Filed: 5/15/2025ACC: 0001306923-25-000014
📋 What this filing means
PALO ALTO INVESTORS LP filed this quarterly 13F‑HR report disclosing 44 equity positions with a total reported market value of $525.15M. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
44
Positions
$525.15M
Total AUM (reported)
38.63M
Total Shares
Allocation by class
COM$385.22M73.4%
COM PAR $.01$75.31M14.3%
SHS$27.85M5.3%
ORD SHS$17.86M3.4%
COM PAR $0.01$9.26M1.8%
SPONSORED ADS$4.41M0.8%
COM SHS$1.97M0.4%
Portfolio Concentration
Top 3$205.31M39.1%
4–10$187.38M35.7%
11–25$112.58M21.4%
Rest$19.87M3.8%
Top 3 weight
39.1%
Top 10 weight
74.8%
Voting Authority Distribution
Total shares with voting rights: 38.63M
Sole
Full voting authority
38.63M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole44
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings44
Rows:
INSMED INC
SOLEShares987.15K
TypeSH
Market value$75.31M
14.34%
Sole
987.15K
Shared
0.00
None
0.00
BIOMARIN PHARMACEUTICAL INC
SOLEShares991.21K
TypeSH
Market value$70.07M
13.34%
Sole
991.21K
Shared
0.00
None
0.00
AMICUS THERAPEUTICS INC
SOLEShares7.35M
TypeSH
Market value$59.94M
11.41%
Sole
7.35M
Shared
0.00
None
0.00
ACADIA PHARMACEUTICALS INC
SOLEShares2.66M
TypeSH
Market value$44.25M
8.43%
Sole
2.66M
Shared
0.00
None
0.00
UNITED THERAPEUTICS CORP
SOLEShares105.23K
TypeSH
Market value$32.44M
6.18%
Sole
105.23K
Shared
0.00
None
0.00
BIOGEN INC
SOLEShares204.92K
TypeSH
Market value$28.04M
5.34%
Sole
204.92K
Shared
0.00
None
0.00
ALNYLAM PHARMACEUTICALS INC
SOLEShares83.49K
TypeSH
Market value$22.54M
4.29%
Sole
83.49K
Shared
0.00
None
0.00
PTC THERAPEUTICS INC
SOLEShares404.20K
TypeSH
Market value$20.60M
3.92%
Sole
404.20K
Shared
0.00
None
0.00
PROTHENA CORP PLC
SOLEShares1.66M
TypeSH
Market value$20.54M
3.91%
Sole
1.66M
Shared
0.00
None
0.00
ANAPTYSBIO INC
SOLEShares1.02M
TypeSH
Market value$18.98M
3.61%
Sole
1.02M
Shared
0.00
None
0.00
NOVOCURE LTD
SOLEShares1M
TypeSH
Market value$17.86M
3.40%
Sole
1M
Shared
0.00
None
0.00
SAREPTA THERAPEUTICS INC
SOLEShares210.26K
TypeSH
Market value$13.42M
2.56%
Sole
210.26K
Shared
0.00
None
0.00
EHEALTH INC
SOLEShares1.68M
TypeSH
Market value$11.25M
2.14%
Sole
1.68M
Shared
0.00
None
0.00
IOVANCE BIOTHERAPEUTICS INC
SOLEShares3.21M
TypeSH
Market value$10.69M
2.04%
Sole
3.21M
Shared
0.00
None
0.00
STAAR SURGICAL CO
SOLEShares525.02K
TypeSH
Market value$9.26M
1.76%
Sole
525.02K
Shared
0.00
None
0.00
AGIOS PHARMACEUTICALS INC
SOLEShares276.58K
TypeSH
Market value$8.10M
1.54%
Sole
276.58K
Shared
0.00
None
0.00
ALKERMES PLC
SOLEShares221.51K
TypeSH
Market value$7.31M
1.39%
Sole
221.51K
Shared
0.00
None
0.00
GOSSAMER BIO INC
SOLEShares6.28M
TypeSH
Market value$6.90M
1.31%
Sole
6.28M
Shared
0.00
None
0.00
ALIGN TECHNOLOGY INC
SOLEShares37.77K
TypeSH
Market value$6.00M
1.14%
Sole
37.77K
Shared
0.00
None
0.00
SYNDAX PHARMACEUTICALS INC
SOLEShares444.37K
TypeSH
Market value$5.46M
1.04%
Sole
444.37K
Shared
0.00
None
0.00
ACELYRIN INC
SOLEShares1.79M
TypeSH
Market value$4.43M
0.84%
Sole
1.79M
Shared
0.00
None
0.00
DYNE THERAPEUTICS INC
SOLEShares333.39K
TypeSH
Market value$3.49M
0.66%
Sole
333.39K
Shared
0.00
None
0.00
MIRUM PHARMACEUTICALS INC
SOLEShares64.70K
TypeSH
Market value$2.91M
0.56%
Sole
64.70K
Shared
0.00
None
0.00
EDWARDS LIFESCIENCES CORP
SOLEShares39.47K
TypeSH
Market value$2.86M
0.54%
Sole
39.47K
Shared
0.00
None
0.00
VERVE THERAPEUTICS INC
SOLEShares575.82K
TypeSH
Market value$2.63M
0.50%
Sole
575.82K
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
INSMED INCSOLE | COM PAR $.01 | 987.15K | SH | $75.31M 14.34% | 987.15K | 0.00 | 0.00 |
BIOMARIN PHARMACEUTICAL INCSOLE | COM | 991.21K | SH | $70.07M 13.34% | 991.21K | 0.00 | 0.00 |
AMICUS THERAPEUTICS INCSOLE | COM | 7.35M | SH | $59.94M 11.41% | 7.35M | 0.00 | 0.00 |
ACADIA PHARMACEUTICALS INCSOLE | COM | 2.66M | SH | $44.25M 8.43% | 2.66M | 0.00 | 0.00 |
UNITED THERAPEUTICS CORPSOLE | COM | 105.23K | SH | $32.44M 6.18% | 105.23K | 0.00 | 0.00 |
BIOGEN INCSOLE | COM | 204.92K | SH | $28.04M 5.34% | 204.92K | 0.00 | 0.00 |
ALNYLAM PHARMACEUTICALS INCSOLE | COM | 83.49K | SH | $22.54M 4.29% | 83.49K | 0.00 | 0.00 |
PTC THERAPEUTICS INCSOLE | COM | 404.20K | SH | $20.60M 3.92% | 404.20K | 0.00 | 0.00 |
PROTHENA CORP PLCSOLE | SHS | 1.66M | SH | $20.54M 3.91% | 1.66M | 0.00 | 0.00 |
ANAPTYSBIO INCSOLE | COM | 1.02M | SH | $18.98M 3.61% | 1.02M | 0.00 | 0.00 |
NOVOCURE LTDSOLE | ORD SHS | 1M | SH | $17.86M 3.40% | 1M | 0.00 | 0.00 |
SAREPTA THERAPEUTICS INCSOLE | COM | 210.26K | SH | $13.42M 2.56% | 210.26K | 0.00 | 0.00 |
EHEALTH INCSOLE | COM | 1.68M | SH | $11.25M 2.14% | 1.68M | 0.00 | 0.00 |
IOVANCE BIOTHERAPEUTICS INCSOLE | COM | 3.21M | SH | $10.69M 2.04% | 3.21M | 0.00 | 0.00 |
STAAR SURGICAL COSOLE | COM PAR $0.01 | 525.02K | SH | $9.26M 1.76% | 525.02K | 0.00 | 0.00 |
AGIOS PHARMACEUTICALS INCSOLE | COM | 276.58K | SH | $8.10M 1.54% | 276.58K | 0.00 | 0.00 |
ALKERMES PLCSOLE | SHS | 221.51K | SH | $7.31M 1.39% | 221.51K | 0.00 | 0.00 |
GOSSAMER BIO INCSOLE | COM | 6.28M | SH | $6.90M 1.31% | 6.28M | 0.00 | 0.00 |
ALIGN TECHNOLOGY INCSOLE | COM | 37.77K | SH | $6.00M 1.14% | 37.77K | 0.00 | 0.00 |
SYNDAX PHARMACEUTICALS INCSOLE | COM | 444.37K | SH | $5.46M 1.04% | 444.37K | 0.00 | 0.00 |
ACELYRIN INCSOLE | COM | 1.79M | SH | $4.43M 0.84% | 1.79M | 0.00 | 0.00 |
DYNE THERAPEUTICS INCSOLE | COM | 333.39K | SH | $3.49M 0.66% | 333.39K | 0.00 | 0.00 |
MIRUM PHARMACEUTICALS INCSOLE | COM | 64.70K | SH | $2.91M 0.56% | 64.70K | 0.00 | 0.00 |
EDWARDS LIFESCIENCES CORPSOLE | COM | 39.47K | SH | $2.86M 0.54% | 39.47K | 0.00 | 0.00 |
VERVE THERAPEUTICS INCSOLE | COM | 575.82K | SH | $2.63M 0.50% | 575.82K | 0.00 | 0.00 |
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