Filed: 5/15/2025ACC: 0001855655-25-000007
📋 What this filing means
PARADIGM BIOCAPITAL ADVISORS LP filed this quarterly 13F‑HR report disclosing 27 equity positions with a total reported market value of $2.18B. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
27
Positions
$2.18B
Total AUM (reported)
80.98M
Total Shares
Allocation by class
COM$1.54B70.3%
COMMON STOCK$294.68M13.5%
SPONSORED ADS$181.27M8.3%
COM NEW$68.83M3.2%
SPONSORED ADR$35.32M1.6%
COM PAR $.01$34.43M1.6%
CLASS A ORD$24.51M1.1%
Portfolio Concentration
Top 3$886.84M40.6%
4–10$784.11M35.9%
11–25$494.21M22.6%
Rest$18.23M0.8%
Top 3 weight
40.6%
Top 10 weight
76.5%
Voting Authority Distribution
Total shares with voting rights: 80.98M
Sole
Full voting authority
80.98M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole27
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings27
Rows:
NUVALENT INC
SOLEShares5.27M
TypeSH
Market value$373.71M
17.12%
Sole
5.27M
Shared
0.00
None
0.00
ARCELLX INC
SOLEShares4.49M
TypeSH
Market value$294.68M
13.50%
Sole
4.49M
Shared
0.00
None
0.00
REVOLUTION MEDICINES INC
SOLEShares6.18M
TypeSH
Market value$218.46M
10.01%
Sole
6.18M
Shared
0.00
None
0.00
BEIGENE LTD
SOLEShares666.02K
TypeSH
Market value$181.27M
8.30%
Sole
666.02K
Shared
0.00
None
0.00
MERUS N V
SOLEShares3.37M
TypeSH
Market value$141.83M
6.50%
Sole
3.37M
Shared
0.00
None
0.00
TARSUS PHARMACEUTICALS INC
SOLEShares2.61M
TypeSH
Market value$134.09M
6.14%
Sole
2.61M
Shared
0.00
None
0.00
EDGEWISE THERAPEUTICS INC
SOLEShares4.89M
TypeSH
Market value$107.68M
4.93%
Sole
4.89M
Shared
0.00
None
0.00
JANUX THERAPEUTICS INC
SOLEShares3.33M
TypeSH
Market value$89.91M
4.12%
Sole
3.33M
Shared
0.00
None
0.00
CRINETICS PHARMACEUTICALS IN
SOLEShares1.95M
TypeSH
Market value$65.27M
2.99%
Sole
1.95M
Shared
0.00
None
0.00
VAXCYTE INC
SOLEShares1.70M
TypeSH
Market value$64.06M
2.93%
Sole
1.70M
Shared
0.00
None
0.00
DISC MEDICINE INC
SOLEShares1.21M
TypeSH
Market value$60.11M
2.75%
Sole
1.21M
Shared
0.00
None
0.00
COGENT BIOSCIENCES INC
SOLEShares8.96M
TypeSH
Market value$53.69M
2.46%
Sole
8.96M
Shared
0.00
None
0.00
LENZ THERAPEUTICS INC
SOLEShares1.51M
TypeSH
Market value$38.87M
1.78%
Sole
1.51M
Shared
0.00
None
0.00
APOGEE THERAPEUTICS INC
SOLEShares961.71K
TypeSH
Market value$35.93M
1.65%
Sole
961.71K
Shared
0.00
None
0.00
ARGENX SE
SOLEShares59.68K
TypeSH
Market value$35.32M
1.62%
Sole
59.68K
Shared
0.00
None
0.00
CYTOKINETICS INC
SOLEShares858.66K
TypeSH
Market value$34.51M
1.58%
Sole
858.66K
Shared
0.00
None
0.00
INSMED INC
SOLEShares451.36K
TypeSH
Market value$34.43M
1.58%
Sole
451.36K
Shared
0.00
None
0.00
SPYRE THERAPEUTICS INC
SOLEShares2.13M
TypeSH
Market value$34.32M
1.57%
Sole
2.13M
Shared
0.00
None
0.00
METSERA INC
SOLEShares1.19M
TypeSH
Market value$32.43M
1.49%
Sole
1.19M
Shared
0.00
None
0.00
VIRIDIAN THERAPEUTICS INC
SOLEShares2.10M
TypeSH
Market value$28.24M
1.29%
Sole
2.10M
Shared
0.00
None
0.00
OLEMA PHARMACEUTICALS INC
SOLEShares6.74M
TypeSH
Market value$25.35M
1.16%
Sole
6.74M
Shared
0.00
None
0.00
MOONLAKE IMMUNOTHERAPEUTICS
SOLEShares627.42K
TypeSH
Market value$24.51M
1.12%
Sole
627.42K
Shared
0.00
None
0.00
ARCUTIS BIOTHERAPEUTICS INC
SOLEShares1.47M
TypeSH
Market value$22.92M
1.05%
Sole
1.47M
Shared
0.00
None
0.00
Y-MABS THERAPEUTICS INC
SOLEShares4.24M
TypeSH
Market value$18.77M
0.86%
Sole
4.24M
Shared
0.00
None
0.00
ERASCA INC
SOLEShares10.80M
TypeSH
Market value$14.80M
0.68%
Sole
10.80M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
NUVALENT INCSOLE | COM | 5.27M | SH | $373.71M 17.12% | 5.27M | 0.00 | 0.00 |
ARCELLX INCSOLE | COMMON STOCK | 4.49M | SH | $294.68M 13.50% | 4.49M | 0.00 | 0.00 |
REVOLUTION MEDICINES INCSOLE | COM | 6.18M | SH | $218.46M 10.01% | 6.18M | 0.00 | 0.00 |
BEIGENE LTDSOLE | SPONSORED ADS | 666.02K | SH | $181.27M 8.30% | 666.02K | 0.00 | 0.00 |
MERUS N VSOLE | COM | 3.37M | SH | $141.83M 6.50% | 3.37M | 0.00 | 0.00 |
TARSUS PHARMACEUTICALS INCSOLE | COM | 2.61M | SH | $134.09M 6.14% | 2.61M | 0.00 | 0.00 |
EDGEWISE THERAPEUTICS INCSOLE | COM | 4.89M | SH | $107.68M 4.93% | 4.89M | 0.00 | 0.00 |
JANUX THERAPEUTICS INCSOLE | COM | 3.33M | SH | $89.91M 4.12% | 3.33M | 0.00 | 0.00 |
CRINETICS PHARMACEUTICALS INSOLE | COM | 1.95M | SH | $65.27M 2.99% | 1.95M | 0.00 | 0.00 |
VAXCYTE INCSOLE | COM | 1.70M | SH | $64.06M 2.93% | 1.70M | 0.00 | 0.00 |
DISC MEDICINE INCSOLE | COM | 1.21M | SH | $60.11M 2.75% | 1.21M | 0.00 | 0.00 |
COGENT BIOSCIENCES INCSOLE | COM | 8.96M | SH | $53.69M 2.46% | 8.96M | 0.00 | 0.00 |
LENZ THERAPEUTICS INCSOLE | COM | 1.51M | SH | $38.87M 1.78% | 1.51M | 0.00 | 0.00 |
APOGEE THERAPEUTICS INCSOLE | COM | 961.71K | SH | $35.93M 1.65% | 961.71K | 0.00 | 0.00 |
ARGENX SESOLE | SPONSORED ADR | 59.68K | SH | $35.32M 1.62% | 59.68K | 0.00 | 0.00 |
CYTOKINETICS INCSOLE | COM NEW | 858.66K | SH | $34.51M 1.58% | 858.66K | 0.00 | 0.00 |
INSMED INCSOLE | COM PAR $.01 | 451.36K | SH | $34.43M 1.58% | 451.36K | 0.00 | 0.00 |
SPYRE THERAPEUTICS INCSOLE | COM NEW | 2.13M | SH | $34.32M 1.57% | 2.13M | 0.00 | 0.00 |
METSERA INCSOLE | COM | 1.19M | SH | $32.43M 1.49% | 1.19M | 0.00 | 0.00 |
VIRIDIAN THERAPEUTICS INCSOLE | COM | 2.10M | SH | $28.24M 1.29% | 2.10M | 0.00 | 0.00 |
OLEMA PHARMACEUTICALS INCSOLE | COM | 6.74M | SH | $25.35M 1.16% | 6.74M | 0.00 | 0.00 |
MOONLAKE IMMUNOTHERAPEUTICSSOLE | CLASS A ORD | 627.42K | SH | $24.51M 1.12% | 627.42K | 0.00 | 0.00 |
ARCUTIS BIOTHERAPEUTICS INCSOLE | COM | 1.47M | SH | $22.92M 1.05% | 1.47M | 0.00 | 0.00 |
Y-MABS THERAPEUTICS INCSOLE | COM | 4.24M | SH | $18.77M 0.86% | 4.24M | 0.00 | 0.00 |
ERASCA INCSOLE | COM | 10.80M | SH | $14.80M 0.68% | 10.80M | 0.00 | 0.00 |
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