Filed: 11/14/2025ACC: 0001493215-25-000054
📋 What this filing means
RTW INVESTMENTS, LP filed this quarterly 13F‑HR report disclosing 74 equity positions with a total reported market value of $8.12B. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
74
Positions
$8.12B
Total AUM (reported)
250.17M
Total Shares
Allocation by class
COM$5.75B70.9%
SPONSORED ADR$496.74M6.1%
COM PAR $.01$444.21M5.5%
COM NEW$402.03M5.0%
SHS$390.15M4.8%
ADS$176.92M2.2%
SPONSORED ADS$158.31M2.0%
Portfolio Concentration
Top 3$1.91B23.5%
4–10$2.36B29.1%
11–25$2.16B26.7%
Rest$1.68B20.7%
Top 3 weight
23.5%
Top 10 weight
52.6%
Voting Authority Distribution
Total shares with voting rights: 250.17M
Sole
Full voting authority
250.17M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole74
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings74
Rows:
MADRIGAL PHARMACEUTICALS INC
SOLEShares1.99M
TypeSH
Market value$914.42M
11.27%
Sole
1.99M
Shared
0.00
None
0.00
ARGENX SE
SOLEShares673.50K
TypeSH
Market value$496.74M
6.12%
Sole
673.50K
Shared
0.00
None
0.00
AVIDITY BIOSCIENCES INC
SOLEShares11.37M
TypeSH
Market value$495.51M
6.11%
Sole
11.37M
Shared
0.00
None
0.00
PTC THERAPEUTICS INC
SOLEShares7.75M
TypeSH
Market value$475.40M
5.86%
Sole
7.75M
Shared
0.00
None
0.00
INSMED INC
SOLEShares3.08M
TypeSH
Market value$444.21M
5.47%
Sole
3.08M
Shared
0.00
None
0.00
PROTAGONIST THERAPEUTICS INC
SOLEShares5.76M
TypeSH
Market value$382.39M
4.71%
Sole
5.76M
Shared
0.00
None
0.00
NATERA INC
SOLEShares2M
TypeSH
Market value$321.94M
3.97%
Sole
2M
Shared
0.00
None
0.00
AKERO THERAPEUTICS INC
SOLEShares5.48M
TypeSH
Market value$260.07M
3.20%
Sole
5.48M
Shared
0.00
None
0.00
UNIQURE NV
SOLEShares4.42M
TypeSH
Market value$258.29M
3.18%
Sole
4.42M
Shared
0.00
None
0.00
PENUMBRA INC
SOLEShares866.50K
TypeSH
Market value$219.50M
2.70%
Sole
866.50K
Shared
0.00
None
0.00
RADNET INC
SOLEShares2.82M
TypeSH
Market value$214.57M
2.64%
Sole
2.82M
Shared
0.00
None
0.00
MERUS N V
SOLEShares2.03M
TypeSH
Market value$190.68M
2.35%
Sole
2.03M
Shared
0.00
None
0.00
TARSUS PHARMACEUTICALS INC
SOLEShares3.18M
TypeSH
Market value$188.84M
2.33%
Sole
3.18M
Shared
0.00
None
0.00
STRYKER CORPORATION
SOLEShares490K
TypeSH
Market value$181.14M
2.23%
Sole
490K
Shared
0.00
None
0.00
IMMUNOCORE HLDGS PLC
SOLEShares4.87M
TypeSH
Market value$176.92M
2.18%
Sole
4.87M
Shared
0.00
None
0.00
ACADIA PHARMACEUTICALS INC
SOLEShares7.14M
TypeSH
Market value$152.46M
1.88%
Sole
7.14M
Shared
0.00
None
0.00
CYTOKINETICS INC
SOLEShares2.72M
TypeSH
Market value$149.55M
1.84%
Sole
2.72M
Shared
0.00
None
0.00
NEUROCRINE BIOSCIENCES INC
SOLEShares1.06M
TypeSH
Market value$149.09M
1.84%
Sole
1.06M
Shared
0.00
None
0.00
AXSOME THERAPEUTICS INC
SOLEShares1.12M
TypeSH
Market value$135.89M
1.67%
Sole
1.12M
Shared
0.00
None
0.00
STOKE THERAPEUTICS INC
SOLEShares5.12M
TypeSH
Market value$120.40M
1.48%
Sole
5.12M
Shared
0.00
None
0.00
APOGEE THERAPEUTICS INC
SOLEShares2.71M
TypeSH
Market value$107.75M
1.33%
Sole
2.71M
Shared
0.00
None
0.00
ESTABLISHMENT LABS HLDGS INC
SOLEShares2.59M
TypeSH
Market value$106.12M
1.31%
Sole
2.59M
Shared
0.00
None
0.00
MASIMO CORP
SOLEShares683.29K
TypeSH
Market value$100.82M
1.24%
Sole
683.29K
Shared
0.00
None
0.00
ULTRAGENYX PHARMACEUTICAL IN
SOLEShares3.26M
TypeSH
Market value$98.01M
1.21%
Sole
3.26M
Shared
0.00
None
0.00
GUARDANT HEALTH INC
SOLEShares1.48M
TypeSH
Market value$92.53M
1.14%
Sole
1.48M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
MADRIGAL PHARMACEUTICALS INCSOLE | COM | 1.99M | SH | $914.42M 11.27% | 1.99M | 0.00 | 0.00 |
ARGENX SESOLE | SPONSORED ADR | 673.50K | SH | $496.74M 6.12% | 673.50K | 0.00 | 0.00 |
AVIDITY BIOSCIENCES INCSOLE | COM | 11.37M | SH | $495.51M 6.11% | 11.37M | 0.00 | 0.00 |
PTC THERAPEUTICS INCSOLE | COM | 7.75M | SH | $475.40M 5.86% | 7.75M | 0.00 | 0.00 |
INSMED INCSOLE | COM PAR $.01 | 3.08M | SH | $444.21M 5.47% | 3.08M | 0.00 | 0.00 |
PROTAGONIST THERAPEUTICS INCSOLE | COM | 5.76M | SH | $382.39M 4.71% | 5.76M | 0.00 | 0.00 |
NATERA INCSOLE | COM | 2M | SH | $321.94M 3.97% | 2M | 0.00 | 0.00 |
AKERO THERAPEUTICS INCSOLE | COM | 5.48M | SH | $260.07M 3.20% | 5.48M | 0.00 | 0.00 |
UNIQURE NVSOLE | SHS | 4.42M | SH | $258.29M 3.18% | 4.42M | 0.00 | 0.00 |
PENUMBRA INCSOLE | COM | 866.50K | SH | $219.50M 2.70% | 866.50K | 0.00 | 0.00 |
RADNET INCSOLE | COM | 2.82M | SH | $214.57M 2.64% | 2.82M | 0.00 | 0.00 |
MERUS N VSOLE | COM | 2.03M | SH | $190.68M 2.35% | 2.03M | 0.00 | 0.00 |
TARSUS PHARMACEUTICALS INCSOLE | COM | 3.18M | SH | $188.84M 2.33% | 3.18M | 0.00 | 0.00 |
STRYKER CORPORATIONSOLE | COM | 490K | SH | $181.14M 2.23% | 490K | 0.00 | 0.00 |
IMMUNOCORE HLDGS PLCSOLE | ADS | 4.87M | SH | $176.92M 2.18% | 4.87M | 0.00 | 0.00 |
ACADIA PHARMACEUTICALS INCSOLE | COM | 7.14M | SH | $152.46M 1.88% | 7.14M | 0.00 | 0.00 |
CYTOKINETICS INCSOLE | COM NEW | 2.72M | SH | $149.55M 1.84% | 2.72M | 0.00 | 0.00 |
NEUROCRINE BIOSCIENCES INCSOLE | COM | 1.06M | SH | $149.09M 1.84% | 1.06M | 0.00 | 0.00 |
AXSOME THERAPEUTICS INCSOLE | COM | 1.12M | SH | $135.89M 1.67% | 1.12M | 0.00 | 0.00 |
STOKE THERAPEUTICS INCSOLE | COM | 5.12M | SH | $120.40M 1.48% | 5.12M | 0.00 | 0.00 |
APOGEE THERAPEUTICS INCSOLE | COM | 2.71M | SH | $107.75M 1.33% | 2.71M | 0.00 | 0.00 |
ESTABLISHMENT LABS HLDGS INCSOLE | COM | 2.59M | SH | $106.12M 1.31% | 2.59M | 0.00 | 0.00 |
MASIMO CORPSOLE | COM | 683.29K | SH | $100.82M 1.24% | 683.29K | 0.00 | 0.00 |
ULTRAGENYX PHARMACEUTICAL INSOLE | COM | 3.26M | SH | $98.01M 1.21% | 3.26M | 0.00 | 0.00 |
GUARDANT HEALTH INCSOLE | COM | 1.48M | SH | $92.53M 1.14% | 1.48M | 0.00 | 0.00 |
Page 1 of 3