SACHDEV AMIT (EVP, CRO) sold 49.9% of their position (58.61K shares) of VERTEX PHARMACEUTICALS INC / MA on the open market

Open‑market sale worth $27.48M — a major position exit. Review remaining holdings and any 10b5‑1 plan disclosures.

S · 8 sales

SACHDEV AMIT

Filed: 2/23/2026ACC: 0000875320-26-000102

InsiderSACHDEV AMITCIK 1406338

→

IssuerVERTEX PHARMACEUTICALS INC / MACIK 875320

Officer· EVP, CRO

Since Jun 2018

-58.61K

Net shares

Net seller

$27.48M

Total sold

Open market trades

0B · 8S

Total transactions

48.51K acquired · 107.12K disposed

Non-Derivative Transactions10

Common Stock

Direct

M · Option Exercise

+23.48K

Price / share

$155.57

Trade value

$3.65M

% of position

34.0%

2/19/2026

69.04K→92.52K

Common Stock

Direct

M · Option Exercise

+25.03K

Price / share

$187.53

Trade value

$4.69M

% of position

27.0%

2/19/2026

92.52K→117.55K

Common Stock

Direct

S · Sale

−920.00

Price / share

$463.91

Trade value

$426.80K

% of position

0.8%

2/19/2026

117.55K→116.63K

Common Stock

Direct

S · Sale

−2.73K

Price / share

$465.05

Trade value

$1.27M

% of position

2.3%

2/19/2026

116.63K→113.90K

Common Stock

Direct

S · Sale

−1.85K

Price / share

$465.80

Trade value

$860.80K

% of position

1.6%

2/19/2026

113.90K→112.05K

Common Stock

Direct

S · Sale

−10.26K

Price / share

$467.75

Trade value

$4.80M

% of position

9.2%

2/19/2026

112.05K→101.79K

Common Stock

Direct

S · Sale

−19.66K

Price / share

$468.57

Trade value

$9.21M

% of position

19.3%

2/19/2026

101.79K→82.12K

Common Stock

Direct

S · Sale

−7.24K

Price / share

$469.61

Trade value

$3.40M

% of position

8.8%

2/19/2026

82.12K→74.88K

Common Stock

Direct

S · Sale

−11.71K

Price / share

$470.54

Trade value

$5.51M

% of position

15.6%

2/19/2026

74.88K→63.17K

Common Stock

Direct

S · Sale

−4.24K

Price / share

$471.43

Trade value

$2M

% of position

6.7%

2/19/2026

63.17K→58.93K

Total

Net shares

−10.11K

Net value

-$19.13M

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Direct	2/19/2026	M · Option Exercise	+23.48K	$155.57	$3.65M	34.0%	69.04K	92.52K
Common Stock Direct	2/19/2026	M · Option Exercise	+25.03K	$187.53	$4.69M	27.0%	92.52K	117.55K
Common Stock Direct	2/19/2026	S · Sale	−920.00	$463.91	$426.80K	0.8%	117.55K	116.63K
Common Stock Direct	2/19/2026	S · Sale	−2.73K	$465.05	$1.27M	2.3%	116.63K	113.90K
Common Stock Direct	2/19/2026	S · Sale	−1.85K	$465.80	$860.80K	1.6%	113.90K	112.05K
Common Stock Direct	2/19/2026	S · Sale	−10.26K	$467.75	$4.80M	9.2%	112.05K	101.79K
Common Stock Direct	2/19/2026	S · Sale	−19.66K	$468.57	$9.21M	19.3%	101.79K	82.12K
Common Stock Direct	2/19/2026	S · Sale	−7.24K	$469.61	$3.40M	8.8%	82.12K	74.88K
Common Stock Direct	2/19/2026	S · Sale	−11.71K	$470.54	$5.51M	15.6%	74.88K	63.17K
Common Stock Direct	2/19/2026	S · Sale	−4.24K	$471.43	$2M	6.7%	63.17K	58.93K
Total			−10.11K		-$19.13M

Derivative Transactions2

Stock Option (Right to Buy)

Direct

M · Option Exercise

Converts to

Common Stock

23.48K shares

−23.48K

Strike price

155.57

Held after

0.00

Exercisable

—

2/19/2026

Stock Option (Right to Buy)

Direct

M · Option Exercise

Converts to

Common Stock

25.03K shares

−25.03K

Strike price

187.53

Held after

0.00

Exercisable

—

2/19/2026

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Stock Option (Right to Buy) Direct	Common Stock23.48K shares	2/19/2026	M · Option Exercise	−23.48K	155.57	—	0.00
Stock Option (Right to Buy) Direct	Common Stock25.03K shares	2/19/2026	M · Option Exercise	−25.03K	187.53	—	0.00

Non-Derivative Holdings (Post-Transaction)2

Common Stock

Indirect

Shares owned9.30K

Common Stock

Indirect

Shares owned882.00

Total

10.18K indirect10.18K

Security Title	Shares Owned	Ownership Type
Common Stock	9.30K	Indirect
Common Stock	882.00	Indirect
Total	10.18K	10.18K indirect

Derivative Holdings (Post-Transaction)0

No derivative holdings reported