Filed: 11/14/2025ACC: 0001104659-25-112469
📋 What this filing means
RA CAPITAL MANAGEMENT, L.P. filed this quarterly 13F‑HR report disclosing 67 equity positions with a total reported market value of $8.12B. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
67
Positions
$8.12B
Total AUM (reported)
459.07M
Total Shares
Allocation by class
SH$8.12B100.0%
Portfolio Concentration
Top 3$3.05B37.6%
4–10$2.14B26.3%
11–25$1.99B24.5%
Rest$943.25M11.6%
Top 3 weight
37.6%
Top 10 weight
63.9%
Voting Authority Distribution
Total shares with voting rights: 459.07M
Sole
Full voting authority
459.07M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole67
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings67
Rows:
ASCENDIS PHARMA A/S - ADR
SOLEShares10.28M
TypeSH
Market value$2.04B
25.19%
Sole
10.28M
Shared
0.00
None
0.00
RHYTHM PHARMACEUTICALS INC
SOLEShares5.68M
TypeSH
Market value$573.76M
7.07%
Sole
5.68M
Shared
0.00
None
0.00
VAXCYTE INC
SOLEShares11.97M
TypeSH
Market value$431.01M
5.31%
Sole
11.97M
Shared
0.00
None
0.00
AVIDITY BIOSCIENCES INC
SOLEShares8.64M
TypeSH
Market value$376.49M
4.64%
Sole
8.64M
Shared
0.00
None
0.00
CIDARA THERAPEUTICS INC
SOLEShares3.37M
TypeSH
Market value$322.28M
3.97%
Sole
3.37M
Shared
0.00
None
0.00
SIONNA THERAPEUTICS INC
SOLEShares10.45M
TypeSH
Market value$307.20M
3.79%
Sole
10.45M
Shared
0.00
None
0.00
89BIO INC
SOLEShares19.89M
TypeSH
Market value$292.38M
3.60%
Sole
19.89M
Shared
0.00
None
0.00
NEWAMSTERDAM PHARMA CO NV
SOLEShares10.14M
TypeSH
Market value$288.35M
3.55%
Sole
10.14M
Shared
0.00
None
0.00
MINERALYS THERAPEUTICS INC
SOLEShares7.32M
TypeSH
Market value$277.72M
3.42%
Sole
7.32M
Shared
0.00
None
0.00
JANUX THERAPEUTICS INC
SOLEShares11.19M
TypeSH
Market value$273.48M
3.37%
Sole
11.19M
Shared
0.00
None
0.00
ARCELLX INC
SOLEShares3.04M
TypeSH
Market value$249.30M
3.07%
Sole
3.04M
Shared
0.00
None
0.00
LENZ THERAPEUTICS INC
SOLEShares4.18M
TypeSH
Market value$194.65M
2.40%
Sole
4.18M
Shared
0.00
None
0.00
TYRA BIOSCIENCES INC
SOLEShares12.20M
TypeSH
Market value$170.66M
2.10%
Sole
12.20M
Shared
0.00
None
0.00
EDGEWISE THERAPEUTICS INC
SOLEShares10.43M
TypeSH
Market value$169.15M
2.08%
Sole
10.43M
Shared
0.00
None
0.00
WAVE LIFE SCIENCES LTD
SOLEShares18.20M
TypeSH
Market value$133.24M
1.64%
Sole
18.20M
Shared
0.00
None
0.00
SEPTERNA INC
SOLEShares7M
TypeSH
Market value$131.59M
1.62%
Sole
7M
Shared
0.00
None
0.00
DIANTHUS THERAPEUTICS INC
SOLEShares2.87M
TypeSH
Market value$112.81M
1.39%
Sole
2.87M
Shared
0.00
None
0.00
BICARA THERAPEUTICS INC
SOLEShares6.96M
TypeSH
Market value$109.84M
1.35%
Sole
6.96M
Shared
0.00
None
0.00
GH RESEARCH PLC
SOLEShares7.68M
TypeSH
Market value$109.78M
1.35%
Sole
7.68M
Shared
0.00
None
0.00
ARS PHARMACEUTICALS INC
SOLEShares10.86M
TypeSH
Market value$109.15M
1.34%
Sole
10.86M
Shared
0.00
None
0.00
NUVALENT INC-A
SOLEShares1.25M
TypeSH
Market value$107.79M
1.33%
Sole
1.25M
Shared
0.00
None
0.00
DISC MEDICINE INC
SOLEShares1.58M
TypeSH
Market value$104.22M
1.28%
Sole
1.58M
Shared
0.00
None
0.00
VOR BIOPHARMA INC
SOLEShares1.98M
TypeSH
Market value$96.58M
1.19%
Sole
1.98M
Shared
0.00
None
0.00
FULCRUM THERAPEUTICS INC
SOLEShares10.23M
TypeSH
Market value$94.11M
1.16%
Sole
10.23M
Shared
0.00
None
0.00
PEPGEN INC
SOLEShares20.06M
TypeSH
Market value$92.70M
1.14%
Sole
20.06M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
ASCENDIS PHARMA A/S - ADRSOLE | SH | 10.28M | SH | $2.04B 25.19% | 10.28M | 0.00 | 0.00 |
RHYTHM PHARMACEUTICALS INCSOLE | SH | 5.68M | SH | $573.76M 7.07% | 5.68M | 0.00 | 0.00 |
VAXCYTE INCSOLE | SH | 11.97M | SH | $431.01M 5.31% | 11.97M | 0.00 | 0.00 |
AVIDITY BIOSCIENCES INCSOLE | SH | 8.64M | SH | $376.49M 4.64% | 8.64M | 0.00 | 0.00 |
CIDARA THERAPEUTICS INCSOLE | SH | 3.37M | SH | $322.28M 3.97% | 3.37M | 0.00 | 0.00 |
SIONNA THERAPEUTICS INCSOLE | SH | 10.45M | SH | $307.20M 3.79% | 10.45M | 0.00 | 0.00 |
89BIO INCSOLE | SH | 19.89M | SH | $292.38M 3.60% | 19.89M | 0.00 | 0.00 |
NEWAMSTERDAM PHARMA CO NVSOLE | SH | 10.14M | SH | $288.35M 3.55% | 10.14M | 0.00 | 0.00 |
MINERALYS THERAPEUTICS INCSOLE | SH | 7.32M | SH | $277.72M 3.42% | 7.32M | 0.00 | 0.00 |
JANUX THERAPEUTICS INCSOLE | SH | 11.19M | SH | $273.48M 3.37% | 11.19M | 0.00 | 0.00 |
ARCELLX INCSOLE | SH | 3.04M | SH | $249.30M 3.07% | 3.04M | 0.00 | 0.00 |
LENZ THERAPEUTICS INCSOLE | SH | 4.18M | SH | $194.65M 2.40% | 4.18M | 0.00 | 0.00 |
TYRA BIOSCIENCES INCSOLE | SH | 12.20M | SH | $170.66M 2.10% | 12.20M | 0.00 | 0.00 |
EDGEWISE THERAPEUTICS INCSOLE | SH | 10.43M | SH | $169.15M 2.08% | 10.43M | 0.00 | 0.00 |
WAVE LIFE SCIENCES LTDSOLE | SH | 18.20M | SH | $133.24M 1.64% | 18.20M | 0.00 | 0.00 |
SEPTERNA INCSOLE | SH | 7M | SH | $131.59M 1.62% | 7M | 0.00 | 0.00 |
DIANTHUS THERAPEUTICS INCSOLE | SH | 2.87M | SH | $112.81M 1.39% | 2.87M | 0.00 | 0.00 |
BICARA THERAPEUTICS INCSOLE | SH | 6.96M | SH | $109.84M 1.35% | 6.96M | 0.00 | 0.00 |
GH RESEARCH PLCSOLE | SH | 7.68M | SH | $109.78M 1.35% | 7.68M | 0.00 | 0.00 |
ARS PHARMACEUTICALS INCSOLE | SH | 10.86M | SH | $109.15M 1.34% | 10.86M | 0.00 | 0.00 |
NUVALENT INC-ASOLE | SH | 1.25M | SH | $107.79M 1.33% | 1.25M | 0.00 | 0.00 |
DISC MEDICINE INCSOLE | SH | 1.58M | SH | $104.22M 1.28% | 1.58M | 0.00 | 0.00 |
VOR BIOPHARMA INCSOLE | SH | 1.98M | SH | $96.58M 1.19% | 1.98M | 0.00 | 0.00 |
FULCRUM THERAPEUTICS INCSOLE | SH | 10.23M | SH | $94.11M 1.16% | 10.23M | 0.00 | 0.00 |
PEPGEN INCSOLE | SH | 20.06M | SH | $92.70M 1.14% | 20.06M | 0.00 | 0.00 |
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