Filed: 2/17/2026ACC: 0001172661-26-001119
📋 What this filing means
ORBIMED ADVISORS LLC filed this quarterly 13F‑HR report disclosing 105 equity positions with a total reported market value of $4.90B. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
105
Positions
$4.90B
Total AUM (reported)
213.46M
Total Shares
Allocation by class
COM$3.87B79.0%
COM NEW$410.35M8.4%
SHS$270.21M5.5%
SPONSORED ADR$159.45M3.3%
SPONSORED ADS$130.42M2.7%
NONVOTING$20.13M0.4%
CL A$17.90M0.4%
Portfolio Concentration
Top 3$939.47M19.2%
4–10$1.05B21.5%
11–25$1.26B25.7%
Rest$1.65B33.6%
Top 3 weight
19.2%
Top 10 weight
40.6%
Voting Authority Distribution
Total shares with voting rights: 213.46M
Sole
Full voting authority
155.22M
shares
% of voting shares72.7%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
58.24M
shares
% of voting shares27.3%
Investment Discretion (by position count)
Sole53
Shared0
Other52
Dominant voting typeSole · 72.7% of voting shares
Institutional Holdings105
Rows:
EDGEWISE THERAPEUTICS INC
DFNDShares15.52M
TypeSH
Market value$385.09M
7.86%
Sole
15.25M
Shared
0.00
None
265.63K
ELI LILLY & CO
SOLEShares301.20K
TypeSH
Market value$323.69M
6.61%
Sole
0.00
Shared
0.00
None
301.20K
BOSTON SCIENTIFIC CORP
SOLEShares2.42M
TypeSH
Market value$230.68M
4.71%
Sole
0.00
Shared
0.00
None
2.42M
SINOVAC BIOTECH LTD
SOLEShares2.72M
TypeSH
Market value$184.47M
3.77%
Sole
0.00
Shared
0.00
None
2.72M
EDWARDS LIFESCIENCES CORP
SOLEShares1.99M
TypeSH
Market value$169.89M
3.47%
Sole
87.50K
Shared
0.00
None
1.91M
UPSTREAM BIO INC
SOLEShares5.69M
TypeSH
Market value$154.58M
3.16%
Sole
5.69M
Shared
0.00
None
0.00
INTUITIVE SURGICAL INC
SOLEShares263.40K
TypeSH
Market value$149.18M
3.04%
Sole
0.00
Shared
0.00
None
263.40K
SIONNA THERAPEUTICS INC
SOLEShares3.56M
TypeSH
Market value$146.53M
2.99%
Sole
3.56M
Shared
0.00
None
0.00
MBX BIOSCIENCES INC
SOLEShares3.94M
TypeSH
Market value$124.12M
2.53%
Sole
3.94M
Shared
0.00
None
0.00
ARGENX SE
DFNDShares146K
TypeSH
Market value$122.78M
2.51%
Sole
27.70K
Shared
0.00
None
118.30K
ENLIVEN THERAPEUTICS INC
DFNDShares7.96M
TypeSH
Market value$122.58M
2.50%
Sole
7.92M
Shared
0.00
None
41.38K
ALNYLAM PHARMACEUTICALS INC
DFNDShares288.80K
TypeSH
Market value$114.84M
2.34%
Sole
58K
Shared
0.00
None
230.80K
STRYKER CORPORATION
SOLEShares325K
TypeSH
Market value$114.23M
2.33%
Sole
0.00
Shared
0.00
None
325K
ARS PHARMACEUTICALS INC
SOLEShares8.29M
TypeSH
Market value$96.56M
1.97%
Sole
8.29M
Shared
0.00
None
0.00
TERNS PHARMACEUTICALS INC
SOLEShares2.15M
TypeSH
Market value$86.99M
1.78%
Sole
2.15M
Shared
0.00
None
0.00
DISC MEDICINE INC
SOLEShares1.07M
TypeSH
Market value$84.77M
1.73%
Sole
1.07M
Shared
0.00
None
0.00
CARIS LIFE SCIENCES INC
DFNDShares3.12M
TypeSH
Market value$84.07M
1.72%
Sole
437.65K
Shared
0.00
None
2.68M
NATERA INC
DFNDShares365.80K
TypeSH
Market value$83.80M
1.71%
Sole
56K
Shared
0.00
None
309.80K
COMPASS THERAPEUTICS INC
SOLEShares15.22M
TypeSH
Market value$81.73M
1.67%
Sole
15.22M
Shared
0.00
None
0.00
STRUCTURE THERAPEUTICS INC
DFNDShares1.16M
TypeSH
Market value$80.80M
1.65%
Sole
292.30K
Shared
0.00
None
869.50K
DANAHER CORPORATION
SOLEShares299.80K
TypeSH
Market value$68.63M
1.40%
Sole
0.00
Shared
0.00
None
299.80K
CG ONCOLOGY INC
DFNDShares1.52M
TypeSH
Market value$62.97M
1.29%
Sole
293.10K
Shared
0.00
None
1.22M
APELLIS PHARMACEUTICALS INC
DFNDShares2.43M
TypeSH
Market value$61.04M
1.25%
Sole
326.13K
Shared
0.00
None
2.10M
ARRIVENT BIOPHARMA INC
SOLEShares3.03M
TypeSH
Market value$60.91M
1.24%
Sole
3.03M
Shared
0.00
None
0.00
THE CIGNA GROUP
SOLEShares205K
TypeSH
Market value$56.42M
1.15%
Sole
0.00
Shared
0.00
None
205K
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
EDGEWISE THERAPEUTICS INCDFND | COM | 15.52M | SH | $385.09M 7.86% | 15.25M | 0.00 | 265.63K |
ELI LILLY & COSOLE | COM | 301.20K | SH | $323.69M 6.61% | 0.00 | 0.00 | 301.20K |
BOSTON SCIENTIFIC CORPSOLE | COM | 2.42M | SH | $230.68M 4.71% | 0.00 | 0.00 | 2.42M |
SINOVAC BIOTECH LTDSOLE | SHS | 2.72M | SH | $184.47M 3.77% | 0.00 | 0.00 | 2.72M |
EDWARDS LIFESCIENCES CORPSOLE | COM | 1.99M | SH | $169.89M 3.47% | 87.50K | 0.00 | 1.91M |
UPSTREAM BIO INCSOLE | COM | 5.69M | SH | $154.58M 3.16% | 5.69M | 0.00 | 0.00 |
INTUITIVE SURGICAL INCSOLE | COM NEW | 263.40K | SH | $149.18M 3.04% | 0.00 | 0.00 | 263.40K |
SIONNA THERAPEUTICS INCSOLE | COM | 3.56M | SH | $146.53M 2.99% | 3.56M | 0.00 | 0.00 |
MBX BIOSCIENCES INCSOLE | COM | 3.94M | SH | $124.12M 2.53% | 3.94M | 0.00 | 0.00 |
ARGENX SEDFND | SPONSORED ADR | 146K | SH | $122.78M 2.51% | 27.70K | 0.00 | 118.30K |
ENLIVEN THERAPEUTICS INCDFND | COM | 7.96M | SH | $122.58M 2.50% | 7.92M | 0.00 | 41.38K |
ALNYLAM PHARMACEUTICALS INCDFND | COM | 288.80K | SH | $114.84M 2.34% | 58K | 0.00 | 230.80K |
STRYKER CORPORATIONSOLE | COM | 325K | SH | $114.23M 2.33% | 0.00 | 0.00 | 325K |
ARS PHARMACEUTICALS INCSOLE | COM | 8.29M | SH | $96.56M 1.97% | 8.29M | 0.00 | 0.00 |
TERNS PHARMACEUTICALS INCSOLE | COM | 2.15M | SH | $86.99M 1.78% | 2.15M | 0.00 | 0.00 |
DISC MEDICINE INCSOLE | COM | 1.07M | SH | $84.77M 1.73% | 1.07M | 0.00 | 0.00 |
CARIS LIFE SCIENCES INCDFND | COM | 3.12M | SH | $84.07M 1.72% | 437.65K | 0.00 | 2.68M |
NATERA INCDFND | COM | 365.80K | SH | $83.80M 1.71% | 56K | 0.00 | 309.80K |
COMPASS THERAPEUTICS INCSOLE | COM | 15.22M | SH | $81.73M 1.67% | 15.22M | 0.00 | 0.00 |
STRUCTURE THERAPEUTICS INCDFND | SPONSORED ADS | 1.16M | SH | $80.80M 1.65% | 292.30K | 0.00 | 869.50K |
DANAHER CORPORATIONSOLE | COM | 299.80K | SH | $68.63M 1.40% | 0.00 | 0.00 | 299.80K |
CG ONCOLOGY INCDFND | COM | 1.52M | SH | $62.97M 1.29% | 293.10K | 0.00 | 1.22M |
APELLIS PHARMACEUTICALS INCDFND | COM | 2.43M | SH | $61.04M 1.25% | 326.13K | 0.00 | 2.10M |
ARRIVENT BIOPHARMA INCSOLE | COM | 3.03M | SH | $60.91M 1.24% | 3.03M | 0.00 | 0.00 |
THE CIGNA GROUPSOLE | COM | 205K | SH | $56.42M 1.15% | 0.00 | 0.00 | 205K |
Page 1 of 5
…