM | 697K | SH | $23.18M 2.65% | 697K | 0.00 | 0.00 |
STRUCTURE THERAPEUTICS INCSOLE | ADRS | 1.06M | SH | $22.05M 2.52% | 1.06M | 0.00 | 0.00 |
XENCOR INCSOLE | COMM | 2.45M | SH | $19.27M 2.20% | 2.45M | 0.00 | 0.00 |
SILENCE THERAPEUTICS PLCSOLE | ADRS | 3.03M | SH | $17.59M 2.01% | 3.03M | 0.00 | 0.00 |
SOLENO THERAPEUTICS INCSOLE | COMM | 186.25K | SH | $15.60M 1.78% | 186.25K | 0.00 | 0.00 |
ASTRIA THERAPEUTICS INCSOLE | COMM | 2.76M | SH | $14.80M 1.69% | 2.76M | 0.00 | 0.00 |
RAPT Therapeutics, Inc.SOLE | COMM | 1.64M | SH | $13.09M 1.50% | 1.64M | 0.00 | 0.00 |
THIRD HARMONIC BIO INCSOLE | COMM | 1.92M | SH | $10.40M 1.19% | 1.92M | 0.00 | 0.00 |
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