SERAFIN ANDREW (Chief Business Officer) exercised options at HARMONY BIOSCIENCES HOLDINGS, INC.

Option exercise — a mechanical event triggered by vesting or expiry. Not a discretionary conviction trade.

M · 2 exercises

SERAFIN ANDREW

Filed: 1/26/2026ACC: 0001821460-26-000002

InsiderSERAFIN ANDREWCIK 1821460

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IssuerHARMONY BIOSCIENCES HOLDINGS, INC.CIK 1802665

Officer· Chief Business Officer

Since Aug 2020

+52.56K

Net shares

Net buyer

$82.6K

Total sold

Open market trades

0B · 0S

Total transactions

59.90K acquired · 7.34K disposed

Non-Derivative Transactions4

Common Stock

Direct

M · Option Exercise

+2.50K

Price / share

—

Trade value

—

% of position

New position

1/24/2026

0.00→2.50K

Common Stock

Direct

F · Tax Withholding

−1.12K

Price / share

$36.82

Trade value

$41.09K

% of position

44.6%

1/24/2026

2.50K→1.38K

Common Stock

Direct

M · Option Exercise

+2.60K

Price / share

—

Trade value

—

% of position

New position

1/25/2026

0.00→2.60K

Common Stock

Direct

F · Tax Withholding

−1.13K

Price / share

$36.82

Trade value

$41.46K

% of position

43.3%

1/25/2026

2.60K→1.47K

Total

Net shares

+2.86K

Net value

-$82.55K

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Direct	1/24/2026	M · Option Exercise	+2.50K	—	—	New position	0.00	2.50K
Common Stock Direct	1/24/2026	F · Tax Withholding	−1.12K	$36.82	$41.09K	44.6%	2.50K	1.38K
Common Stock Direct	1/25/2026	M · Option Exercise	+2.60K	—	—	New position	0.00	2.60K
Common Stock Direct	1/25/2026	F · Tax Withholding	−1.13K	$36.82	$41.46K	43.3%	2.60K	1.47K
Total			+2.86K		-$82.55K

Derivative Transactions4

Stock Option

Direct

A · Award

Converts to

Common Stock

42.60K shares

+42.60K

Strike price

36.76

Held after

42.60K

Exercisable

—

1/22/2026

Restricted Stock Units

Direct

A · Award

Converts to

Common Stock

12.20K shares

+12.20K

Strike price

Held after

12.20K

Exercisable

—

1/22/2026

Restricted Stock Units

Direct

M · Option Exercise

Converts to

Common Stock

2.50K shares

−2.50K

Strike price

Held after

Exercisable

—

1/24/2026

Restricted Stock Units

Direct

M · Option Exercise

Converts to

Common Stock

2.60K shares

−2.60K

Strike price

Held after

7.80K

Exercisable

—

1/25/2026

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Stock Option Direct	Common Stock42.60K shares	1/22/2026	A · Award	+42.60K	36.76	—	42.60K
Restricted Stock Units Direct	Common Stock12.20K shares	1/22/2026	A · Award	+12.20K		—	12.20K
Restricted Stock Units Direct	Common Stock2.50K shares	1/24/2026	M · Option Exercise	−2.50K		—	5K
Restricted Stock Units Direct	Common Stock2.60K shares	1/25/2026	M · Option Exercise	−2.60K		—	7.80K