Filed: 5/15/2026ACC: 0001104659-26-062637
📋 What this filing means
RA CAPITAL MANAGEMENT, L.P. filed this quarterly 13F‑HR report disclosing 85 equity positions with a total reported market value of $9.44B. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
85
Positions
$9.44B
Total AUM (reported)
546.36M
Total Shares
Allocation by class
COMMON STOCK$7.08B75.0%
SPONSORED ADR$2.35B24.9%
W EXP 99/99/999$6.68M0.1%
Portfolio Concentration
Top 3$3.60B38.1%
4–10$2.19B23.2%
11–25$1.98B21.0%
Rest$1.67B17.7%
Top 3 weight
38.1%
Top 10 weight
61.3%
Voting Authority Distribution
Total shares with voting rights: 546.36M
Sole
Full voting authority
546.36M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole85
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings85
Rows:
ASCENDIS PHARMA A/S - ADR
SOLEShares10.28M
TypeSH
Market value$2.35B
24.92%
Sole
10.28M
Shared
0.00
None
0.00
VAXCYTE INC
SOLEShares11.47M
TypeSH
Market value$666.79M
7.07%
Sole
11.47M
Shared
0.00
None
0.00
RHYTHM PHARMACEUTICALS INC
SOLEShares6.67M
TypeSH
Market value$579.81M
6.14%
Sole
6.67M
Shared
0.00
None
0.00
TYRA BIOSCIENCES INC
SOLEShares12.20M
TypeSH
Market value$467.21M
4.95%
Sole
12.20M
Shared
0.00
None
0.00
SIONNA THERAPEUTICS INC
SOLEShares9.91M
TypeSH
Market value$397.09M
4.21%
Sole
9.91M
Shared
0.00
None
0.00
EDGEWISE THERAPEUTICS INC
SOLEShares10.43M
TypeSH
Market value$328.50M
3.48%
Sole
10.43M
Shared
0.00
None
0.00
NEWAMSTERDAM PHARMA CO NV
SOLEShares9.55M
TypeSH
Market value$305.70M
3.24%
Sole
9.55M
Shared
0.00
None
0.00
NUVALENT INC-A
SOLEShares2.53M
TypeSH
Market value$259.62M
2.75%
Sole
2.53M
Shared
0.00
None
0.00
DIANTHUS THERAPEUTICS INC
SOLEShares2.61M
TypeSH
Market value$219.18M
2.32%
Sole
2.61M
Shared
0.00
None
0.00
MINERALYS THERAPEUTICS INC
SOLEShares7.69M
TypeSH
Market value$208.40M
2.21%
Sole
7.69M
Shared
0.00
None
0.00
SPYGLASS PHARMA INC
SOLEShares8.02M
TypeSH
Market value$207.83M
2.20%
Sole
8.02M
Shared
0.00
None
0.00
WAVE LIFE SCIENCES LTD
SOLEShares26.98M
TypeSH
Market value$195.57M
2.07%
Sole
26.98M
Shared
0.00
None
0.00
SEPTERNA INC
SOLEShares7M
TypeSH
Market value$168.11M
1.78%
Sole
7M
Shared
0.00
None
0.00
DISC MEDICINE INC
SOLEShares2.45M
TypeSH
Market value$156.67M
1.66%
Sole
2.45M
Shared
0.00
None
0.00
JANUX THERAPEUTICS INC
SOLEShares11.19M
TypeSH
Market value$155.54M
1.65%
Sole
11.19M
Shared
0.00
None
0.00
BIOCRYST PHARMACEUTICALS INC
SOLEShares15.83M
TypeSH
Market value$150.67M
1.60%
Sole
15.83M
Shared
0.00
None
0.00
BICARA THERAPEUTICS INC
SOLEShares7.26M
TypeSH
Market value$144.32M
1.53%
Sole
7.26M
Shared
0.00
None
0.00
PRAXIS PRECISION MEDICINES I
SOLEShares373.79K
TypeSH
Market value$120.43M
1.28%
Sole
373.79K
Shared
0.00
None
0.00
GH RESEARCH PLC
SOLEShares7.68M
TypeSH
Market value$107.93M
1.14%
Sole
7.68M
Shared
0.00
None
0.00
ZAI LAB LTD-ADR
SOLEShares5.71M
TypeSH
Market value$107.35M
1.14%
Sole
5.71M
Shared
0.00
None
0.00
TAYSHA GENE THERAPIES INC
SOLEShares23.56M
TypeSH
Market value$105.29M
1.12%
Sole
23.56M
Shared
0.00
None
0.00
VOR BIOPHARMA INC
SOLEShares5.40M
TypeSH
Market value$96.43M
1.02%
Sole
5.40M
Shared
0.00
None
0.00
GERON CORP
SOLEShares63.77M
TypeSH
Market value$95.02M
1.01%
Sole
63.77M
Shared
0.00
None
0.00
ARS PHARMACEUTICALS INC
SOLEShares10.86M
TypeSH
Market value$87.21M
0.92%
Sole
10.86M
Shared
0.00
None
0.00
SAREPTA THERAPEUTICS INC
SOLEShares3.90M
TypeSH
Market value$84.92M
0.90%
Sole
3.90M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
ASCENDIS PHARMA A/S - ADRSOLE | SPONSORED ADR | 10.28M | SH | $2.35B 24.92% | 10.28M | 0.00 | 0.00 |
VAXCYTE INCSOLE | COMMON STOCK | 11.47M | SH | $666.79M 7.07% | 11.47M | 0.00 | 0.00 |
RHYTHM PHARMACEUTICALS INCSOLE | COMMON STOCK | 6.67M | SH | $579.81M 6.14% | 6.67M | 0.00 | 0.00 |
TYRA BIOSCIENCES INCSOLE | COMMON STOCK | 12.20M | SH | $467.21M 4.95% | 12.20M | 0.00 | 0.00 |
SIONNA THERAPEUTICS INCSOLE | COMMON STOCK | 9.91M | SH | $397.09M 4.21% | 9.91M | 0.00 | 0.00 |
EDGEWISE THERAPEUTICS INCSOLE | COMMON STOCK | 10.43M | SH | $328.50M 3.48% | 10.43M | 0.00 | 0.00 |
NEWAMSTERDAM PHARMA CO NVSOLE | COMMON STOCK | 9.55M | SH | $305.70M 3.24% | 9.55M | 0.00 | 0.00 |
NUVALENT INC-ASOLE | COMMON STOCK | 2.53M | SH | $259.62M 2.75% | 2.53M | 0.00 | 0.00 |
DIANTHUS THERAPEUTICS INCSOLE | COMMON STOCK | 2.61M | SH | $219.18M 2.32% | 2.61M | 0.00 | 0.00 |
MINERALYS THERAPEUTICS INCSOLE | COMMON STOCK | 7.69M | SH | $208.40M 2.21% | 7.69M | 0.00 | 0.00 |
SPYGLASS PHARMA INCSOLE | COMMON STOCK | 8.02M | SH | $207.83M 2.20% | 8.02M | 0.00 | 0.00 |
WAVE LIFE SCIENCES LTDSOLE | COMMON STOCK | 26.98M | SH | $195.57M 2.07% | 26.98M | 0.00 | 0.00 |
SEPTERNA INCSOLE | COMMON STOCK | 7M | SH | $168.11M 1.78% | 7M | 0.00 | 0.00 |
DISC MEDICINE INCSOLE | COMMON STOCK | 2.45M | SH | $156.67M 1.66% | 2.45M | 0.00 | 0.00 |
JANUX THERAPEUTICS INCSOLE | COMMON STOCK | 11.19M | SH | $155.54M 1.65% | 11.19M | 0.00 | 0.00 |
BIOCRYST PHARMACEUTICALS INCSOLE | COMMON STOCK | 15.83M | SH | $150.67M 1.60% | 15.83M | 0.00 | 0.00 |
BICARA THERAPEUTICS INCSOLE | COMMON STOCK | 7.26M | SH | $144.32M 1.53% | 7.26M | 0.00 | 0.00 |
PRAXIS PRECISION MEDICINES ISOLE | COMMON STOCK | 373.79K | SH | $120.43M 1.28% | 373.79K | 0.00 | 0.00 |
GH RESEARCH PLCSOLE | COMMON STOCK | 7.68M | SH | $107.93M 1.14% | 7.68M | 0.00 | 0.00 |
ZAI LAB LTD-ADRSOLE | COMMON STOCK | 5.71M | SH | $107.35M 1.14% | 5.71M | 0.00 | 0.00 |
TAYSHA GENE THERAPIES INCSOLE | COMMON STOCK | 23.56M | SH | $105.29M 1.12% | 23.56M | 0.00 | 0.00 |
VOR BIOPHARMA INCSOLE | COMMON STOCK | 5.40M | SH | $96.43M 1.02% | 5.40M | 0.00 | 0.00 |
GERON CORPSOLE | COMMON STOCK | 63.77M | SH | $95.02M 1.01% | 63.77M | 0.00 | 0.00 |
ARS PHARMACEUTICALS INCSOLE | COMMON STOCK | 10.86M | SH | $87.21M 0.92% | 10.86M | 0.00 | 0.00 |
SAREPTA THERAPEUTICS INCSOLE | COMMON STOCK | 3.90M | SH | $84.92M 0.90% | 3.90M | 0.00 | 0.00 |
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