Filed: 8/14/2025ACC: 0001855655-25-000010
📋 What this filing means
PARADIGM BIOCAPITAL ADVISORS LP filed this quarterly 13F‑HR report disclosing 28 equity positions with a total reported market value of $2.34B. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
28
Positions
$2.34B
Total AUM (reported)
94.39M
Total Shares
Allocation by class
COM$1.83B78.0%
COMMON STOCK$306.14M13.1%
SPONSORED ADS$84.19M3.6%
SHS$56.27M2.4%
CLASS A ORD$41.46M1.8%
COM NEW$28.00M1.2%
Portfolio Concentration
Top 3$933.43M39.9%
4–10$760.89M32.5%
11–25$605.40M25.8%
Rest$42.41M1.8%
Top 3 weight
39.9%
Top 10 weight
72.3%
Voting Authority Distribution
Total shares with voting rights: 94.39M
Sole
Full voting authority
94.39M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole28
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings28
Rows:
NUVALENT INC
SOLEShares5.27M
TypeSH
Market value$402.06M
17.17%
Sole
5.27M
Shared
0.00
None
0.00
ARCELLX INC
SOLEShares4.65M
TypeSH
Market value$306.14M
13.07%
Sole
4.65M
Shared
0.00
None
0.00
MERUS N V
SOLEShares4.28M
TypeSH
Market value$225.23M
9.62%
Sole
4.28M
Shared
0.00
None
0.00
REVOLUTION MEDICINES INC
SOLEShares6.09M
TypeSH
Market value$224.17M
9.57%
Sole
6.09M
Shared
0.00
None
0.00
TARSUS PHARMACEUTICALS INC
SOLEShares2.98M
TypeSH
Market value$120.56M
5.15%
Sole
2.98M
Shared
0.00
None
0.00
VAXCYTE INC
SOLEShares3.37M
TypeSH
Market value$109.65M
4.68%
Sole
3.37M
Shared
0.00
None
0.00
BEONE MEDICINES LTD
SOLEShares347.79K
TypeSH
Market value$84.19M
3.59%
Sole
347.79K
Shared
0.00
None
0.00
EDGEWISE THERAPEUTICS INC
SOLEShares6.14M
TypeSH
Market value$80.53M
3.44%
Sole
6.14M
Shared
0.00
None
0.00
COGENT BIOSCIENCES INC
SOLEShares10.35M
TypeSH
Market value$74.33M
3.17%
Sole
10.35M
Shared
0.00
None
0.00
JANUX THERAPEUTICS INC
SOLEShares2.92M
TypeSH
Market value$67.46M
2.88%
Sole
2.92M
Shared
0.00
None
0.00
CRINETICS PHARMACEUTICALS IN
SOLEShares2.34M
TypeSH
Market value$67.40M
2.88%
Sole
2.34M
Shared
0.00
None
0.00
DISC MEDICINE INC
SOLEShares1.21M
TypeSH
Market value$64.13M
2.74%
Sole
1.21M
Shared
0.00
None
0.00
SCHOLAR ROCK HLDG CORP
SOLEShares1.60M
TypeSH
Market value$56.69M
2.42%
Sole
1.60M
Shared
0.00
None
0.00
LENZ THERAPEUTICS INC
SOLEShares1.72M
TypeSH
Market value$50.33M
2.15%
Sole
1.72M
Shared
0.00
None
0.00
BRIDGEBIO PHARMA INC
SOLEShares965.76K
TypeSH
Market value$41.70M
1.78%
Sole
965.76K
Shared
0.00
None
0.00
APOGEE THERAPEUTICS INC
SOLEShares958.63K
TypeSH
Market value$41.63M
1.78%
Sole
958.63K
Shared
0.00
None
0.00
MOONLAKE IMMUNOTHERAPEUTICS
SOLEShares878.32K
TypeSH
Market value$41.46M
1.77%
Sole
878.32K
Shared
0.00
None
0.00
ALKERMES PLC
SOLEShares1.38M
TypeSH
Market value$39.36M
1.68%
Sole
1.38M
Shared
0.00
None
0.00
VIRIDIAN THERAPEUTICS INC
SOLEShares2.74M
TypeSH
Market value$38.33M
1.64%
Sole
2.74M
Shared
0.00
None
0.00
AGIOS PHARMACEUTICALS INC
SOLEShares1.14M
TypeSH
Market value$38.00M
1.62%
Sole
1.14M
Shared
0.00
None
0.00
OCULAR THERAPEUTIX INC
SOLEShares3.42M
TypeSH
Market value$31.74M
1.36%
Sole
3.42M
Shared
0.00
None
0.00
OLEMA PHARMACEUTICALS INC
SOLEShares6.76M
TypeSH
Market value$28.82M
1.23%
Sole
6.76M
Shared
0.00
None
0.00
SPYRE THERAPEUTICS INC
SOLEShares1.87M
TypeSH
Market value$28.00M
1.20%
Sole
1.87M
Shared
0.00
None
0.00
Y-MABS THERAPEUTICS INC
SOLEShares4.24M
TypeSH
Market value$19.11M
0.82%
Sole
4.24M
Shared
0.00
None
0.00
PHARVARIS N V
SOLEShares1.06M
TypeSH
Market value$18.71M
0.80%
Sole
1.06M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
NUVALENT INCSOLE | COM | 5.27M | SH | $402.06M 17.17% | 5.27M | 0.00 | 0.00 |
ARCELLX INCSOLE | COMMON STOCK | 4.65M | SH | $306.14M 13.07% | 4.65M | 0.00 | 0.00 |
MERUS N VSOLE | COM | 4.28M | SH | $225.23M 9.62% | 4.28M | 0.00 | 0.00 |
REVOLUTION MEDICINES INCSOLE | COM | 6.09M | SH | $224.17M 9.57% | 6.09M | 0.00 | 0.00 |
TARSUS PHARMACEUTICALS INCSOLE | COM | 2.98M | SH | $120.56M 5.15% | 2.98M | 0.00 | 0.00 |
VAXCYTE INCSOLE | COM | 3.37M | SH | $109.65M 4.68% | 3.37M | 0.00 | 0.00 |
BEONE MEDICINES LTDSOLE | SPONSORED ADS | 347.79K | SH | $84.19M 3.59% | 347.79K | 0.00 | 0.00 |
EDGEWISE THERAPEUTICS INCSOLE | COM | 6.14M | SH | $80.53M 3.44% | 6.14M | 0.00 | 0.00 |
COGENT BIOSCIENCES INCSOLE | COM | 10.35M | SH | $74.33M 3.17% | 10.35M | 0.00 | 0.00 |
JANUX THERAPEUTICS INCSOLE | COM | 2.92M | SH | $67.46M 2.88% | 2.92M | 0.00 | 0.00 |
CRINETICS PHARMACEUTICALS INSOLE | COM | 2.34M | SH | $67.40M 2.88% | 2.34M | 0.00 | 0.00 |
DISC MEDICINE INCSOLE | COM | 1.21M | SH | $64.13M 2.74% | 1.21M | 0.00 | 0.00 |
SCHOLAR ROCK HLDG CORPSOLE | COM | 1.60M | SH | $56.69M 2.42% | 1.60M | 0.00 | 0.00 |
LENZ THERAPEUTICS INCSOLE | COM | 1.72M | SH | $50.33M 2.15% | 1.72M | 0.00 | 0.00 |
BRIDGEBIO PHARMA INCSOLE | COM | 965.76K | SH | $41.70M 1.78% | 965.76K | 0.00 | 0.00 |
APOGEE THERAPEUTICS INCSOLE | COM | 958.63K | SH | $41.63M 1.78% | 958.63K | 0.00 | 0.00 |
MOONLAKE IMMUNOTHERAPEUTICSSOLE | CLASS A ORD | 878.32K | SH | $41.46M 1.77% | 878.32K | 0.00 | 0.00 |
ALKERMES PLCSOLE | SHS | 1.38M | SH | $39.36M 1.68% | 1.38M | 0.00 | 0.00 |
VIRIDIAN THERAPEUTICS INCSOLE | COM | 2.74M | SH | $38.33M 1.64% | 2.74M | 0.00 | 0.00 |
AGIOS PHARMACEUTICALS INCSOLE | COM | 1.14M | SH | $38.00M 1.62% | 1.14M | 0.00 | 0.00 |
OCULAR THERAPEUTIX INCSOLE | COM | 3.42M | SH | $31.74M 1.36% | 3.42M | 0.00 | 0.00 |
OLEMA PHARMACEUTICALS INCSOLE | COM | 6.76M | SH | $28.82M 1.23% | 6.76M | 0.00 | 0.00 |
SPYRE THERAPEUTICS INCSOLE | COM NEW | 1.87M | SH | $28.00M 1.20% | 1.87M | 0.00 | 0.00 |
Y-MABS THERAPEUTICS INCSOLE | COM | 4.24M | SH | $19.11M 0.82% | 4.24M | 0.00 | 0.00 |
PHARVARIS N VSOLE | COM | 1.06M | SH | $18.71M 0.80% | 1.06M | 0.00 | 0.00 |
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