Filed: 8/14/2025ACC: 0001306923-25-000016
📋 What this filing means
PALO ALTO INVESTORS LP filed this quarterly 13F‑HR report disclosing 45 equity positions with a total reported market value of $470.00M. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
45
Positions
$470.00M
Total AUM (reported)
33.60M
Total Shares
Allocation by class
COM$375.29M79.8%
SHS$44.48M9.5%
SPONSORED ADS$28.36M6.0%
COM CL A$7.74M1.6%
COM NEW$6.52M1.4%
NAMEN AKT$2.17M0.5%
COM SHS$1.64M0.3%
Portfolio Concentration
Top 3$188.55M40.1%
4–10$165.08M35.1%
11–25$91.13M19.4%
Rest$25.23M5.4%
Top 3 weight
40.1%
Top 10 weight
75.2%
Voting Authority Distribution
Total shares with voting rights: 33.60M
Sole
Full voting authority
33.60M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole45
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings45
Rows:
INSMED INC
SOLEShares865.11K
TypeSH
Market value$87.06M
18.52%
Sole
865.11K
Shared
0.00
None
0.00
ACADIA PHARMACEUTICALS INC
SOLEShares2.56M
TypeSH
Market value$55.29M
11.76%
Sole
2.56M
Shared
0.00
None
0.00
BIOMARIN PHARMACEUTICAL INC
SOLEShares840.47K
TypeSH
Market value$46.20M
9.83%
Sole
840.47K
Shared
0.00
None
0.00
AMICUS THERAPEUTICS INC
SOLEShares5.61M
TypeSH
Market value$32.15M
6.84%
Sole
5.61M
Shared
0.00
None
0.00
UNITED THERAPEUTICS CORP
SOLEShares95.48K
TypeSH
Market value$27.44M
5.84%
Sole
95.48K
Shared
0.00
None
0.00
BIOGEN INC
SOLEShares205.76K
TypeSH
Market value$25.84M
5.50%
Sole
205.76K
Shared
0.00
None
0.00
ALNYLAM PHARMACEUTICALS INC
SOLEShares75.53K
TypeSH
Market value$24.63M
5.24%
Sole
75.53K
Shared
0.00
None
0.00
PTC THERAPEUTICS INC
SOLEShares406.47K
TypeSH
Market value$19.85M
4.22%
Sole
406.47K
Shared
0.00
None
0.00
ANAPTYSBIO INC
SOLEShares812.82K
TypeSH
Market value$18.04M
3.84%
Sole
812.82K
Shared
0.00
None
0.00
NOVOCURE LTD
SOLEShares962.40K
TypeSH
Market value$17.13M
3.64%
Sole
962.40K
Shared
0.00
None
0.00
STAAR SURGICAL CO
SOLEShares791.88K
TypeSH
Market value$13.29M
2.83%
Sole
791.88K
Shared
0.00
None
0.00
AGIOS PHARMACEUTICALS INC
SOLEShares268.78K
TypeSH
Market value$8.94M
1.90%
Sole
268.78K
Shared
0.00
None
0.00
PROTHENA CORP PLC
SOLEShares1.27M
TypeSH
Market value$7.74M
1.65%
Sole
1.27M
Shared
0.00
None
0.00
DISC MEDICINE INC
SOLEShares145.69K
TypeSH
Market value$7.72M
1.64%
Sole
145.69K
Shared
0.00
None
0.00
ALIGN TECHNOLOGY INC
SOLEShares37.77K
TypeSH
Market value$7.15M
1.52%
Sole
37.77K
Shared
0.00
None
0.00
GOSSAMER BIO INC
SOLEShares5.74M
TypeSH
Market value$7.06M
1.50%
Sole
5.74M
Shared
0.00
None
0.00
EHEALTH INC
SOLEShares1.58M
TypeSH
Market value$6.86M
1.46%
Sole
1.58M
Shared
0.00
None
0.00
ALKERMES PLC
SOLEShares221.02K
TypeSH
Market value$6.32M
1.35%
Sole
221.02K
Shared
0.00
None
0.00
IOVANCE BIOTHERAPEUTICS INC
SOLEShares3.43M
TypeSH
Market value$5.90M
1.25%
Sole
3.43M
Shared
0.00
None
0.00
SYNDAX PHARMACEUTICALS INC
SOLEShares444.37K
TypeSH
Market value$4.16M
0.89%
Sole
444.37K
Shared
0.00
None
0.00
AVIDITY BIOSCIENCES INC
SOLEShares118.89K
TypeSH
Market value$3.38M
0.72%
Sole
118.89K
Shared
0.00
None
0.00
DENALI THERAPEUTICS INC
SOLEShares239.81K
TypeSH
Market value$3.35M
0.71%
Sole
239.81K
Shared
0.00
None
0.00
MIRUM PHARMACEUTICALS INC
SOLEShares64.70K
TypeSH
Market value$3.29M
0.70%
Sole
64.70K
Shared
0.00
None
0.00
EDWARDS LIFESCIENCES CORP
SOLEShares39.47K
TypeSH
Market value$3.09M
0.66%
Sole
39.47K
Shared
0.00
None
0.00
TAYSHA GENE THERAPIES INC
SOLEShares1.25M
TypeSH
Market value$2.88M
0.61%
Sole
1.25M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
INSMED INCSOLE | COM | 865.11K | SH | $87.06M 18.52% | 865.11K | 0.00 | 0.00 |
ACADIA PHARMACEUTICALS INCSOLE | COM | 2.56M | SH | $55.29M 11.76% | 2.56M | 0.00 | 0.00 |
BIOMARIN PHARMACEUTICAL INCSOLE | COM | 840.47K | SH | $46.20M 9.83% | 840.47K | 0.00 | 0.00 |
AMICUS THERAPEUTICS INCSOLE | COM | 5.61M | SH | $32.15M 6.84% | 5.61M | 0.00 | 0.00 |
UNITED THERAPEUTICS CORPSOLE | COM | 95.48K | SH | $27.44M 5.84% | 95.48K | 0.00 | 0.00 |
BIOGEN INCSOLE | SPONSORED ADS | 205.76K | SH | $25.84M 5.50% | 205.76K | 0.00 | 0.00 |
ALNYLAM PHARMACEUTICALS INCSOLE | SHS | 75.53K | SH | $24.63M 5.24% | 75.53K | 0.00 | 0.00 |
PTC THERAPEUTICS INCSOLE | SHS | 406.47K | SH | $19.85M 4.22% | 406.47K | 0.00 | 0.00 |
ANAPTYSBIO INCSOLE | COM | 812.82K | SH | $18.04M 3.84% | 812.82K | 0.00 | 0.00 |
NOVOCURE LTDSOLE | COM | 962.40K | SH | $17.13M 3.64% | 962.40K | 0.00 | 0.00 |
STAAR SURGICAL COSOLE | COM | 791.88K | SH | $13.29M 2.83% | 791.88K | 0.00 | 0.00 |
AGIOS PHARMACEUTICALS INCSOLE | COM | 268.78K | SH | $8.94M 1.90% | 268.78K | 0.00 | 0.00 |
PROTHENA CORP PLCSOLE | COM CL A | 1.27M | SH | $7.74M 1.65% | 1.27M | 0.00 | 0.00 |
DISC MEDICINE INCSOLE | COM | 145.69K | SH | $7.72M 1.64% | 145.69K | 0.00 | 0.00 |
ALIGN TECHNOLOGY INCSOLE | COM | 37.77K | SH | $7.15M 1.52% | 37.77K | 0.00 | 0.00 |
GOSSAMER BIO INCSOLE | COM | 5.74M | SH | $7.06M 1.50% | 5.74M | 0.00 | 0.00 |
EHEALTH INCSOLE | COM | 1.58M | SH | $6.86M 1.46% | 1.58M | 0.00 | 0.00 |
ALKERMES PLCSOLE | COM | 221.02K | SH | $6.32M 1.35% | 221.02K | 0.00 | 0.00 |
IOVANCE BIOTHERAPEUTICS INCSOLE | COM NEW | 3.43M | SH | $5.90M 1.25% | 3.43M | 0.00 | 0.00 |
SYNDAX PHARMACEUTICALS INCSOLE | COM | 444.37K | SH | $4.16M 0.89% | 444.37K | 0.00 | 0.00 |
AVIDITY BIOSCIENCES INCSOLE | COM | 118.89K | SH | $3.38M 0.72% | 118.89K | 0.00 | 0.00 |
DENALI THERAPEUTICS INCSOLE | COM | 239.81K | SH | $3.35M 0.71% | 239.81K | 0.00 | 0.00 |
MIRUM PHARMACEUTICALS INCSOLE | COM | 64.70K | SH | $3.29M 0.70% | 64.70K | 0.00 | 0.00 |
EDWARDS LIFESCIENCES CORPSOLE | COM | 39.47K | SH | $3.09M 0.66% | 39.47K | 0.00 | 0.00 |
TAYSHA GENE THERAPIES INCSOLE | COM | 1.25M | SH | $2.88M 0.61% | 1.25M | 0.00 | 0.00 |
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