RUSSO RENE

Filed: 11/25/2025ACC: 0001193125-25-297203

InsiderRUSSO RENECIK 1722066

→

IssuerXILIO THERAPEUTICS, INC.CIK 1840233

DirectorOfficer10% Owner· CEO and President

Since Oct 2021

+2.08M

Net shares

Net buyer

$0.00

Total acquired

Open market trades

0B · 0S

Total transactions

4.27M acquired · 2.20M disposed

Non-Derivative Transactions0

No non-derivative transactions reported

Derivative Transactions17

Stock Option (right to buy)

Direct

A · Award

Converts to

Common Stock

2.08M shares

+2.08M

Strike price

0.841

Held after

2.08M

Exercisable

—

11/21/2025

Stock Option (right to buy)

Direct

D · Disposition

Converts to

Common Stock

239.70K shares

−239.70K

Strike price

5.51

Held after

0.00

Exercisable

—

11/21/2025

Stock Option (right to buy)

Direct

A · Award

Converts to

Common Stock

239.70K shares

+239.70K

Strike price

1.50

Held after

239.70K

Exercisable

—

11/21/2025

Stock Option (right to buy)

Direct

D · Disposition

Converts to

Common Stock

473.33K shares

−473.33K

Strike price

5.89

Held after

0.00

Exercisable

—

11/21/2025

Stock Option (right to buy)

Direct

A · Award

Converts to

Common Stock

473.33K shares

+473.33K

Strike price

1.50

Held after

473.33K

Exercisable

—

11/21/2025

Stock Option (right to buy)

Direct

D · Disposition

Converts to

Common Stock

135.13K shares

−135.13K

Strike price

11.69

Held after

0.00

Exercisable

—

11/21/2025

Stock Option (right to buy)

Direct

A · Award

Converts to

Common Stock

135.13K shares

+135.13K

Strike price

1.50

Held after

135.13K

Exercisable

—

11/21/2025

Stock Option (right to buy)

Direct

D · Disposition

Converts to

Common Stock

50.04K shares

−50.04K

Strike price

16.00

Held after

0.00

Exercisable

—

11/21/2025

Stock Option (right to buy)

Direct

A · Award

Converts to

Common Stock

50.04K shares

+50.04K

Strike price

1.50

Held after

50.04K

Exercisable

—

11/21/2025

Stock Option (right to buy)

Direct

D · Disposition

Converts to

Common Stock

100K shares

−100K

Strike price

13.83

Held after

0.00

Exercisable

—

11/21/2025

Stock Option (right to buy)

Direct

A · Award

Converts to

Common Stock

100K shares

+100K

Strike price

1.50

Held after

100K

Exercisable

—

11/21/2025

Stock Option (right to buy)

Direct

D · Disposition

Converts to

Common Stock

150K shares

−150K

Strike price

12.66

Held after

0.00

Exercisable

—

11/21/2025

Stock Option (right to buy)

Direct

A · Award

Converts to

Common Stock

150K shares

+150K

Strike price

1.50

Held after

150K

Exercisable

—

11/21/2025

Stock Option (right to buy)

Direct

D · Disposition

Converts to

Common Stock

350K shares

−350K

Strike price

2.69

Held after

0.00

Exercisable

—

11/21/2025

Stock Option (right to buy)

Direct

A · Award

Converts to

Common Stock

350K shares

+350K

Strike price

1.50

Held after

350K

Exercisable

—

11/21/2025

Stock Option (right to buy)

Direct

D · Disposition

Converts to

Common Stock

700K shares

−700K

Strike price

2.785

Held after

0.00

Exercisable

—

11/21/2025

Stock Option (right to buy)

Direct

A · Award

Converts to

Common Stock

700K shares

+700K

Strike price

1.50

Held after

700K

Exercisable

—

11/21/2025

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Stock Option (right to buy) Direct	Common Stock2.08M shares	11/21/2025	A · Award	+2.08M	0.841	—	2.08M
Stock Option (right to buy) Direct	Common Stock239.70K shares	11/21/2025	D · Disposition	−239.70K	5.51	—	0.00
Stock Option (right to buy) Direct	Common Stock239.70K shares	11/21/2025	A · Award	+239.70K	1.50	—	239.70K
Stock Option (right to buy) Direct	Common Stock473.33K shares	11/21/2025	D · Disposition	−473.33K	5.89	—	0.00
Stock Option (right to buy) Direct	Common Stock473.33K shares	11/21/2025	A · Award	+473.33K	1.50	—	473.33K
Stock Option (right to buy) Direct	Common Stock135.13K shares	11/21/2025	D · Disposition	−135.13K	11.69	—	0.00
Stock Option (right to buy) Direct	Common Stock135.13K shares	11/21/2025	A · Award	+135.13K	1.50	—	135.13K
Stock Option (right to buy) Direct	Common Stock50.04K shares	11/21/2025	D · Disposition	−50.04K	16.00	—	0.00
Stock Option (right to buy) Direct	Common Stock50.04K shares	11/21/2025	A · Award	+50.04K	1.50	—	50.04K
Stock Option (right to buy) Direct	Common Stock100K shares	11/21/2025	D · Disposition	−100K	13.83	—	0.00
Stock Option (right to buy) Direct	Common Stock100K shares	11/21/2025	A · Award	+100K	1.50	—	100K
Stock Option (right to buy) Direct	Common Stock150K shares	11/21/2025	D · Disposition	−150K	12.66	—	0.00
Stock Option (right to buy) Direct	Common Stock150K shares	11/21/2025	A · Award	+150K	1.50	—	150K
Stock Option (right to buy) Direct	Common Stock350K shares	11/21/2025	D · Disposition	−350K	2.69	—	0.00
Stock Option (right to buy) Direct	Common Stock350K shares	11/21/2025	A · Award	+350K	1.50	—	350K
Stock Option (right to buy) Direct	Common Stock700K shares	11/21/2025	D · Disposition	−700K	2.785	—	0.00
Stock Option (right to buy) Direct	Common Stock700K shares	11/21/2025	A · Award	+700K	1.50	—	700K