Filed: 2/14/2025ACC: 0001306923-25-000010
📋 What this filing means
PALO ALTO INVESTORS LP filed this quarterly 13F‑HR report disclosing 43 equity positions with a total reported market value of $645.38M. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
43
Positions
$645.38M
Total AUM (reported)
43.46M
Total Shares
Allocation by class
COM$452.77M70.2%
COM PAR $.01$110.70M17.2%
SHS$32.39M5.0%
ORD SHS$24.26M3.8%
COM PAR $0.01$12.16M1.9%
SPONSORED ADS$6.36M1.0%
COM CL A$2.06M0.3%
Portfolio Concentration
Top 3$253.04M39.2%
4–10$241.46M37.4%
11–25$129.65M20.1%
Rest$21.23M3.3%
Top 3 weight
39.2%
Top 10 weight
76.6%
Voting Authority Distribution
Total shares with voting rights: 43.46M
Sole
Full voting authority
43.46M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole43
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings43
Rows:
INSMED INC
SOLEShares1.60M
TypeSH
Market value$110.70M
17.15%
Sole
1.60M
Shared
0.00
None
0.00
AMICUS THERAPEUTICS INC
SOLEShares7.66M
TypeSH
Market value$72.18M
11.18%
Sole
7.66M
Shared
0.00
None
0.00
BIOMARIN PHARMACEUTICAL INC
SOLEShares1.07M
TypeSH
Market value$70.15M
10.87%
Sole
1.07M
Shared
0.00
None
0.00
UNITED THERAPEUTICS CORP
SOLEShares155.71K
TypeSH
Market value$54.94M
8.51%
Sole
155.71K
Shared
0.00
None
0.00
ACADIA PHARMACEUTICALS INC
SOLEShares2.75M
TypeSH
Market value$50.44M
7.82%
Sole
2.75M
Shared
0.00
None
0.00
ALNYLAM PHARMACEUTICALS INC
SOLEShares140.68K
TypeSH
Market value$33.10M
5.13%
Sole
140.68K
Shared
0.00
None
0.00
BIOGEN INC
SOLEShares190.15K
TypeSH
Market value$29.08M
4.51%
Sole
190.15K
Shared
0.00
None
0.00
SAREPTA THERAPEUTICS INC
SOLEShares210.26K
TypeSH
Market value$25.57M
3.96%
Sole
210.26K
Shared
0.00
None
0.00
NOVOCURE LTD
SOLEShares814.19K
TypeSH
Market value$24.26M
3.76%
Sole
814.19K
Shared
0.00
None
0.00
PROTHENA CORP PLC
SOLEShares1.74M
TypeSH
Market value$24.07M
3.73%
Sole
1.74M
Shared
0.00
None
0.00
IOVANCE BIOTHERAPEUTICS INC
SOLEShares3.04M
TypeSH
Market value$22.51M
3.49%
Sole
3.04M
Shared
0.00
None
0.00
EHEALTH INC
SOLEShares1.88M
TypeSH
Market value$17.65M
2.74%
Sole
1.88M
Shared
0.00
None
0.00
PTC THERAPEUTICS INC
SOLEShares386.41K
TypeSH
Market value$17.44M
2.70%
Sole
386.41K
Shared
0.00
None
0.00
STAAR SURGICAL CO
SOLEShares500.77K
TypeSH
Market value$12.16M
1.88%
Sole
500.77K
Shared
0.00
None
0.00
ANAPTYSBIO INC
SOLEShares843.97K
TypeSH
Market value$11.17M
1.73%
Sole
843.97K
Shared
0.00
None
0.00
ALKERMES PLC
SOLEShares289.31K
TypeSH
Market value$8.32M
1.29%
Sole
289.31K
Shared
0.00
None
0.00
ALIGN TECHNOLOGY INC
SOLEShares37.77K
TypeSH
Market value$7.88M
1.22%
Sole
37.77K
Shared
0.00
None
0.00
GOSSAMER BIO INC
SOLEShares6.28M
TypeSH
Market value$5.68M
0.88%
Sole
6.28M
Shared
0.00
None
0.00
ACELYRIN INC
SOLEShares1.79M
TypeSH
Market value$5.63M
0.87%
Sole
1.79M
Shared
0.00
None
0.00
SYNDAX PHARMACEUTICALS INC
SOLEShares405.19K
TypeSH
Market value$5.36M
0.83%
Sole
405.19K
Shared
0.00
None
0.00
BICYCLE THERAPEUTICS PLC-ADR
SOLEShares248.93K
TypeSH
Market value$3.49M
0.54%
Sole
248.93K
Shared
0.00
None
0.00
KARYOPHARM THERAPEUTICS INC
SOLEShares4.91M
TypeSH
Market value$3.32M
0.51%
Sole
4.91M
Shared
0.00
None
0.00
VERVE THERAPEUTICS INC
SOLEShares575.82K
TypeSH
Market value$3.25M
0.50%
Sole
575.82K
Shared
0.00
None
0.00
EDWARDS LIFESCIENCES CORP
SOLEShares39.47K
TypeSH
Market value$2.92M
0.45%
Sole
39.47K
Shared
0.00
None
0.00
BIONTECH SE-ADR
SOLEShares25.21K
TypeSH
Market value$2.87M
0.45%
Sole
25.21K
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
INSMED INCSOLE | COM PAR $.01 | 1.60M | SH | $110.70M 17.15% | 1.60M | 0.00 | 0.00 |
AMICUS THERAPEUTICS INCSOLE | COM | 7.66M | SH | $72.18M 11.18% | 7.66M | 0.00 | 0.00 |
BIOMARIN PHARMACEUTICAL INCSOLE | COM | 1.07M | SH | $70.15M 10.87% | 1.07M | 0.00 | 0.00 |
UNITED THERAPEUTICS CORPSOLE | COM | 155.71K | SH | $54.94M 8.51% | 155.71K | 0.00 | 0.00 |
ACADIA PHARMACEUTICALS INCSOLE | COM | 2.75M | SH | $50.44M 7.82% | 2.75M | 0.00 | 0.00 |
ALNYLAM PHARMACEUTICALS INCSOLE | COM | 140.68K | SH | $33.10M 5.13% | 140.68K | 0.00 | 0.00 |
BIOGEN INCSOLE | COM | 190.15K | SH | $29.08M 4.51% | 190.15K | 0.00 | 0.00 |
SAREPTA THERAPEUTICS INCSOLE | COM | 210.26K | SH | $25.57M 3.96% | 210.26K | 0.00 | 0.00 |
NOVOCURE LTDSOLE | ORD SHS | 814.19K | SH | $24.26M 3.76% | 814.19K | 0.00 | 0.00 |
PROTHENA CORP PLCSOLE | SHS | 1.74M | SH | $24.07M 3.73% | 1.74M | 0.00 | 0.00 |
IOVANCE BIOTHERAPEUTICS INCSOLE | COM | 3.04M | SH | $22.51M 3.49% | 3.04M | 0.00 | 0.00 |
EHEALTH INCSOLE | COM | 1.88M | SH | $17.65M 2.74% | 1.88M | 0.00 | 0.00 |
PTC THERAPEUTICS INCSOLE | COM | 386.41K | SH | $17.44M 2.70% | 386.41K | 0.00 | 0.00 |
STAAR SURGICAL COSOLE | COM PAR $0.01 | 500.77K | SH | $12.16M 1.88% | 500.77K | 0.00 | 0.00 |
ANAPTYSBIO INCSOLE | COM | 843.97K | SH | $11.17M 1.73% | 843.97K | 0.00 | 0.00 |
ALKERMES PLCSOLE | SHS | 289.31K | SH | $8.32M 1.29% | 289.31K | 0.00 | 0.00 |
ALIGN TECHNOLOGY INCSOLE | COM | 37.77K | SH | $7.88M 1.22% | 37.77K | 0.00 | 0.00 |
GOSSAMER BIO INCSOLE | COM | 6.28M | SH | $5.68M 0.88% | 6.28M | 0.00 | 0.00 |
ACELYRIN INCSOLE | COM | 1.79M | SH | $5.63M 0.87% | 1.79M | 0.00 | 0.00 |
SYNDAX PHARMACEUTICALS INCSOLE | COM | 405.19K | SH | $5.36M 0.83% | 405.19K | 0.00 | 0.00 |
BICYCLE THERAPEUTICS PLC-ADRSOLE | SPONSORED ADS | 248.93K | SH | $3.49M 0.54% | 248.93K | 0.00 | 0.00 |
KARYOPHARM THERAPEUTICS INCSOLE | COM | 4.91M | SH | $3.32M 0.51% | 4.91M | 0.00 | 0.00 |
VERVE THERAPEUTICS INCSOLE | COM | 575.82K | SH | $3.25M 0.50% | 575.82K | 0.00 | 0.00 |
EDWARDS LIFESCIENCES CORPSOLE | COM | 39.47K | SH | $2.92M 0.45% | 39.47K | 0.00 | 0.00 |
BIONTECH SE-ADRSOLE | SPONSORED ADS | 25.21K | SH | $2.87M 0.45% | 25.21K | 0.00 | 0.00 |
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