Filed: 11/14/2025ACC: 0001855655-25-000014
📋 What this filing means
PARADIGM BIOCAPITAL ADVISORS LP filed this quarterly 13F‑HR report disclosing 34 equity positions with a total reported market value of $3.52B. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
34
Positions
$3.52B
Total AUM (reported)
104.64M
Total Shares
Allocation by class
COM$2.56B72.7%
COMMON STOCK$381.68M10.9%
SPONSORED ADS$260.30M7.4%
COM NEW$166.80M4.7%
S&P BIOTECH$100.20M2.8%
SHS$51.58M1.5%
Portfolio Concentration
Top 3$1.28B36.3%
4–10$1.06B30.1%
11–25$975.06M27.7%
Rest$206.89M5.9%
Top 3 weight
36.3%
Top 10 weight
66.4%
Voting Authority Distribution
Total shares with voting rights: 104.64M
Sole
Full voting authority
104.64M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole34
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings34
Rows:
NUVALENT INC
SOLEShares5.27M
TypeSH
Market value$455.70M
12.96%
Sole
5.27M
Shared
0.00
None
0.00
MERUS N V
SOLEShares4.67M
TypeSH
Market value$440.04M
12.51%
Sole
4.67M
Shared
0.00
None
0.00
ARCELLX INC
SOLEShares4.65M
TypeSH
Market value$381.68M
10.86%
Sole
4.65M
Shared
0.00
None
0.00
REVOLUTION MEDICINES INC
SOLEShares6.22M
TypeSH
Market value$290.63M
8.27%
Sole
6.22M
Shared
0.00
None
0.00
TARSUS PHARMACEUTICALS INC
SOLEShares2.67M
TypeSH
Market value$158.42M
4.51%
Sole
2.67M
Shared
0.00
None
0.00
VAXCYTE INC
SOLEShares3.78M
TypeSH
Market value$136.33M
3.88%
Sole
3.78M
Shared
0.00
None
0.00
ABIVAX SA
SOLEShares1.56M
TypeSH
Market value$132.80M
3.78%
Sole
1.56M
Shared
0.00
None
0.00
GENMAB A/S
SOLEShares3.82M
TypeSH
Market value$117.06M
3.33%
Sole
3.82M
Shared
0.00
None
0.00
AGIOS PHARMACEUTICALS INC
SOLEShares2.87M
TypeSH
Market value$115.34M
3.28%
Sole
2.87M
Shared
0.00
None
0.00
CRINETICS PHARMACEUTICALS IN
SOLEShares2.55M
TypeSH
Market value$106.24M
3.02%
Sole
2.55M
Shared
0.00
None
0.00
SPDR SERIES TRUST
SOLEShares1M
TypeSH
Market value$100.20M
2.85%
Sole
1M
Shared
0.00
None
0.00
EDGEWISE THERAPEUTICS INC
SOLEShares6.17M
TypeSH
Market value$100.08M
2.85%
Sole
6.17M
Shared
0.00
None
0.00
CIDARA THERAPEUTICS INC
SOLEShares961.16K
TypeSH
Market value$92.04M
2.62%
Sole
961.16K
Shared
0.00
None
0.00
UROGEN PHARMA LTD
SOLEShares4.22M
TypeSH
Market value$84.11M
2.39%
Sole
4.22M
Shared
0.00
None
0.00
SCHOLAR ROCK HLDG CORP
SOLEShares2.01M
TypeSH
Market value$74.84M
2.13%
Sole
2.01M
Shared
0.00
None
0.00
JANUX THERAPEUTICS INC
SOLEShares2.92M
TypeSH
Market value$71.37M
2.03%
Sole
2.92M
Shared
0.00
None
0.00
OLEMA PHARMACEUTICALS INC
SOLEShares6.79M
TypeSH
Market value$66.51M
1.89%
Sole
6.79M
Shared
0.00
None
0.00
APOGEE THERAPEUTICS INC
SOLEShares1.52M
TypeSH
Market value$60.46M
1.72%
Sole
1.52M
Shared
0.00
None
0.00
VIRIDIAN THERAPEUTICS INC
SOLEShares2.61M
TypeSH
Market value$56.31M
1.60%
Sole
2.61M
Shared
0.00
None
0.00
ALKERMES PLC
SOLEShares1.72M
TypeSH
Market value$51.58M
1.47%
Sole
1.72M
Shared
0.00
None
0.00
LENZ THERAPEUTICS INC
SOLEShares1.07M
TypeSH
Market value$50.00M
1.42%
Sole
1.07M
Shared
0.00
None
0.00
PHARVARIS N V
SOLEShares1.84M
TypeSH
Market value$45.80M
1.30%
Sole
1.84M
Shared
0.00
None
0.00
COGENT BIOSCIENCES INC
SOLEShares3.16M
TypeSH
Market value$45.33M
1.29%
Sole
3.16M
Shared
0.00
None
0.00
OCULAR THERAPEUTIX INC
SOLEShares3.50M
TypeSH
Market value$40.88M
1.16%
Sole
3.50M
Shared
0.00
None
0.00
BRIDGEBIO PHARMA INC
SOLEShares684.28K
TypeSH
Market value$35.54M
1.01%
Sole
684.28K
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
NUVALENT INCSOLE | COM | 5.27M | SH | $455.70M 12.96% | 5.27M | 0.00 | 0.00 |
MERUS N VSOLE | COM | 4.67M | SH | $440.04M 12.51% | 4.67M | 0.00 | 0.00 |
ARCELLX INCSOLE | COMMON STOCK | 4.65M | SH | $381.68M 10.86% | 4.65M | 0.00 | 0.00 |
REVOLUTION MEDICINES INCSOLE | COM | 6.22M | SH | $290.63M 8.27% | 6.22M | 0.00 | 0.00 |
TARSUS PHARMACEUTICALS INCSOLE | COM | 2.67M | SH | $158.42M 4.51% | 2.67M | 0.00 | 0.00 |
VAXCYTE INCSOLE | COM | 3.78M | SH | $136.33M 3.88% | 3.78M | 0.00 | 0.00 |
ABIVAX SASOLE | SPONSORED ADS | 1.56M | SH | $132.80M 3.78% | 1.56M | 0.00 | 0.00 |
GENMAB A/SSOLE | SPONSORED ADS | 3.82M | SH | $117.06M 3.33% | 3.82M | 0.00 | 0.00 |
AGIOS PHARMACEUTICALS INCSOLE | COM | 2.87M | SH | $115.34M 3.28% | 2.87M | 0.00 | 0.00 |
CRINETICS PHARMACEUTICALS INSOLE | COM | 2.55M | SH | $106.24M 3.02% | 2.55M | 0.00 | 0.00 |
SPDR SERIES TRUSTSOLE | S&P BIOTECH | 1M | SH | $100.20M 2.85% | 1M | 0.00 | 0.00 |
EDGEWISE THERAPEUTICS INCSOLE | COM | 6.17M | SH | $100.08M 2.85% | 6.17M | 0.00 | 0.00 |
CIDARA THERAPEUTICS INCSOLE | COM NEW | 961.16K | SH | $92.04M 2.62% | 961.16K | 0.00 | 0.00 |
UROGEN PHARMA LTDSOLE | COM | 4.22M | SH | $84.11M 2.39% | 4.22M | 0.00 | 0.00 |
SCHOLAR ROCK HLDG CORPSOLE | COM | 2.01M | SH | $74.84M 2.13% | 2.01M | 0.00 | 0.00 |
JANUX THERAPEUTICS INCSOLE | COM | 2.92M | SH | $71.37M 2.03% | 2.92M | 0.00 | 0.00 |
OLEMA PHARMACEUTICALS INCSOLE | COM | 6.79M | SH | $66.51M 1.89% | 6.79M | 0.00 | 0.00 |
APOGEE THERAPEUTICS INCSOLE | COM | 1.52M | SH | $60.46M 1.72% | 1.52M | 0.00 | 0.00 |
VIRIDIAN THERAPEUTICS INCSOLE | COM | 2.61M | SH | $56.31M 1.60% | 2.61M | 0.00 | 0.00 |
ALKERMES PLCSOLE | SHS | 1.72M | SH | $51.58M 1.47% | 1.72M | 0.00 | 0.00 |
LENZ THERAPEUTICS INCSOLE | COM | 1.07M | SH | $50.00M 1.42% | 1.07M | 0.00 | 0.00 |
PHARVARIS N VSOLE | COM | 1.84M | SH | $45.80M 1.30% | 1.84M | 0.00 | 0.00 |
COGENT BIOSCIENCES INCSOLE | COM | 3.16M | SH | $45.33M 1.29% | 3.16M | 0.00 | 0.00 |
OCULAR THERAPEUTIX INCSOLE | COM | 3.50M | SH | $40.88M 1.16% | 3.50M | 0.00 | 0.00 |
BRIDGEBIO PHARMA INCSOLE | COM | 684.28K | SH | $35.54M 1.01% | 684.28K | 0.00 | 0.00 |
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