Filed: 2/17/2026ACC: 0001493215-26-000060
📋 What this filing means
RTW INVESTMENTS, LP filed this quarterly 13F‑HR report disclosing 91 equity positions with a total reported market value of $9.98B. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
91
Positions
$9.98B
Total AUM (reported)
258.59M
Total Shares
Allocation by class
COM$7.02B70.3%
COM PAR $.01$842.85M8.4%
SPONSORED ADR$566.38M5.7%
COM NEW$511.33M5.1%
SHS$286.79M2.9%
SPONSORED ADS$226.59M2.3%
ADS$175.07M1.8%
Portfolio Concentration
Top 3$2.59B26.0%
4–10$2.45B24.5%
11–25$2.52B25.3%
Rest$2.42B24.3%
Top 3 weight
26.0%
Top 10 weight
50.5%
Voting Authority Distribution
Total shares with voting rights: 258.59M
Sole
Full voting authority
258.59M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole91
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings91
Rows:
MADRIGAL PHARMACEUTICALS INC
SOLEShares1.99M
TypeSH
Market value$1.16B
11.63%
Sole
1.99M
Shared
0.00
None
0.00
INSMED INC
SOLEShares4.84M
TypeSH
Market value$842.85M
8.44%
Sole
4.84M
Shared
0.00
None
0.00
PTC THERAPEUTICS INC
SOLEShares7.75M
TypeSH
Market value$588.42M
5.89%
Sole
7.75M
Shared
0.00
None
0.00
ARGENX SE
SOLEShares673.50K
TypeSH
Market value$566.38M
5.67%
Sole
673.50K
Shared
0.00
None
0.00
PROTAGONIST THERAPEUTICS INC
SOLEShares5.06M
TypeSH
Market value$441.86M
4.43%
Sole
5.06M
Shared
0.00
None
0.00
NATERA INC
SOLEShares1.50M
TypeSH
Market value$343.63M
3.44%
Sole
1.50M
Shared
0.00
None
0.00
RADNET INC
SOLEShares3.94M
TypeSH
Market value$281.01M
2.81%
Sole
3.94M
Shared
0.00
None
0.00
TARSUS PHARMACEUTICALS INC
SOLEShares3.34M
TypeSH
Market value$273.10M
2.74%
Sole
3.34M
Shared
0.00
None
0.00
COGENT BIOSCIENCES INC
SOLEShares7.59M
TypeSH
Market value$269.68M
2.70%
Sole
7.59M
Shared
0.00
None
0.00
PENUMBRA INC
SOLEShares866.50K
TypeSH
Market value$269.40M
2.70%
Sole
866.50K
Shared
0.00
None
0.00
IRHYTHM TECHNOLOGIES INC
SOLEShares1.18M
TypeSH
Market value$209.73M
2.10%
Sole
1.18M
Shared
0.00
None
0.00
APOGEE THERAPEUTICS INC
SOLEShares2.71M
TypeSH
Market value$204.71M
2.05%
Sole
2.71M
Shared
0.00
None
0.00
APELLIS PHARMACEUTICALS INC
SOLEShares7.67M
TypeSH
Market value$192.59M
1.93%
Sole
7.67M
Shared
0.00
None
0.00
ACADIA PHARMACEUTICALS INC
SOLEShares7.14M
TypeSH
Market value$190.83M
1.91%
Sole
7.14M
Shared
0.00
None
0.00
ESTABLISHMENT LABS HLDGS INC
SOLEShares2.59M
TypeSH
Market value$188.67M
1.89%
Sole
2.59M
Shared
0.00
None
0.00
STOKE THERAPEUTICS INC
SOLEShares5.55M
TypeSH
Market value$176.06M
1.76%
Sole
5.55M
Shared
0.00
None
0.00
REPLIGEN CORP
SOLEShares1.06M
TypeSH
Market value$174.35M
1.75%
Sole
1.06M
Shared
0.00
None
0.00
CYTOKINETICS INC
SOLEShares2.72M
TypeSH
Market value$172.90M
1.73%
Sole
2.72M
Shared
0.00
None
0.00
IMMUNOCORE HLDGS PLC
SOLEShares4.87M
TypeSH
Market value$169.03M
1.69%
Sole
4.87M
Shared
0.00
None
0.00
AXSOME THERAPEUTICS INC
SOLEShares888K
TypeSH
Market value$162.18M
1.62%
Sole
888K
Shared
0.00
None
0.00
GUARDANT HEALTH INC
SOLEShares1.48M
TypeSH
Market value$151.27M
1.52%
Sole
1.48M
Shared
0.00
None
0.00
NEUROCRINE BIOSCIENCES INC
SOLEShares1.06M
TypeSH
Market value$150.63M
1.51%
Sole
1.06M
Shared
0.00
None
0.00
SPYRE THERAPEUTICS INC
SOLEShares4.17M
TypeSH
Market value$136.67M
1.37%
Sole
4.17M
Shared
0.00
None
0.00
ZAI LAB LTD
SOLEShares6.96M
TypeSH
Market value$122.76M
1.23%
Sole
6.96M
Shared
0.00
None
0.00
IMMATICS N.V
SOLEShares11.43M
TypeSH
Market value$120.05M
1.20%
Sole
11.43M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
MADRIGAL PHARMACEUTICALS INCSOLE | COM | 1.99M | SH | $1.16B 11.63% | 1.99M | 0.00 | 0.00 |
INSMED INCSOLE | COM PAR $.01 | 4.84M | SH | $842.85M 8.44% | 4.84M | 0.00 | 0.00 |
PTC THERAPEUTICS INCSOLE | COM | 7.75M | SH | $588.42M 5.89% | 7.75M | 0.00 | 0.00 |
ARGENX SESOLE | SPONSORED ADR | 673.50K | SH | $566.38M 5.67% | 673.50K | 0.00 | 0.00 |
PROTAGONIST THERAPEUTICS INCSOLE | COM | 5.06M | SH | $441.86M 4.43% | 5.06M | 0.00 | 0.00 |
NATERA INCSOLE | COM | 1.50M | SH | $343.63M 3.44% | 1.50M | 0.00 | 0.00 |
RADNET INCSOLE | COM | 3.94M | SH | $281.01M 2.81% | 3.94M | 0.00 | 0.00 |
TARSUS PHARMACEUTICALS INCSOLE | COM | 3.34M | SH | $273.10M 2.74% | 3.34M | 0.00 | 0.00 |
COGENT BIOSCIENCES INCSOLE | COM | 7.59M | SH | $269.68M 2.70% | 7.59M | 0.00 | 0.00 |
PENUMBRA INCSOLE | COM | 866.50K | SH | $269.40M 2.70% | 866.50K | 0.00 | 0.00 |
IRHYTHM TECHNOLOGIES INCSOLE | COM | 1.18M | SH | $209.73M 2.10% | 1.18M | 0.00 | 0.00 |
APOGEE THERAPEUTICS INCSOLE | COM | 2.71M | SH | $204.71M 2.05% | 2.71M | 0.00 | 0.00 |
APELLIS PHARMACEUTICALS INCSOLE | COM | 7.67M | SH | $192.59M 1.93% | 7.67M | 0.00 | 0.00 |
ACADIA PHARMACEUTICALS INCSOLE | COM | 7.14M | SH | $190.83M 1.91% | 7.14M | 0.00 | 0.00 |
ESTABLISHMENT LABS HLDGS INCSOLE | COM | 2.59M | SH | $188.67M 1.89% | 2.59M | 0.00 | 0.00 |
STOKE THERAPEUTICS INCSOLE | COM | 5.55M | SH | $176.06M 1.76% | 5.55M | 0.00 | 0.00 |
REPLIGEN CORPSOLE | COM | 1.06M | SH | $174.35M 1.75% | 1.06M | 0.00 | 0.00 |
CYTOKINETICS INCSOLE | COM NEW | 2.72M | SH | $172.90M 1.73% | 2.72M | 0.00 | 0.00 |
IMMUNOCORE HLDGS PLCSOLE | ADS | 4.87M | SH | $169.03M 1.69% | 4.87M | 0.00 | 0.00 |
AXSOME THERAPEUTICS INCSOLE | COM | 888K | SH | $162.18M 1.62% | 888K | 0.00 | 0.00 |
GUARDANT HEALTH INCSOLE | COM | 1.48M | SH | $151.27M 1.52% | 1.48M | 0.00 | 0.00 |
NEUROCRINE BIOSCIENCES INCSOLE | COM | 1.06M | SH | $150.63M 1.51% | 1.06M | 0.00 | 0.00 |
SPYRE THERAPEUTICS INCSOLE | COM NEW | 4.17M | SH | $136.67M 1.37% | 4.17M | 0.00 | 0.00 |
ZAI LAB LTDSOLE | ADR | 6.96M | SH | $122.76M 1.23% | 6.96M | 0.00 | 0.00 |
IMMATICS N.VSOLE | SHS | 11.43M | SH | $120.05M 1.20% | 11.43M | 0.00 | 0.00 |
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