SZWARCBERG JAVIER B. (Chief Executive Officer) exercised options at SPRUCE BIOSCIENCES, INC.

Option exercise — a mechanical event triggered by vesting or expiry. Not a discretionary conviction trade.

M · 2 exercises

SZWARCBERG JAVIER B.

Filed: 12/17/2025ACC: 0001903669-25-000010

InsiderSZWARCBERG JAVIER B.CIK 1903669

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IssuerSPRUCE BIOSCIENCES, INC.CIK 1683553

DirectorOfficer· Chief Executive Officer

Since Jan 2022

-1.36K

Net shares

Net seller

$109.7K

Total sold

Open market trades

0B · 0S

Total transactions

4.34K acquired · 5.70K disposed

Non-Derivative Transactions4

Common Stock

Direct

M · Option Exercise

+1.48K

Price / share

—

Trade value

—

% of position

11.4%

12/15/2025

13K→14.48K

Common Stock

Direct

F · Tax Withholding

−752.00

Price / share

$80.67

Trade value

$60.66K

% of position

5.2%

12/15/2025

14.48K→13.73K

Common Stock

Direct

M · Option Exercise

+1.20K

Price / share

—

Trade value

—

% of position

8.7%

12/15/2025

13.73K→14.92K

Common Stock

Direct

F · Tax Withholding

−608.00

Price / share

$80.67

Trade value

$49.05K

% of position

4.1%

12/15/2025

14.92K→14.31K

Total

Net shares

+1.32K

Net value

-$109.71K

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Direct	12/15/2025	M · Option Exercise	+1.48K	—	—	11.4%	13K	14.48K
Common Stock Direct	12/15/2025	F · Tax Withholding	−752.00	$80.67	$60.66K	5.2%	14.48K	13.73K
Common Stock Direct	12/15/2025	M · Option Exercise	+1.20K	—	—	8.7%	13.73K	14.92K
Common Stock Direct	12/15/2025	F · Tax Withholding	−608.00	$80.67	$49.05K	4.1%	14.92K	14.31K
Total			+1.32K		-$109.71K

Derivative Transactions4

Employee Stock Option (right to buy)

Direct

A · Award

Converts to

Common Stock

1.67K shares

+1.67K

Strike price

104.13

Held after

1.67K

Exercisable

—

12/11/2025

Employee Stock Option (right to buy)

Direct

D · Disposition

Converts to

Common Stock

1.67K shares

−1.67K

Strike price

344.25

Held after

0.00

Exercisable

—

12/11/2025

Restricted Stock Units

Direct

M · Option Exercise

Converts to

Common Stock

1.48K shares

−1.48K

Strike price

Held after

1.48K

Exercisable

—

12/15/2025

Restricted Stock Units

Direct

M · Option Exercise

Converts to

Common Stock

1.20K shares

−1.20K

Strike price

Held after

2.39K

Exercisable

—

12/15/2025

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Employee Stock Option (right to buy) Direct	Common Stock1.67K shares	12/11/2025	A · Award	+1.67K	104.13	—	1.67K
Employee Stock Option (right to buy) Direct	Common Stock1.67K shares	12/11/2025	D · Disposition	−1.67K	344.25	—	0.00
Restricted Stock Units Direct	Common Stock1.48K shares	12/15/2025	M · Option Exercise	−1.48K	0	—	1.48K
Restricted Stock Units Direct	Common Stock1.20K shares	12/15/2025	M · Option Exercise	−1.20K	0	—	2.39K