Filed: 11/12/2025ACC: 0001193125-25-277769
📋 What this filing means
SR ONE CAPITAL MANAGEMENT, LP filed this quarterly 13F‑HR report disclosing 12 equity positions with a total reported market value of $691.41M. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
12
Positions
$691.41M
Total AUM (reported)
33.26M
Total Shares
Allocation by class
COMMON STOCK$548.50M79.3%
COMMON SHARES$137.24M19.8%
ORDINARY SHARES$5.67M0.8%
Portfolio Concentration
Top 3$433.83M62.7%
4–10$246.81M35.7%
11–25$10.78M1.6%
Top 3 weight
62.7%
Top 10 weight
98.4%
Voting Authority Distribution
Total shares with voting rights: 33.26M
Sole
Full voting authority
33.26M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole12
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings12
Rows:
Arcellx, Inc.
SOLEShares2.35M
TypeSH
Market value$192.66M
27.86%
Sole
2.35M
Shared
0.00
None
0.00
CRISPR Therapeutics AG
SOLEShares2.04M
TypeSH
Market value$132.13M
19.11%
Sole
2.04M
Shared
0.00
None
0.00
Zenas BioPharma, Inc
SOLEShares4.91M
TypeSH
Market value$109.04M
15.77%
Sole
4.91M
Shared
0.00
None
0.00
Mineralys Therapeutics Inc.
SOLEShares2.11M
TypeSH
Market value$80.16M
11.59%
Sole
2.11M
Shared
0.00
None
0.00
ORIC Pharmaceuticals, Inc.
SOLEShares4.51M
TypeSH
Market value$54.18M
7.84%
Sole
4.51M
Shared
0.00
None
0.00
Design Therapeutics, Inc.
SOLEShares6.53M
TypeSH
Market value$49.14M
7.11%
Sole
6.53M
Shared
0.00
None
0.00
ARS Pharmaceuticals, Inc.
SOLEShares4.01M
TypeSH
Market value$40.33M
5.83%
Sole
4.01M
Shared
0.00
None
0.00
Oruka Therapeutics, Inc
SOLEShares430.33K
TypeSH
Market value$8.28M
1.20%
Sole
430.33K
Shared
0.00
None
0.00
Alumis Inc.
SOLEShares1.96M
TypeSH
Market value$7.82M
1.13%
Sole
1.96M
Shared
0.00
None
0.00
Nkarta, Inc.
SOLEShares3.33M
TypeSH
Market value$6.90M
1.00%
Sole
3.33M
Shared
0.00
None
0.00
Oculis Holding AG
SOLEShares322.50K
TypeSH
Market value$5.67M
0.82%
Sole
322.50K
Shared
0.00
None
0.00
enGene Holdings Inc.
SOLEShares747.75K
TypeSH
Market value$5.11M
0.74%
Sole
747.75K
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
Arcellx, Inc.SOLE | Common Stock | 2.35M | SH | $192.66M 27.86% | 2.35M | 0.00 | 0.00 |
CRISPR Therapeutics AGSOLE | Common Shares | 2.04M | SH | $132.13M 19.11% | 2.04M | 0.00 | 0.00 |
Zenas BioPharma, IncSOLE | Common Stock | 4.91M | SH | $109.04M 15.77% | 4.91M | 0.00 | 0.00 |
Mineralys Therapeutics Inc.SOLE | Common Stock | 2.11M | SH | $80.16M 11.59% | 2.11M | 0.00 | 0.00 |
ORIC Pharmaceuticals, Inc.SOLE | Common Stock | 4.51M | SH | $54.18M 7.84% | 4.51M | 0.00 | 0.00 |
Design Therapeutics, Inc.SOLE | Common Stock | 6.53M | SH | $49.14M 7.11% | 6.53M | 0.00 | 0.00 |
ARS Pharmaceuticals, Inc.SOLE | Common Stock | 4.01M | SH | $40.33M 5.83% | 4.01M | 0.00 | 0.00 |
Oruka Therapeutics, IncSOLE | Common Stock | 430.33K | SH | $8.28M 1.20% | 430.33K | 0.00 | 0.00 |
Alumis Inc.SOLE | Common Stock | 1.96M | SH | $7.82M 1.13% | 1.96M | 0.00 | 0.00 |
Nkarta, Inc.SOLE | Common Stock | 3.33M | SH | $6.90M 1.00% | 3.33M | 0.00 | 0.00 |
Oculis Holding AGSOLE | Ordinary Shares | 322.50K | SH | $5.67M 0.82% | 322.50K | 0.00 | 0.00 |
enGene Holdings Inc.SOLE | Common Shares | 747.75K | SH | $5.11M 0.74% | 747.75K | 0.00 | 0.00 |