Filed: 2/17/2026ACC: 0001012975-26-000155
📋 What this filing means
PERCEPTIVE ADVISORS LLC filed this quarterly 13F‑HR report disclosing 116 equity positions with a total reported market value of $5.61B. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
116
Positions
$5.61B
Total AUM (reported)
264.09M
Total Shares
Allocation by class
COM$3.58B63.9%
COM NEW$963.39M17.2%
SHS$292.10M5.2%
SPONSORED ADR$230.60M4.1%
SPONSORED ADS$201.04M3.6%
STATE STREET SPD$134.12M2.4%
COMMON STOCK$95.59M1.7%
Portfolio Concentration
Top 3$1.18B21.0%
4–10$1.17B20.8%
11–25$1.43B25.5%
Rest$1.84B32.7%
Top 3 weight
21.0%
Top 10 weight
41.8%
Voting Authority Distribution
Total shares with voting rights: 264.09M
Sole
Full voting authority
264.09M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole116
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings116
Rows:
PRAXIS PRECISION MEDICINES I
SOLEShares2M
TypeSH
Market value$588.30M
10.49%
Sole
2M
Shared
0.00
None
0.00
CELCUITY INC
SOLEShares3.16M
TypeSH
Market value$315.20M
5.62%
Sole
3.16M
Shared
0.00
None
0.00
RHYTHM PHARMACEUTICALS INC
SOLEShares2.55M
TypeSH
Market value$272.57M
4.86%
Sole
2.55M
Shared
0.00
None
0.00
ASCENDIS PHARMA A/S
SOLEShares1.08M
TypeSH
Market value$230.60M
4.11%
Sole
1.08M
Shared
0.00
None
0.00
APOGEE THERAPEUTICS INC
SOLEShares2.33M
TypeSH
Market value$175.92M
3.14%
Sole
2.33M
Shared
0.00
None
0.00
ROIVANT SCIENCES LTD
SOLEShares7.99M
TypeSH
Market value$173.28M
3.09%
Sole
7.99M
Shared
0.00
None
0.00
NUVALENT INC
SOLEShares1.67M
TypeSH
Market value$167.49M
2.99%
Sole
1.67M
Shared
0.00
None
0.00
TRAVERE THERAPEUTICS INC
SOLEShares4.28M
TypeSH
Market value$163.47M
2.91%
Sole
4.28M
Shared
0.00
None
0.00
SPDR SERIES TRUST
SOLEShares1.10M
TypeSH
Market value$134.12M
2.39%
Sole
1.10M
Shared
0.00
None
0.00
EXACT SCIENCES CORP
SOLEShares1.20M
TypeSH
Market value$121.92M
2.17%
Sole
1.20M
Shared
0.00
None
0.00
PROTAGONIST THERAPEUTICS INC
SOLEShares1.35M
TypeSH
Market value$117.95M
2.10%
Sole
1.35M
Shared
0.00
None
0.00
INHIBRX BIOSCIENCES INC
SOLEShares1.45M
TypeSH
Market value$114.76M
2.05%
Sole
1.45M
Shared
0.00
None
0.00
EDGEWISE THERAPEUTICS
SOLEShares4.46M
TypeSH
Market value$110.62M
1.97%
Sole
4.46M
Shared
0.00
None
0.00
IMMATICS N.V
SOLEShares10.38M
TypeSH
Market value$109.03M
1.94%
Sole
10.38M
Shared
0.00
None
0.00
SPYRE THERAPEUTICS INC
SOLEShares3.07M
TypeSH
Market value$100.55M
1.79%
Sole
3.07M
Shared
0.00
None
0.00
AMYLYX PHARMACEUTICALS INC
SOLEShares8.28M
TypeSH
Market value$100.08M
1.78%
Sole
8.28M
Shared
0.00
None
0.00
ARCELLX INC
SOLEShares1.47M
TypeSH
Market value$95.59M
1.70%
Sole
1.47M
Shared
0.00
None
0.00
VIRIDIAN THERAPEUTICS INC
SOLEShares3.04M
TypeSH
Market value$94.69M
1.69%
Sole
3.04M
Shared
0.00
None
0.00
BOSTON SCIENTIFIC CORP
SOLEShares979K
TypeSH
Market value$93.35M
1.66%
Sole
979K
Shared
0.00
None
0.00
AMICUS THERAPEUTICS INC
SOLEShares6.37M
TypeSH
Market value$90.72M
1.62%
Sole
6.37M
Shared
0.00
None
0.00
ZYMEWORKS INC
SOLEShares3.26M
TypeSH
Market value$85.88M
1.53%
Sole
3.26M
Shared
0.00
None
0.00
ASTRIA THERAPEUTICS INC
SOLEShares6.49M
TypeSH
Market value$84.89M
1.51%
Sole
6.49M
Shared
0.00
None
0.00
MEIRAGTX HLDGS PLC
SOLEShares10.33M
TypeSH
Market value$82.09M
1.46%
Sole
10.33M
Shared
0.00
None
0.00
ARTIVION INC
SOLEShares1.72M
TypeSH
Market value$78.55M
1.40%
Sole
1.72M
Shared
0.00
None
0.00
CENTESSA PHARMACEUTICALS PLC
SOLEShares2.92M
TypeSH
Market value$72.97M
1.30%
Sole
2.92M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
PRAXIS PRECISION MEDICINES ISOLE | COM NEW | 2M | SH | $588.30M 10.49% | 2M | 0.00 | 0.00 |
CELCUITY INCSOLE | COM | 3.16M | SH | $315.20M 5.62% | 3.16M | 0.00 | 0.00 |
RHYTHM PHARMACEUTICALS INCSOLE | COM | 2.55M | SH | $272.57M 4.86% | 2.55M | 0.00 | 0.00 |
ASCENDIS PHARMA A/SSOLE | SPONSORED ADR | 1.08M | SH | $230.60M 4.11% | 1.08M | 0.00 | 0.00 |
APOGEE THERAPEUTICS INCSOLE | COM | 2.33M | SH | $175.92M 3.14% | 2.33M | 0.00 | 0.00 |
ROIVANT SCIENCES LTDSOLE | SHS | 7.99M | SH | $173.28M 3.09% | 7.99M | 0.00 | 0.00 |
NUVALENT INCSOLE | COM | 1.67M | SH | $167.49M 2.99% | 1.67M | 0.00 | 0.00 |
TRAVERE THERAPEUTICS INCSOLE | COM | 4.28M | SH | $163.47M 2.91% | 4.28M | 0.00 | 0.00 |
SPDR SERIES TRUSTSOLE | STATE STREET SPD | 1.10M | SH | $134.12M 2.39% | 1.10M | 0.00 | 0.00 |
EXACT SCIENCES CORPSOLE | COM | 1.20M | SH | $121.92M 2.17% | 1.20M | 0.00 | 0.00 |
PROTAGONIST THERAPEUTICS INCSOLE | COM | 1.35M | SH | $117.95M 2.10% | 1.35M | 0.00 | 0.00 |
INHIBRX BIOSCIENCES INCSOLE | COM | 1.45M | SH | $114.76M 2.05% | 1.45M | 0.00 | 0.00 |
EDGEWISE THERAPEUTICSSOLE | COM | 4.46M | SH | $110.62M 1.97% | 4.46M | 0.00 | 0.00 |
IMMATICS N.VSOLE | SHS | 10.38M | SH | $109.03M 1.94% | 10.38M | 0.00 | 0.00 |
SPYRE THERAPEUTICS INCSOLE | COM NEW | 3.07M | SH | $100.55M 1.79% | 3.07M | 0.00 | 0.00 |
AMYLYX PHARMACEUTICALS INCSOLE | COM | 8.28M | SH | $100.08M 1.78% | 8.28M | 0.00 | 0.00 |
ARCELLX INCSOLE | COMMON STOCK | 1.47M | SH | $95.59M 1.70% | 1.47M | 0.00 | 0.00 |
VIRIDIAN THERAPEUTICS INCSOLE | COM | 3.04M | SH | $94.69M 1.69% | 3.04M | 0.00 | 0.00 |
BOSTON SCIENTIFIC CORPSOLE | COM | 979K | SH | $93.35M 1.66% | 979K | 0.00 | 0.00 |
AMICUS THERAPEUTICS INCSOLE | COM | 6.37M | SH | $90.72M 1.62% | 6.37M | 0.00 | 0.00 |
ZYMEWORKS INCSOLE | COM | 3.26M | SH | $85.88M 1.53% | 3.26M | 0.00 | 0.00 |
ASTRIA THERAPEUTICS INCSOLE | COM | 6.49M | SH | $84.89M 1.51% | 6.49M | 0.00 | 0.00 |
MEIRAGTX HLDGS PLCSOLE | COM | 10.33M | SH | $82.09M 1.46% | 10.33M | 0.00 | 0.00 |
ARTIVION INCSOLE | COM | 1.72M | SH | $78.55M 1.40% | 1.72M | 0.00 | 0.00 |
CENTESSA PHARMACEUTICALS PLCSOLE | SPONSORED ADS | 2.92M | SH | $72.97M 1.30% | 2.92M | 0.00 | 0.00 |
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