Filed: 2/17/2026ACC: 0001104659-26-016482
📋 What this filing means
RA CAPITAL MANAGEMENT, L.P. filed this quarterly 13F‑HR report disclosing 71 equity positions with a total reported market value of $9.76B. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
71
Positions
$9.76B
Total AUM (reported)
468.02M
Total Shares
Allocation by class
SH$9.76B100.0%
Portfolio Concentration
Top 3$3.65B37.4%
4–10$2.76B28.2%
11–25$2.03B20.8%
Rest$1.32B13.5%
Top 3 weight
37.4%
Top 10 weight
65.6%
Voting Authority Distribution
Total shares with voting rights: 468.02M
Sole
Full voting authority
468.02M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole71
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings71
Rows:
ASCENDIS PHARMA A/S - ADR
SOLEShares10.28M
TypeSH
Market value$2.19B
22.46%
Sole
10.28M
Shared
0.00
None
0.00
CIDARA THERAPEUTICS INC
SOLEShares3.37M
TypeSH
Market value$743.41M
7.62%
Sole
3.37M
Shared
0.00
None
0.00
RHYTHM PHARMACEUTICALS INC
SOLEShares6.67M
TypeSH
Market value$713.62M
7.31%
Sole
6.67M
Shared
0.00
None
0.00
AVIDITY BIOSCIENCES INC
SOLEShares8.64M
TypeSH
Market value$623.28M
6.39%
Sole
8.64M
Shared
0.00
None
0.00
VAXCYTE INC
SOLEShares10.72M
TypeSH
Market value$494.83M
5.07%
Sole
10.72M
Shared
0.00
None
0.00
SIONNA THERAPEUTICS INC
SOLEShares9.91M
TypeSH
Market value$407.49M
4.17%
Sole
9.91M
Shared
0.00
None
0.00
NEWAMSTERDAM PHARMA CO NV
SOLEShares9.55M
TypeSH
Market value$335.02M
3.43%
Sole
9.55M
Shared
0.00
None
0.00
TYRA BIOSCIENCES INC
SOLEShares12.20M
TypeSH
Market value$320.70M
3.29%
Sole
12.20M
Shared
0.00
None
0.00
WAVE LIFE SCIENCES LTD
SOLEShares18.20M
TypeSH
Market value$309.45M
3.17%
Sole
18.20M
Shared
0.00
None
0.00
MINERALYS THERAPEUTICS INC
SOLEShares7.32M
TypeSH
Market value$265.78M
2.72%
Sole
7.32M
Shared
0.00
None
0.00
EDGEWISE THERAPEUTICS INC
SOLEShares10.43M
TypeSH
Market value$258.78M
2.65%
Sole
10.43M
Shared
0.00
None
0.00
SEPTERNA INC
SOLEShares7M
TypeSH
Market value$195.04M
2.00%
Sole
7M
Shared
0.00
None
0.00
NUVALENT INC-A
SOLEShares1.88M
TypeSH
Market value$189.11M
1.94%
Sole
1.88M
Shared
0.00
None
0.00
DISC MEDICINE INC
SOLEShares1.98M
TypeSH
Market value$156.92M
1.61%
Sole
1.98M
Shared
0.00
None
0.00
JANUX THERAPEUTICS INC
SOLEShares11.19M
TypeSH
Market value$154.42M
1.58%
Sole
11.19M
Shared
0.00
None
0.00
PEPGEN INC
SOLEShares20.06M
TypeSH
Market value$130.62M
1.34%
Sole
20.06M
Shared
0.00
None
0.00
TAYSHA GENE THERAPIES INC
SOLEShares23.56M
TypeSH
Market value$129.56M
1.33%
Sole
23.56M
Shared
0.00
None
0.00
ARS PHARMACEUTICALS INC
SOLEShares10.86M
TypeSH
Market value$126.53M
1.30%
Sole
10.86M
Shared
0.00
None
0.00
BIOCRYST PHARMACEUTICALS INC
SOLEShares15.83M
TypeSH
Market value$123.45M
1.26%
Sole
15.83M
Shared
0.00
None
0.00
BICARA THERAPEUTICS INC
SOLEShares6.96M
TypeSH
Market value$117.07M
1.20%
Sole
6.96M
Shared
0.00
None
0.00
PRAXIS PRECISION MEDICINES I
SOLEShares373.79K
TypeSH
Market value$110.17M
1.13%
Sole
373.79K
Shared
0.00
None
0.00
GH RESEARCH PLC
SOLEShares7.68M
TypeSH
Market value$97.49M
1.00%
Sole
7.68M
Shared
0.00
None
0.00
GERON CORP
SOLEShares63.77M
TypeSH
Market value$84.18M
0.86%
Sole
63.77M
Shared
0.00
None
0.00
ARCELLX INC
SOLEShares1.27M
TypeSH
Market value$82.62M
0.85%
Sole
1.27M
Shared
0.00
None
0.00
CLIMB BIO INC
SOLEShares11.29M
TypeSH
Market value$77.71M
0.80%
Sole
11.29M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
ASCENDIS PHARMA A/S - ADRSOLE | SH | 10.28M | SH | $2.19B 22.46% | 10.28M | 0.00 | 0.00 |
CIDARA THERAPEUTICS INCSOLE | SH | 3.37M | SH | $743.41M 7.62% | 3.37M | 0.00 | 0.00 |
RHYTHM PHARMACEUTICALS INCSOLE | SH | 6.67M | SH | $713.62M 7.31% | 6.67M | 0.00 | 0.00 |
AVIDITY BIOSCIENCES INCSOLE | SH | 8.64M | SH | $623.28M 6.39% | 8.64M | 0.00 | 0.00 |
VAXCYTE INCSOLE | SH | 10.72M | SH | $494.83M 5.07% | 10.72M | 0.00 | 0.00 |
SIONNA THERAPEUTICS INCSOLE | SH | 9.91M | SH | $407.49M 4.17% | 9.91M | 0.00 | 0.00 |
NEWAMSTERDAM PHARMA CO NVSOLE | SH | 9.55M | SH | $335.02M 3.43% | 9.55M | 0.00 | 0.00 |
TYRA BIOSCIENCES INCSOLE | SH | 12.20M | SH | $320.70M 3.29% | 12.20M | 0.00 | 0.00 |
WAVE LIFE SCIENCES LTDSOLE | SH | 18.20M | SH | $309.45M 3.17% | 18.20M | 0.00 | 0.00 |
MINERALYS THERAPEUTICS INCSOLE | SH | 7.32M | SH | $265.78M 2.72% | 7.32M | 0.00 | 0.00 |
EDGEWISE THERAPEUTICS INCSOLE | SH | 10.43M | SH | $258.78M 2.65% | 10.43M | 0.00 | 0.00 |
SEPTERNA INCSOLE | SH | 7M | SH | $195.04M 2.00% | 7M | 0.00 | 0.00 |
NUVALENT INC-ASOLE | SH | 1.88M | SH | $189.11M 1.94% | 1.88M | 0.00 | 0.00 |
DISC MEDICINE INCSOLE | SH | 1.98M | SH | $156.92M 1.61% | 1.98M | 0.00 | 0.00 |
JANUX THERAPEUTICS INCSOLE | SH | 11.19M | SH | $154.42M 1.58% | 11.19M | 0.00 | 0.00 |
PEPGEN INCSOLE | SH | 20.06M | SH | $130.62M 1.34% | 20.06M | 0.00 | 0.00 |
TAYSHA GENE THERAPIES INCSOLE | SH | 23.56M | SH | $129.56M 1.33% | 23.56M | 0.00 | 0.00 |
ARS PHARMACEUTICALS INCSOLE | SH | 10.86M | SH | $126.53M 1.30% | 10.86M | 0.00 | 0.00 |
BIOCRYST PHARMACEUTICALS INCSOLE | SH | 15.83M | SH | $123.45M 1.26% | 15.83M | 0.00 | 0.00 |
BICARA THERAPEUTICS INCSOLE | SH | 6.96M | SH | $117.07M 1.20% | 6.96M | 0.00 | 0.00 |
PRAXIS PRECISION MEDICINES ISOLE | SH | 373.79K | SH | $110.17M 1.13% | 373.79K | 0.00 | 0.00 |
GH RESEARCH PLCSOLE | SH | 7.68M | SH | $97.49M 1.00% | 7.68M | 0.00 | 0.00 |
GERON CORPSOLE | SH | 63.77M | SH | $84.18M 0.86% | 63.77M | 0.00 | 0.00 |
ARCELLX INCSOLE | SH | 1.27M | SH | $82.62M 0.85% | 1.27M | 0.00 | 0.00 |
CLIMB BIO INCSOLE | SH | 11.29M | SH | $77.71M 0.80% | 11.29M | 0.00 | 0.00 |
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