STRUTHERS RICHARD SCOTT (See Remarks) reported 12 transactions at CRINETICS PHARMACEUTICALS, INC.

Review the transaction codes below to understand the nature of each event.

STRUTHERS RICHARD SCOTT

Filed: 9/1/2026ACC: 0001628280-26-059882

InsiderSTRUTHERS RICHARD SCOTTCIK 1746298

→

IssuerCRINETICS PHARMACEUTICALS, INC.CIK 1658247

DirectorOfficer· See Remarks

Since Jul 2018

-3.34M

Net shares

Net seller

$119.25M

Total sold

Open market trades

0B · 0S

Total transactions

3.34M disposed

Non-Derivative Transactions12

Common Stock

Direct

D · Disposition

−248.04K

Price / share

$85.00

Trade value

$21.08M

% of position

58.4%

9/1/2026

424.71K→176.66K

Common Stock

Indirect

D · Disposition

−1K

Price / share

$85.00

Trade value

$85K

% of position

New position

9/1/2026

1K→0.00

Common Stock

Indirect

D · Disposition

−136.81K

Price / share

$85.00

Trade value

$11.63M

% of position

New position

9/1/2026

136.81K→0.00

Common Stock

Indirect

D · Disposition

−106K

Price / share

$85.00

Trade value

$9.01M

% of position

New position

9/1/2026

106K→0.00

Common Stock

Indirect

D · Disposition

−110K

Price / share

$85.00

Trade value

$9.35M

% of position

New position

9/1/2026

110K→0.00

Common Stock

Indirect

D · Disposition

−100K

Price / share

$85.00

Trade value

$8.50M

% of position

New position

9/1/2026

100K→0.00

Common Stock

Indirect

D · Disposition

−111.10K

Price / share

$85.00

Trade value

$9.44M

% of position

New position

9/1/2026

111.10K→0.00

Common Stock

Indirect

D · Disposition

−111.10K

Price / share

$85.00

Trade value

$9.44M

% of position

New position

9/1/2026

111.10K→0.00

Common Stock

Indirect

D · Disposition

−111.10K

Price / share

$85.00

Trade value

$9.44M

% of position

New position

9/1/2026

111.10K→0.00

Common Stock

Indirect

D · Disposition

−111.10K

Price / share

$85.00

Trade value

$9.44M

% of position

New position

9/1/2026

111.10K→0.00

Common Stock

Indirect

D · Disposition

−80K

Price / share

$85.00

Trade value

$6.80M

% of position

New position

9/1/2026

80K→0.00

Common Stock

Direct

D · Disposition

−176.66K

Price / share

$85.00

Trade value

$15.02M

% of position

New position

9/1/2026

176.66K→0.00

Total

Net shares

−1.40M

Net value

-$119.25M

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Direct	9/1/2026	D · Disposition	−248.04K	$85.00	$21.08M	58.4%	424.71K	176.66K
Common Stock Indirect	9/1/2026	D · Disposition	−1K	$85.00	$85K	New position	1K	0.00
Common Stock Indirect	9/1/2026	D · Disposition	−136.81K	$85.00	$11.63M	New position	136.81K	0.00
Common Stock Indirect	9/1/2026	D · Disposition	−106K	$85.00	$9.01M	New position	106K	0.00
Common Stock Indirect	9/1/2026	D · Disposition	−110K	$85.00	$9.35M	New position	110K	0.00
Common Stock Indirect	9/1/2026	D · Disposition	−100K	$85.00	$8.50M	New position	100K	0.00
Common Stock Indirect	9/1/2026	D · Disposition	−111.10K	$85.00	$9.44M	New position	111.10K	0.00
Common Stock Indirect	9/1/2026	D · Disposition	−111.10K	$85.00	$9.44M	New position	111.10K	0.00
Common Stock Indirect	9/1/2026	D · Disposition	−111.10K	$85.00	$9.44M	New position	111.10K	0.00
Common Stock Indirect	9/1/2026	D · Disposition	−111.10K	$85.00	$9.44M	New position	111.10K	0.00
Common Stock Indirect	9/1/2026	D · Disposition	−80K	$85.00	$6.80M	New position	80K	0.00
Common Stock Direct	9/1/2026	D · Disposition	−176.66K	$85.00	$15.02M	New position	176.66K	0.00
Total			−1.40M		-$119.25M

Derivative Transactions8

Stock Option (Right to Buy)

Direct

D · Disposition

Converts to

Common Stock

172.28K shares

−172.28K

Strike price

25.19

Held after

0.00

Exercisable

—

9/1/2026

Stock Option (Right to Buy)

Direct

D · Disposition

Converts to

Common Stock

195.58K shares

−195.58K

Strike price

22.61

Held after

0.00

Exercisable

—

9/1/2026

Stock Option (Right to Buy)

Direct

D · Disposition

Converts to

Common Stock

259.06K shares

−259.06K

Strike price

15.29

Held after

0.00

Exercisable

—

9/1/2026

Stock Option (Right to Buy)

Direct

D · Disposition

Converts to

Common Stock

244.21K shares

−244.21K

Strike price

20.02

Held after

0.00

Exercisable

—

9/1/2026

Stock Option (Right to Buy)

Direct

D · Disposition

Converts to

Common Stock

287.70K shares

−287.70K

Strike price

19.64

Held after

0.00

Exercisable

—

9/1/2026

Stock Option (Right to Buy)

Direct

D · Disposition

Converts to

Common Stock

240K shares

−240K

Strike price

43.51

Held after

0.00

Exercisable

—

9/1/2026

Stock Option (Right to Buy)

Direct

D · Disposition

Converts to

Common Stock

313K shares

−313K

Strike price

36.86

Held after

0.00

Exercisable

—

9/1/2026

Stock Option (Right to Buy)

Direct

D · Disposition

Converts to

Common Stock

228K shares

−228K

Strike price

43.79

Held after

0.00

Exercisable

—

9/1/2026

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable
Stock Option (Right to Buy) Direct	Common Stock172.28K shares	9/1/2026	D · Disposition	−172.28K	25.19	—
Stock Option (Right to Buy) Direct	Common Stock195.58K shares	9/1/2026	D · Disposition	−195.58K	22.61	—
Stock Option (Right to Buy) Direct	Common Stock259.06K shares	9/1/2026	D · Disposition	−259.06K	15.29	—
Stock Option (Right to Buy) Direct	Common Stock244.21K shares	9/1/2026	D · Disposition	−244.21K	20.02	—
Stock Option (Right to Buy) Direct	Common Stock287.70K shares	9/1/2026	D · Disposition	−287.70K	19.64	—
Stock Option (Right to Buy) Direct	Common Stock240K shares	9/1/2026	D · Disposition	−240K	43.51	—
Stock Option (Right to Buy) Direct	Common Stock313K shares	9/1/2026	D · Disposition	−313K	36.86	—
Stock Option (Right to Buy) Direct	Common Stock228K shares	9/1/2026	D · Disposition	−228K	43.79	—