PROPEL BIO MANAGEMENT, LLC

Filed: 8/13/2026ACC: 0001829126-26-008753

📋 What this filing means

PROPEL BIO MANAGEMENT, LLC filed this quarterly 13F‑HR report disclosing 29 equity positions with a total reported market value of $191.09M. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.

Positions

$191.09M

Total AUM (reported)

29.28M

Total Shares

Allocation by class

COMM$180.87M94.7%

ADRS$10.21M5.3%

Portfolio Concentration

Top 3$69.09M36.2%

4–10$61.13M32.0%

11–25$56.16M29.4%

Rest$4.70M2.5%

Top 3 weight

36.2%

Top 10 weight

68.1%

Voting Authority Distribution

Total shares with voting rights: 29.28M

Sole

Full voting authority

20M

% of voting shares68.3%

Shared

Joint voting authority

9.29M

% of voting shares31.7%

None

No voting authority

0.00

% of voting shares0.0%

Investment Discretion (by position count)

Sole0

Shared0

Other29

Dominant voting typeSole · 68.3% of voting shares

Institutional Holdings29

Rows:

PLAINS GP HOLDINGS LP-CL

DFND

COMM

Shares1.27M

TypeSH

Market value$30.88M

16.16%

Sole

0.00

Shared

1.27M

None

0.00

ACHIEVE LIFE SCIENCES INC

DFND

COMM

Shares4.03M

TypeSH

Market value$26.34M

13.79%

Sole

2.60M

Shared

1.43M

None

0.00

CORCEPT THERAPEUTICS INC

DFND

COMM

Shares136.50K

TypeSH

Market value$11.87M

6.21%

Sole

110.06K

Shared

26.43K

None

0.00

PHATHOM PHARMACEUTICALS I

DFND

COMM

Shares1.05M

TypeSH

Market value$11.40M

5.96%

Sole

801.09K

Shared

249.27K

None

0.00

DELCATH SYSTEMS INC

DFND

COMM

Shares871.46K

TypeSH

Market value$10.97M

5.74%

Sole

610.33K

Shared

261.13K

None

0.00

MILESTONE PHARMACEUTICALS

DFND

COMM

Shares7.43M

TypeSH

Market value$9.96M

5.21%

Sole

4.08M

Shared

3.35M

None

0.00

COMPASS PATHWAYS PLC

DFND

ADRS

Shares573.09K

TypeSH

Market value$8.11M

4.24%

Sole

458.81K

Shared

114.28K

None

0.00

KYVERNA THERAPEUTICS INC

DFND

COMM

Shares883.20K

TypeSH

Market value$7.87M

4.12%

Sole

700.60K

Shared

182.60K

None

0.00

ARTIVA BIOTHERAPEUTICS IN

DFND

COMM

Shares696.44K

TypeSH

Market value$6.76M

3.54%

Sole

595.08K

Shared

101.36K

None

0.00

ABEONA THERAPEUTICS INC

DFND

COMM

Shares983.07K

TypeSH

Market value$6.08M

3.18%

Sole

637.65K

Shared

345.42K

None

0.00

AQUESTIVE THERAPEUTICS IN

DFND

COMM

Shares1.44M

TypeSH

Market value$6.00M

3.14%

Sole

1.16M

Shared

278.72K

None

0.00

PALISADE BIO INC

DFND

COMM

Shares2.58M

TypeSH

Market value$5.40M

2.82%

Sole

2.13M

Shared

450.54K

None

0.00

IMMUNIC INC

DFND

COMM

Shares325.02K

TypeSH

Market value$5.00M

2.61%

Sole

294.30K

Shared

30.73K

None

0.00

INVENTIVA SA - ADR

DFND

COMM

Shares1.28M

TypeSH

Market value$4.84M

2.53%

Sole

967.73K

Shared

313.48K

None

0.00

SAB BIOTHERAPEUTICS INC

DFND

COMM

Shares1.08M

TypeSH

Market value$4.20M

2.20%

Sole

971.73K

Shared

104.85K

None

0.00

ORCHESTRA BIOMED HOLDINGS

DFND

COMM

Shares896.70K

TypeSH

Market value$3.87M

2.02%

Sole

677.31K

Shared

219.39K

None

0.00

CELLDEX THERAPEUTICS INC

DFND

COMM

Shares103.69K

TypeSH

Market value$3.86M

2.02%

Sole

50.56K

Shared

53.13K

None

0.00

ZEVRA THERAPEUTICS INC

DFND

COMM

Shares253.54K

TypeSH

Market value$3.64M

1.90%

Sole

186.17K

Shared

67.37K

None

0.00

OCULAR THERAPEUTIX INC

DFND

COMM

Shares357.97K

TypeSH

Market value$3.52M

1.84%

Sole

276.92K

Shared

81.05K

None

0.00

4D MOLECULAR THERAPEUTICS IN

DFND

COMM

Shares252.65K

TypeSH

Market value$3.36M

1.76%

Sole

252.65K

Shared

0.00

None

0.00

OVID THERAPEUTICS INC

DFND

COMM

Shares1.12M

TypeSH

Market value$3.00M

1.57%

Sole

1.02M

Shared

96.82K

None

0.00

EYEPOINT INC

DFND

COMM

Shares191.75K

TypeSH

Market value$2.74M

1.43%

Sole

146.34K

Shared

45.41K

None

0.00

UPSTREAM BIO INC

DFND

COMM

Shares350.39K

TypeSH

Market value$2.42M

1.27%

Sole

288.28K

Shared

62.11K

None

0.00

SCYNEXIS INC

DFND

COMM

Shares543.48K

TypeSH

Market value$2.21M

1.16%

Sole

543.48K

Shared

0.00

None

0.00

SILENCE THERAPEUTICS PLC

DFND

ADRS

Shares191.73K

TypeSH

Market value$2.11M

1.10%

Sole

191.73K

Shared

0.00

None

0.00

Issuer	Class	Shares	Type	Value / Portfolio %	Voting — Sole	Shared
PLAINS GP HOLDINGS LP-CLDFND	COMM	1.27M	SH	$30.88M 16.16%	0.00	1.27M
ACHIEVE LIFE SCIENCES INCDFND	COMM	4.03M	SH	$26.34M 13.79%	2.60M	1.43M
CORCEPT THERAPEUTICS INCDFND	COMM	136.50K	SH	$11.87M 6.21%	110.06K	26.43K
PHATHOM PHARMACEUTICALS IDFND	COMM	1.05M	SH	$11.40M 5.96%	801.09K	249.27K
DELCATH SYSTEMS INCDFND	COMM	871.46K	SH	$10.97M 5.74%	610.33K	261.13K
MILESTONE PHARMACEUTICALSDFND	COMM	7.43M	SH	$9.96M 5.21%	4.08M	3.35M
COMPASS PATHWAYS PLCDFND	ADRS	573.09K	SH	$8.11M 4.24%	458.81K	114.28K
KYVERNA THERAPEUTICS INCDFND	COMM	883.20K	SH	$7.87M 4.12%	700.60K	182.60K
ARTIVA BIOTHERAPEUTICS INDFND	COMM	696.44K	SH	$6.76M 3.54%	595.08K	101.36K
ABEONA THERAPEUTICS INCDFND	COMM	983.07K	SH	$6.08M 3.18%	637.65K	345.42K
AQUESTIVE THERAPEUTICS INDFND	COMM	1.44M	SH	$6.00M 3.14%	1.16M	278.72K
PALISADE BIO INCDFND	COMM	2.58M	SH	$5.40M 2.82%	2.13M	450.54K
IMMUNIC INCDFND	COMM	325.02K	SH	$5.00M 2.61%	294.30K	30.73K
INVENTIVA SA - ADRDFND	COMM	1.28M	SH	$4.84M 2.53%	967.73K	313.48K
SAB BIOTHERAPEUTICS INCDFND	COMM	1.08M	SH	$4.20M 2.20%	971.73K	104.85K
ORCHESTRA BIOMED HOLDINGSDFND	COMM	896.70K	SH	$3.87M 2.02%	677.31K	219.39K
CELLDEX THERAPEUTICS INCDFND	COMM	103.69K	SH	$3.86M 2.02%	50.56K	53.13K
ZEVRA THERAPEUTICS INCDFND	COMM	253.54K	SH	$3.64M 1.90%	186.17K	67.37K
OCULAR THERAPEUTIX INCDFND	COMM	357.97K	SH	$3.52M 1.84%	276.92K	81.05K
4D MOLECULAR THERAPEUTICS INDFND	COMM	252.65K	SH	$3.36M 1.76%	252.65K	0.00
OVID THERAPEUTICS INCDFND	COMM	1.12M	SH	$3.00M 1.57%	1.02M	96.82K
EYEPOINT INCDFND	COMM	191.75K	SH	$2.74M 1.43%	146.34K	45.41K
UPSTREAM BIO INCDFND	COMM	350.39K	SH	$2.42M 1.27%	288.28K	62.11K
SCYNEXIS INCDFND	COMM	543.48K	SH	$2.21M 1.16%	543.48K	0.00
SILENCE THERAPEUTICS PLCDFND	ADRS	191.73K	SH	$2.11M 1.10%	191.73K	0.00

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