PATEL DINESH V PH D (President and CEO) sold 7.8% of their position (48.27K shares) of PROTAGONIST THERAPEUTICS, INC on the open market

Open‑market sale worth $4.06M — a moderate reduction. Review remaining holdings and any 10b5‑1 plan disclosures.

S · 4 sales

PATEL DINESH V PH D

Filed: 1/27/2026ACC: 0001104659-26-007129

InsiderPATEL DINESH V PH DCIK 1120477

→

IssuerPROTAGONIST THERAPEUTICS, INCCIK 1377121

DirectorOfficer· President and CEO

Since Jul 2018

-54.27K

Net shares

Net seller

$4.06M

Total sold

Open market trades

0B · 4S

Total transactions

48.27K acquired · 102.55K disposed

Non-Derivative Transactions9

Common Stock

Direct

G · Gift

−6K

Price / share

—

Trade value

—

% of position

1.0%

1/23/2026

580.50K→574.50K

Common Stock

Direct

M · Option Exercise

+19.32K

Price / share

$4.21

Trade value

$81.32K

% of position

3.4%

1/23/2026

574.50K→593.82K

Common Stock

Direct

S · Sale

−19.32K

Price / share

$84.59

Trade value

$1.63M

% of position

3.3%

1/23/2026

593.82K→574.50K

Common Stock

Direct

M · Option Exercise

+10.69K

Price / share

$4.21

Trade value

$44.98K

% of position

1.9%

1/26/2026

574.50K→585.19K

Common Stock

Direct

S · Sale

−10.69K

Price / share

$84.00

Trade value

$897.54K

% of position

1.8%

1/26/2026

585.19K→574.50K

Common Stock

Direct

M · Option Exercise

+14.21K

Price / share

$21.58

Trade value

$306.54K

% of position

2.5%

1/26/2026

574.50K→588.71K

Common Stock

Direct

S · Sale

−14.21K

Price / share

$84.05

Trade value

$1.19M

% of position

2.4%

1/26/2026

588.71K→574.50K

Common Stock

Direct

M · Option Exercise

+4.07K

Price / share

$21.58

Trade value

$87.79K

% of position

0.7%

1/27/2026

574.50K→578.57K

Common Stock

Direct

S · Sale

−4.07K

Price / share

$83.19

Trade value

$338.42K

% of position

0.7%

1/27/2026

578.57K→574.50K

Total

Net shares

−6K

Net value

-$3.54M

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Direct	1/23/2026	G · Gift	−6K	—	—	1.0%	580.50K	574.50K
Common Stock Direct	1/23/2026	M · Option Exercise	+19.32K	$4.21	$81.32K	3.4%	574.50K	593.82K
Common Stock Direct	1/23/2026	S · Sale	−19.32K	$84.59	$1.63M	3.3%	593.82K	574.50K
Common Stock Direct	1/26/2026	M · Option Exercise	+10.69K	$4.21	$44.98K	1.9%	574.50K	585.19K
Common Stock Direct	1/26/2026	S · Sale	−10.69K	$84.00	$897.54K	1.8%	585.19K	574.50K
Common Stock Direct	1/26/2026	M · Option Exercise	+14.21K	$21.58	$306.54K	2.5%	574.50K	588.71K
Common Stock Direct	1/26/2026	S · Sale	−14.21K	$84.05	$1.19M	2.4%	588.71K	574.50K
Common Stock Direct	1/27/2026	M · Option Exercise	+4.07K	$21.58	$87.79K	0.7%	574.50K	578.57K
Common Stock Direct	1/27/2026	S · Sale	−4.07K	$83.19	$338.42K	0.7%	578.57K	574.50K
Total			−6K		-$3.54M

Derivative Transactions4

Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

19.32K shares

−19.32K

Strike price

4.21

Held after

10.69K

Exercisable

—

1/23/2026

Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

10.69K shares

−10.69K

Strike price

4.21

Held after

0.00

Exercisable

—

1/26/2026

Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

14.21K shares

−14.21K

Strike price

21.58

Held after

304.07K

Exercisable

—

1/26/2026

Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

4.07K shares

−4.07K

Strike price

21.58

Held after

300K

Exercisable

—

1/27/2026

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Stock Option (right to buy) Direct	Common Stock19.32K shares	1/23/2026	M · Option Exercise	−19.32K	4.21	—	10.69K
Stock Option (right to buy) Direct	Common Stock10.69K shares	1/26/2026	M · Option Exercise	−10.69K	4.21	—	0.00
Stock Option (right to buy) Direct	Common Stock14.21K shares	1/26/2026	M · Option Exercise	−14.21K	21.58	—	304.07K
Stock Option (right to buy) Direct	Common Stock4.07K shares	1/27/2026	M · Option Exercise	−4.07K	21.58	—	300K