Filed: 8/17/2026ACC: 0002073679-26-000096
📋 What this filing means
PALO ALTO INVESTORS LP filed this quarterly 13F‑HR report disclosing 52 equity positions with a total reported market value of $723.72M. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
52
Positions
$723.72M
Total AUM (reported)
36.54M
Total Shares
Allocation by class
COM$534.10M73.8%
COM PAR $.01$44.14M6.1%
NOTE 4.000% 5/0$40.83M5.6%
ORD SHS$31.54M4.4%
COM NEW$25.01M3.5%
SHS$23.90M3.3%
COM SHS$9.48M1.3%
Portfolio Concentration
Top 3$191.55M26.5%
4–10$251.92M34.8%
11–25$219.81M30.4%
Rest$60.43M8.4%
Top 3 weight
26.5%
Top 10 weight
61.3%
Voting Authority Distribution
Total shares with voting rights: 36.54M
Sole
Full voting authority
36.54M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole52
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings52
Rows:
PTC THERAPEUTICS INC
SOLEShares918.85K
TypeSH
Market value$74.95M
10.36%
Sole
918.85K
Shared
0.00
None
0.00
ACADIA PHARMACEUTICALS INC
SOLEShares2.86M
TypeSH
Market value$72.46M
10.01%
Sole
2.86M
Shared
0.00
None
0.00
INSMED INC
SOLEShares413.98K
TypeSH
Market value$44.14M
6.10%
Sole
413.98K
Shared
0.00
None
0.00
MIRUM PHARMACEUTICALS INC
SOLEShares348.81K
TypePRN
Market value$40.83M
5.64%
Sole
348.81K
Shared
0.00
None
0.00
ANAPTYSBIO INC
SOLEShares603.49K
TypeSH
Market value$40.74M
5.63%
Sole
603.49K
Shared
0.00
None
0.00
BIOMARIN PHARMACEUTICAL INC
SOLEShares682.78K
TypeSH
Market value$39.07M
5.40%
Sole
682.78K
Shared
0.00
None
0.00
DYNE THERAPEUTICS INC
SOLEShares1.65M
TypeSH
Market value$36.59M
5.06%
Sole
1.65M
Shared
0.00
None
0.00
UNITED THERAPEUTICS CORP
SOLEShares62.59K
TypeSH
Market value$33.91M
4.69%
Sole
62.59K
Shared
0.00
None
0.00
DISC MEDICINE INC
SOLEShares416.65K
TypeSH
Market value$30.47M
4.21%
Sole
416.65K
Shared
0.00
None
0.00
BIOGEN INC
SOLEShares140.28K
TypeSH
Market value$30.31M
4.19%
Sole
140.28K
Shared
0.00
None
0.00
IOVANCE BIOTHERAPEUTICS INC
SOLEShares5.30M
TypeSH
Market value$22.03M
3.04%
Sole
5.30M
Shared
0.00
None
0.00
ULTRAGENYX PHARMACEUTICAL IN
SOLEShares596.50K
TypeSH
Market value$19.92M
2.75%
Sole
596.50K
Shared
0.00
None
0.00
NOVOCURE LTD
SOLEShares1.28M
TypeSH
Market value$19.40M
2.68%
Sole
1.28M
Shared
0.00
None
0.00
SYNDAX PHARMACEUTICALS INC
SOLEShares864.99K
TypeSH
Market value$18.91M
2.61%
Sole
864.99K
Shared
0.00
None
0.00
ANNEXON INC
SOLEShares2.95M
TypeSH
Market value$16.83M
2.33%
Sole
2.95M
Shared
0.00
None
0.00
BICARA THERAPEUTICS INC
SOLEShares550.41K
TypeSH
Market value$16.34M
2.26%
Sole
550.41K
Shared
0.00
None
0.00
CAREDX INC
SOLEShares531.87K
TypeSH
Market value$15.16M
2.09%
Sole
531.87K
Shared
0.00
None
0.00
CELLDEX THERAPEUTICS INC
SOLEShares399.86K
TypeSH
Market value$14.88M
2.06%
Sole
399.86K
Shared
0.00
None
0.00
COMPASS THERAPEUTICS INC
SOLEShares5.83M
TypeSH
Market value$12.77M
1.76%
Sole
5.83M
Shared
0.00
None
0.00
ALKERMES PLC
SOLEShares242.56K
TypeSH
Market value$12.71M
1.76%
Sole
242.56K
Shared
0.00
None
0.00
FIRST TRACKS BIOTHERAPEUTICS
SOLEShares603.49K
TypeSH
Market value$12.14M
1.68%
Sole
603.49K
Shared
0.00
None
0.00
PROTHENA CORP PLC
SOLEShares1.14M
TypeSH
Market value$11.19M
1.55%
Sole
1.14M
Shared
0.00
None
0.00
TRAVERE THERAPEUTICS INC
SOLEShares167.53K
TypeSH
Market value$9.52M
1.32%
Sole
167.53K
Shared
0.00
None
0.00
TAYSHA GENE THERAPIES INC
SOLEShares1.39M
TypeSH
Market value$9.48M
1.31%
Sole
1.39M
Shared
0.00
None
0.00
ACLARIS THERAPEUTICS INC
SOLEShares1.61M
TypeSH
Market value$8.54M
1.18%
Sole
1.61M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
PTC THERAPEUTICS INCSOLE | COM | 918.85K | SH | $74.95M 10.36% | 918.85K | 0.00 | 0.00 |
ACADIA PHARMACEUTICALS INCSOLE | COM | 2.86M | SH | $72.46M 10.01% | 2.86M | 0.00 | 0.00 |
INSMED INCSOLE | COM PAR $.01 | 413.98K | SH | $44.14M 6.10% | 413.98K | 0.00 | 0.00 |
MIRUM PHARMACEUTICALS INCSOLE | NOTE 4.000% 5/0 | 348.81K | PRN | $40.83M 5.64% | 348.81K | 0.00 | 0.00 |
ANAPTYSBIO INCSOLE | COM | 603.49K | SH | $40.74M 5.63% | 603.49K | 0.00 | 0.00 |
BIOMARIN PHARMACEUTICAL INCSOLE | COM | 682.78K | SH | $39.07M 5.40% | 682.78K | 0.00 | 0.00 |
DYNE THERAPEUTICS INCSOLE | COM | 1.65M | SH | $36.59M 5.06% | 1.65M | 0.00 | 0.00 |
UNITED THERAPEUTICS CORPSOLE | COM | 62.59K | SH | $33.91M 4.69% | 62.59K | 0.00 | 0.00 |
DISC MEDICINE INCSOLE | COM | 416.65K | SH | $30.47M 4.21% | 416.65K | 0.00 | 0.00 |
BIOGEN INCSOLE | COM | 140.28K | SH | $30.31M 4.19% | 140.28K | 0.00 | 0.00 |
IOVANCE BIOTHERAPEUTICS INCSOLE | COM | 5.30M | SH | $22.03M 3.04% | 5.30M | 0.00 | 0.00 |
ULTRAGENYX PHARMACEUTICAL INSOLE | COM | 596.50K | SH | $19.92M 2.75% | 596.50K | 0.00 | 0.00 |
NOVOCURE LTDSOLE | ORD SHS | 1.28M | SH | $19.40M 2.68% | 1.28M | 0.00 | 0.00 |
SYNDAX PHARMACEUTICALS INCSOLE | COM | 864.99K | SH | $18.91M 2.61% | 864.99K | 0.00 | 0.00 |
ANNEXON INCSOLE | COM | 2.95M | SH | $16.83M 2.33% | 2.95M | 0.00 | 0.00 |
BICARA THERAPEUTICS INCSOLE | COM | 550.41K | SH | $16.34M 2.26% | 550.41K | 0.00 | 0.00 |
CAREDX INCSOLE | COM | 531.87K | SH | $15.16M 2.09% | 531.87K | 0.00 | 0.00 |
CELLDEX THERAPEUTICS INCSOLE | COM NEW | 399.86K | SH | $14.88M 2.06% | 399.86K | 0.00 | 0.00 |
COMPASS THERAPEUTICS INCSOLE | COM | 5.83M | SH | $12.77M 1.76% | 5.83M | 0.00 | 0.00 |
ALKERMES PLCSOLE | SHS | 242.56K | SH | $12.71M 1.76% | 242.56K | 0.00 | 0.00 |
FIRST TRACKS BIOTHERAPEUTICSSOLE | ORD SHS | 603.49K | SH | $12.14M 1.68% | 603.49K | 0.00 | 0.00 |
PROTHENA CORP PLCSOLE | SHS | 1.14M | SH | $11.19M 1.55% | 1.14M | 0.00 | 0.00 |
TRAVERE THERAPEUTICS INCSOLE | COM | 167.53K | SH | $9.52M 1.32% | 167.53K | 0.00 | 0.00 |
TAYSHA GENE THERAPIES INCSOLE | COM SHS | 1.39M | SH | $9.48M 1.31% | 1.39M | 0.00 | 0.00 |
ACLARIS THERAPEUTICS INCSOLE | COM | 1.61M | SH | $8.54M 1.18% | 1.61M | 0.00 | 0.00 |
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