Filed: 11/14/2025ACC: 0001012975-25-000762
📋 What this filing means
PERCEPTIVE ADVISORS LLC filed this quarterly 13F‑HR report disclosing 93 equity positions with a total reported market value of $3.46B. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
93
Positions
$3.46B
Total AUM (reported)
615.78M
Total Shares
Allocation by class
COM$2.30B66.3%
COM NEW$255.87M7.4%
SPONSORED ADR$216.40M6.2%
COMMON STOCK$205.27M5.9%
SHS$192.60M5.6%
SPONSORED ADS$167.80M4.8%
COM PAR $.01$101.11M2.9%
Portfolio Concentration
Top 3$665.37M19.2%
4–10$846.60M24.4%
11–25$1.00B29.0%
Rest$948.03M27.4%
Top 3 weight
19.2%
Top 10 weight
43.7%
Voting Authority Distribution
Total shares with voting rights: 615.78M
Sole
Full voting authority
615.78M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole93
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings93
Rows:
RHYTHM PHARMACEUTICALS INC
SOLEShares2.44M
TypeSH
Market value$246.31M
7.11%
Sole
2.44M
Shared
0.00
None
0.00
ASCENDIS PHARMA A/S
SOLEShares1.09M
TypeSH
Market value$216.40M
6.25%
Sole
1.09M
Shared
0.00
None
0.00
ARCELLX INC
SOLEShares2.47M
TypeSH
Market value$202.65M
5.85%
Sole
2.47M
Shared
0.00
None
0.00
CELCUITY INC
SOLEShares2.96M
TypeSH
Market value$146.04M
4.22%
Sole
2.96M
Shared
0.00
None
0.00
NUVALENT INC
SOLEShares1.56M
TypeSH
Market value$135.11M
3.90%
Sole
1.56M
Shared
0.00
None
0.00
MERUS N V
SOLEShares1.35M
TypeSH
Market value$127.39M
3.68%
Sole
1.35M
Shared
0.00
None
0.00
AMYLYX PHARMACEUTICALS INC
SOLEShares8.95M
TypeSH
Market value$121.66M
3.51%
Sole
8.95M
Shared
0.00
None
0.00
ROIVANT SCIENCES LTD
SOLEShares7.37M
TypeSH
Market value$111.48M
3.22%
Sole
7.37M
Shared
0.00
None
0.00
MEIRAGTX HLDGS PLC
SOLEShares12.63M
TypeSH
Market value$103.79M
3.00%
Sole
12.63M
Shared
0.00
None
0.00
INSMED INC
SOLEShares702.13K
TypeSH
Market value$101.11M
2.92%
Sole
702.13K
Shared
0.00
None
0.00
TRAVERE THERAPEUTICS INC
SOLEShares3.79M
TypeSH
Market value$90.69M
2.62%
Sole
3.79M
Shared
0.00
None
0.00
ARTIVION INC
SOLEShares2.02M
TypeSH
Market value$85.53M
2.47%
Sole
2.02M
Shared
0.00
None
0.00
PRAXIS PRECISION MEDICINES I
SOLEShares1.56M
TypeSH
Market value$82.92M
2.39%
Sole
1.56M
Shared
0.00
None
0.00
IMMATICS N.V
SOLEShares9.38M
TypeSH
Market value$79.95M
2.31%
Sole
9.38M
Shared
0.00
None
0.00
CENTESSA PHARMACEUTICALS PLC
SOLEShares3.10M
TypeSH
Market value$75.20M
2.17%
Sole
3.10M
Shared
0.00
None
0.00
SOLID BIOSCIENCES INC
SOLEShares11.83M
TypeSH
Market value$73.01M
2.11%
Sole
11.83M
Shared
0.00
None
0.00
PROTAGONIST THERAPEUTICS INC
SOLEShares1.03M
TypeSH
Market value$68.43M
1.98%
Sole
1.03M
Shared
0.00
None
0.00
NEUROCRINE BIOSCIENCES INC
SOLEShares450.05K
TypeSH
Market value$63.18M
1.82%
Sole
450.05K
Shared
0.00
None
0.00
EDGEWISE THERAPEUTICS INC
SOLEShares3.80M
TypeSH
Market value$61.57M
1.78%
Sole
3.80M
Shared
0.00
None
0.00
VERONA PHARMA PLC
SOLEShares524.09K
TypeSH
Market value$55.93M
1.61%
Sole
524.09K
Shared
0.00
None
0.00
PENUMBRA INC
SOLEShares220.55K
TypeSH
Market value$55.87M
1.61%
Sole
220.55K
Shared
0.00
None
0.00
AKERO THERAPEUTICS INC
SOLEShares1.14M
TypeSH
Market value$53.93M
1.56%
Sole
1.14M
Shared
0.00
None
0.00
APOGEE THERAPEUTICS INC
SOLEShares1.35M
TypeSH
Market value$53.71M
1.55%
Sole
1.35M
Shared
0.00
None
0.00
OMADA HEALTH INC
SOLEShares2.40M
TypeSH
Market value$52.98M
1.53%
Sole
2.40M
Shared
0.00
None
0.00
AMICUS THERAPEUTICS INC
SOLEShares6.37M
TypeSH
Market value$50.20M
1.45%
Sole
6.37M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
RHYTHM PHARMACEUTICALS INCSOLE | COM | 2.44M | SH | $246.31M 7.11% | 2.44M | 0.00 | 0.00 |
ASCENDIS PHARMA A/SSOLE | SPONSORED ADR | 1.09M | SH | $216.40M 6.25% | 1.09M | 0.00 | 0.00 |
ARCELLX INCSOLE | COMMON STOCK | 2.47M | SH | $202.65M 5.85% | 2.47M | 0.00 | 0.00 |
CELCUITY INCSOLE | COM | 2.96M | SH | $146.04M 4.22% | 2.96M | 0.00 | 0.00 |
NUVALENT INCSOLE | COM | 1.56M | SH | $135.11M 3.90% | 1.56M | 0.00 | 0.00 |
MERUS N VSOLE | COM | 1.35M | SH | $127.39M 3.68% | 1.35M | 0.00 | 0.00 |
AMYLYX PHARMACEUTICALS INCSOLE | COM | 8.95M | SH | $121.66M 3.51% | 8.95M | 0.00 | 0.00 |
ROIVANT SCIENCES LTDSOLE | SHS | 7.37M | SH | $111.48M 3.22% | 7.37M | 0.00 | 0.00 |
MEIRAGTX HLDGS PLCSOLE | COM | 12.63M | SH | $103.79M 3.00% | 12.63M | 0.00 | 0.00 |
INSMED INCSOLE | COM PAR $.01 | 702.13K | SH | $101.11M 2.92% | 702.13K | 0.00 | 0.00 |
TRAVERE THERAPEUTICS INCSOLE | COM | 3.79M | SH | $90.69M 2.62% | 3.79M | 0.00 | 0.00 |
ARTIVION INCSOLE | COM | 2.02M | SH | $85.53M 2.47% | 2.02M | 0.00 | 0.00 |
PRAXIS PRECISION MEDICINES ISOLE | COM NEW | 1.56M | SH | $82.92M 2.39% | 1.56M | 0.00 | 0.00 |
IMMATICS N.VSOLE | SHS | 9.38M | SH | $79.95M 2.31% | 9.38M | 0.00 | 0.00 |
CENTESSA PHARMACEUTICALS PLCSOLE | SPONSORED ADS | 3.10M | SH | $75.20M 2.17% | 3.10M | 0.00 | 0.00 |
SOLID BIOSCIENCES INCSOLE | COM NEW | 11.83M | SH | $73.01M 2.11% | 11.83M | 0.00 | 0.00 |
PROTAGONIST THERAPEUTICS INCSOLE | COM | 1.03M | SH | $68.43M 1.98% | 1.03M | 0.00 | 0.00 |
NEUROCRINE BIOSCIENCES INCSOLE | COM | 450.05K | SH | $63.18M 1.82% | 450.05K | 0.00 | 0.00 |
EDGEWISE THERAPEUTICS INCSOLE | COM | 3.80M | SH | $61.57M 1.78% | 3.80M | 0.00 | 0.00 |
VERONA PHARMA PLCSOLE | SPONSORED ADS | 524.09K | SH | $55.93M 1.61% | 524.09K | 0.00 | 0.00 |
PENUMBRA INCSOLE | COM | 220.55K | SH | $55.87M 1.61% | 220.55K | 0.00 | 0.00 |
AKERO THERAPEUTICS INCSOLE | COM | 1.14M | SH | $53.93M 1.56% | 1.14M | 0.00 | 0.00 |
APOGEE THERAPEUTICS INCSOLE | COM | 1.35M | SH | $53.71M 1.55% | 1.35M | 0.00 | 0.00 |
OMADA HEALTH INCSOLE | COM | 2.40M | SH | $52.98M 1.53% | 2.40M | 0.00 | 0.00 |
AMICUS THERAPEUTICS INCSOLE | COM | 6.37M | SH | $50.20M 1.45% | 6.37M | 0.00 | 0.00 |
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