Filed: 8/14/2025ACC: 0001493215-25-000007
📋 What this filing means
RTW INVESTMENTS, LP filed this quarterly 13F‑HR report disclosing 73 equity positions with a total reported market value of $7.02B. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
73
Positions
$7.02B
Total AUM (reported)
228.52M
Total Shares
Allocation by class
COM$4.86B69.3%
SPONSORED ADR$371.25M5.3%
SPONSORED ADS$331.77M4.7%
COM PAR $.01$310.43M4.4%
COM NEW$300.21M4.3%
SHS$252.53M3.6%
ADR$193.62M2.8%
Portfolio Concentration
Top 3$1.42B20.2%
4–10$2.09B29.7%
11–25$2.22B31.6%
Rest$1.29B18.4%
Top 3 weight
20.2%
Top 10 weight
50.0%
Voting Authority Distribution
Total shares with voting rights: 228.52M
Sole
Full voting authority
228.52M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole73
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings73
Rows:
MADRIGAL PHARMACEUTICALS INC
SOLEShares1.99M
TypeSH
Market value$603.37M
8.59%
Sole
1.99M
Shared
0.00
None
0.00
NATERA INC
SOLEShares2.59M
TypeSH
Market value$438.17M
6.24%
Sole
2.59M
Shared
0.00
None
0.00
PTC THERAPEUTICS INC
SOLEShares7.75M
TypeSH
Market value$378.33M
5.39%
Sole
7.75M
Shared
0.00
None
0.00
ARGENX SE
SOLEShares673.50K
TypeSH
Market value$371.25M
5.29%
Sole
673.50K
Shared
0.00
None
0.00
PROTAGONIST THERAPEUTICS INC
SOLEShares5.76M
TypeSH
Market value$318.15M
4.53%
Sole
5.76M
Shared
0.00
None
0.00
INSMED INC
SOLEShares3.08M
TypeSH
Market value$310.43M
4.42%
Sole
3.08M
Shared
0.00
None
0.00
AKERO THERAPEUTICS INC
SOLEShares5.48M
TypeSH
Market value$292.28M
4.16%
Sole
5.48M
Shared
0.00
None
0.00
VERONA PHARMA PLC
SOLEShares3.05M
TypeSH
Market value$288.65M
4.11%
Sole
3.05M
Shared
0.00
None
0.00
AVIDITY BIOSCIENCES INC
SOLEShares9.62M
TypeSH
Market value$273.18M
3.89%
Sole
9.62M
Shared
0.00
None
0.00
STRYKER CORPORATION
SOLEShares590.52K
TypeSH
Market value$233.63M
3.33%
Sole
590.52K
Shared
0.00
None
0.00
PENUMBRA INC
SOLEShares863.55K
TypeSH
Market value$221.61M
3.16%
Sole
863.55K
Shared
0.00
None
0.00
MERUS N V
SOLEShares4M
TypeSH
Market value$210.43M
3.00%
Sole
4M
Shared
0.00
None
0.00
ACADIA PHARMACEUTICALS INC
SOLEShares9M
TypeSH
Market value$194.03M
2.76%
Sole
9M
Shared
0.00
None
0.00
ZAI LAB LTD
SOLEShares5.54M
TypeSH
Market value$193.62M
2.76%
Sole
5.54M
Shared
0.00
None
0.00
AXSOME THERAPEUTICS INC
SOLEShares1.52M
TypeSH
Market value$158.35M
2.26%
Sole
1.52M
Shared
0.00
None
0.00
RADNET INC
SOLEShares2.69M
TypeSH
Market value$153.11M
2.18%
Sole
2.69M
Shared
0.00
None
0.00
IMMUNOCORE HLDGS PLC
SOLEShares4.87M
TypeSH
Market value$152.81M
2.18%
Sole
4.87M
Shared
0.00
None
0.00
ALKERMES PLC
SOLEShares4.68M
TypeSH
Market value$133.96M
1.91%
Sole
4.68M
Shared
0.00
None
0.00
NEUROCRINE BIOSCIENCES INC
SOLEShares1.06M
TypeSH
Market value$133.49M
1.90%
Sole
1.06M
Shared
0.00
None
0.00
TARSUS PHARMACEUTICALS INC
SOLEShares3.11M
TypeSH
Market value$126.05M
1.80%
Sole
3.11M
Shared
0.00
None
0.00
APOGEE THERAPEUTICS INC
SOLEShares2.71M
TypeSH
Market value$117.79M
1.68%
Sole
2.71M
Shared
0.00
None
0.00
MASIMO CORP
SOLEShares683.29K
TypeSH
Market value$114.94M
1.64%
Sole
683.29K
Shared
0.00
None
0.00
ESTABLISHMENT LABS HLDGS INC
SOLEShares2.58M
TypeSH
Market value$110.37M
1.57%
Sole
2.58M
Shared
0.00
None
0.00
INTUITIVE SURGICAL INC
SOLEShares202.46K
TypeSH
Market value$110.02M
1.57%
Sole
202.46K
Shared
0.00
None
0.00
CYTOKINETICS INC
SOLEShares2.72M
TypeSH
Market value$89.91M
1.28%
Sole
2.72M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
MADRIGAL PHARMACEUTICALS INCSOLE | COM | 1.99M | SH | $603.37M 8.59% | 1.99M | 0.00 | 0.00 |
NATERA INCSOLE | COM | 2.59M | SH | $438.17M 6.24% | 2.59M | 0.00 | 0.00 |
PTC THERAPEUTICS INCSOLE | COM | 7.75M | SH | $378.33M 5.39% | 7.75M | 0.00 | 0.00 |
ARGENX SESOLE | SPONSORED ADR | 673.50K | SH | $371.25M 5.29% | 673.50K | 0.00 | 0.00 |
PROTAGONIST THERAPEUTICS INCSOLE | COM | 5.76M | SH | $318.15M 4.53% | 5.76M | 0.00 | 0.00 |
INSMED INCSOLE | COM PAR $.01 | 3.08M | SH | $310.43M 4.42% | 3.08M | 0.00 | 0.00 |
AKERO THERAPEUTICS INCSOLE | COM | 5.48M | SH | $292.28M 4.16% | 5.48M | 0.00 | 0.00 |
VERONA PHARMA PLCSOLE | SPONSORED ADS | 3.05M | SH | $288.65M 4.11% | 3.05M | 0.00 | 0.00 |
AVIDITY BIOSCIENCES INCSOLE | COM | 9.62M | SH | $273.18M 3.89% | 9.62M | 0.00 | 0.00 |
STRYKER CORPORATIONSOLE | COM | 590.52K | SH | $233.63M 3.33% | 590.52K | 0.00 | 0.00 |
PENUMBRA INCSOLE | COM | 863.55K | SH | $221.61M 3.16% | 863.55K | 0.00 | 0.00 |
MERUS N VSOLE | COM | 4M | SH | $210.43M 3.00% | 4M | 0.00 | 0.00 |
ACADIA PHARMACEUTICALS INCSOLE | COM | 9M | SH | $194.03M 2.76% | 9M | 0.00 | 0.00 |
ZAI LAB LTDSOLE | ADR | 5.54M | SH | $193.62M 2.76% | 5.54M | 0.00 | 0.00 |
AXSOME THERAPEUTICS INCSOLE | COM | 1.52M | SH | $158.35M 2.26% | 1.52M | 0.00 | 0.00 |
RADNET INCSOLE | COM | 2.69M | SH | $153.11M 2.18% | 2.69M | 0.00 | 0.00 |
IMMUNOCORE HLDGS PLCSOLE | ADS | 4.87M | SH | $152.81M 2.18% | 4.87M | 0.00 | 0.00 |
ALKERMES PLCSOLE | SHS | 4.68M | SH | $133.96M 1.91% | 4.68M | 0.00 | 0.00 |
NEUROCRINE BIOSCIENCES INCSOLE | COM | 1.06M | SH | $133.49M 1.90% | 1.06M | 0.00 | 0.00 |
TARSUS PHARMACEUTICALS INCSOLE | COM | 3.11M | SH | $126.05M 1.80% | 3.11M | 0.00 | 0.00 |
APOGEE THERAPEUTICS INCSOLE | COM | 2.71M | SH | $117.79M 1.68% | 2.71M | 0.00 | 0.00 |
MASIMO CORPSOLE | COM | 683.29K | SH | $114.94M 1.64% | 683.29K | 0.00 | 0.00 |
ESTABLISHMENT LABS HLDGS INCSOLE | COM | 2.58M | SH | $110.37M 1.57% | 2.58M | 0.00 | 0.00 |
INTUITIVE SURGICAL INCSOLE | COM NEW | 202.46K | SH | $110.02M 1.57% | 202.46K | 0.00 | 0.00 |
CYTOKINETICS INCSOLE | COM NEW | 2.72M | SH | $89.91M 1.28% | 2.72M | 0.00 | 0.00 |
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