Filed: 11/14/2025ACC: 0001172661-25-005047
📋 What this filing means
ORBIMED ADVISORS LLC filed this quarterly 13F‑HR report disclosing 104 equity positions with a total reported market value of $4.26B. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
104
Positions
$4.26B
Total AUM (reported)
240.27M
Total Shares
Allocation by class
COM$3.45B81.1%
SHS$281.74M6.6%
COM NEW$251.92M5.9%
SPONSORED ADR$176.74M4.2%
SPONSORED ADS$64.16M1.5%
NONVOTING$12.50M0.3%
COM STK$11.62M0.3%
Portfolio Concentration
Top 3$738.22M17.3%
4–10$1.00B23.6%
11–25$1.11B26.1%
Rest$1.40B33.0%
Top 3 weight
17.3%
Top 10 weight
40.9%
Voting Authority Distribution
Total shares with voting rights: 240.27M
Sole
Full voting authority
183.20M
shares
% of voting shares76.2%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
57.07M
shares
% of voting shares23.8%
Investment Discretion (by position count)
Sole49
Shared0
Other55
Dominant voting typeSole · 76.2% of voting shares
Institutional Holdings104
Rows:
BOSTON SCIENTIFIC CORP
SOLEShares2.63M
TypeSH
Market value$256.70M
6.03%
Sole
106K
Shared
0.00
None
2.52M
EDGEWISE THERAPEUTICS INC
DFNDShares15.52M
TypeSH
Market value$251.71M
5.92%
Sole
15.25M
Shared
0.00
None
265.63K
ELI LILLY & CO
SOLEShares301.20K
TypeSH
Market value$229.82M
5.40%
Sole
0.00
Shared
0.00
None
301.20K
SINOVAC BIOTECH LTD
SOLEShares2.72M
TypeSH
Market value$184.47M
4.33%
Sole
0.00
Shared
0.00
None
2.72M
ENLIVEN THERAPEUTICS INC
DFNDShares7.96M
TypeSH
Market value$162.93M
3.83%
Sole
7.92M
Shared
0.00
None
41.38K
ALNYLAM PHARMACEUTICALS INC
DFNDShares301.60K
TypeSH
Market value$137.53M
3.23%
Sole
58K
Shared
0.00
None
243.60K
STRYKER CORPORATION
SOLEShares359.20K
TypeSH
Market value$132.79M
3.12%
Sole
0.00
Shared
0.00
None
359.20K
EDWARDS LIFESCIENCES CORP
SOLEShares1.68M
TypeSH
Market value$130.96M
3.08%
Sole
0.00
Shared
0.00
None
1.68M
INTUITIVE SURGICAL INC
SOLEShares287.20K
TypeSH
Market value$128.44M
3.02%
Sole
0.00
Shared
0.00
None
287.20K
ARGENX SE
DFNDShares172.30K
TypeSH
Market value$127.08M
2.99%
Sole
27.70K
Shared
0.00
None
144.60K
SIONNA THERAPEUTICS INC
SOLEShares3.70M
TypeSH
Market value$108.96M
2.56%
Sole
3.70M
Shared
0.00
None
0.00
UPSTREAM BIO INC
SOLEShares5.69M
TypeSH
Market value$107.10M
2.52%
Sole
5.69M
Shared
0.00
None
0.00
DISC MEDICINE INC
SOLEShares1.42M
TypeSH
Market value$93.50M
2.20%
Sole
1.42M
Shared
0.00
None
0.00
CARIS LIFE SCIENCES INC
DFNDShares3.03M
TypeSH
Market value$91.80M
2.16%
Sole
226.45K
Shared
0.00
None
2.81M
ARS PHARMACEUTICALS INC
SOLEShares8.29M
TypeSH
Market value$83.30M
1.96%
Sole
8.29M
Shared
0.00
None
0.00
AVIDITY BIOSCIENCES INC
DFNDShares1.64M
TypeSH
Market value$71.41M
1.68%
Sole
293.53K
Shared
0.00
None
1.35M
MBX BIOSCIENCES INC
SOLEShares4M
TypeSH
Market value$70.05M
1.65%
Sole
4M
Shared
0.00
None
0.00
CG ONCOLOGY INC
DFNDShares1.73M
TypeSH
Market value$69.56M
1.63%
Sole
293.10K
Shared
0.00
None
1.43M
NATERA INC
DFNDShares429.30K
TypeSH
Market value$69.10M
1.62%
Sole
56K
Shared
0.00
None
373.30K
AXSOME THERAPEUTICS INC
DFNDShares531.80K
TypeSH
Market value$64.59M
1.52%
Sole
69.60K
Shared
0.00
None
462.20K
APELLIS PHARMACEUTICALS INC
DFNDShares2.57M
TypeSH
Market value$58.24M
1.37%
Sole
455.53K
Shared
0.00
None
2.12M
TERNS PHARMACEUTICALS INC
SOLEShares7.56M
TypeSH
Market value$56.80M
1.33%
Sole
7.56M
Shared
0.00
None
0.00
ARRIVENT BIOPHARMA INC
SOLEShares3.03M
TypeSH
Market value$55.85M
1.31%
Sole
3.03M
Shared
0.00
None
0.00
MINERALYS THERAPEUTICS INC
DFNDShares1.47M
TypeSH
Market value$55.72M
1.31%
Sole
648.64K
Shared
0.00
None
820.85K
EXACT SCIENCES CORP
DFNDShares994.62K
TypeSH
Market value$54.42M
1.28%
Sole
158.72K
Shared
0.00
None
835.90K
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
BOSTON SCIENTIFIC CORPSOLE | COM | 2.63M | SH | $256.70M 6.03% | 106K | 0.00 | 2.52M |
EDGEWISE THERAPEUTICS INCDFND | COM | 15.52M | SH | $251.71M 5.92% | 15.25M | 0.00 | 265.63K |
ELI LILLY & COSOLE | COM | 301.20K | SH | $229.82M 5.40% | 0.00 | 0.00 | 301.20K |
SINOVAC BIOTECH LTDSOLE | SHS | 2.72M | SH | $184.47M 4.33% | 0.00 | 0.00 | 2.72M |
ENLIVEN THERAPEUTICS INCDFND | COM | 7.96M | SH | $162.93M 3.83% | 7.92M | 0.00 | 41.38K |
ALNYLAM PHARMACEUTICALS INCDFND | COM | 301.60K | SH | $137.53M 3.23% | 58K | 0.00 | 243.60K |
STRYKER CORPORATIONSOLE | COM | 359.20K | SH | $132.79M 3.12% | 0.00 | 0.00 | 359.20K |
EDWARDS LIFESCIENCES CORPSOLE | COM | 1.68M | SH | $130.96M 3.08% | 0.00 | 0.00 | 1.68M |
INTUITIVE SURGICAL INCSOLE | COM NEW | 287.20K | SH | $128.44M 3.02% | 0.00 | 0.00 | 287.20K |
ARGENX SEDFND | SPONSORED ADR | 172.30K | SH | $127.08M 2.99% | 27.70K | 0.00 | 144.60K |
SIONNA THERAPEUTICS INCSOLE | COM | 3.70M | SH | $108.96M 2.56% | 3.70M | 0.00 | 0.00 |
UPSTREAM BIO INCSOLE | COM | 5.69M | SH | $107.10M 2.52% | 5.69M | 0.00 | 0.00 |
DISC MEDICINE INCSOLE | COM | 1.42M | SH | $93.50M 2.20% | 1.42M | 0.00 | 0.00 |
CARIS LIFE SCIENCES INCDFND | COM | 3.03M | SH | $91.80M 2.16% | 226.45K | 0.00 | 2.81M |
ARS PHARMACEUTICALS INCSOLE | COM | 8.29M | SH | $83.30M 1.96% | 8.29M | 0.00 | 0.00 |
AVIDITY BIOSCIENCES INCDFND | COM | 1.64M | SH | $71.41M 1.68% | 293.53K | 0.00 | 1.35M |
MBX BIOSCIENCES INCSOLE | COM | 4M | SH | $70.05M 1.65% | 4M | 0.00 | 0.00 |
CG ONCOLOGY INCDFND | COM | 1.73M | SH | $69.56M 1.63% | 293.10K | 0.00 | 1.43M |
NATERA INCDFND | COM | 429.30K | SH | $69.10M 1.62% | 56K | 0.00 | 373.30K |
AXSOME THERAPEUTICS INCDFND | COM | 531.80K | SH | $64.59M 1.52% | 69.60K | 0.00 | 462.20K |
APELLIS PHARMACEUTICALS INCDFND | COM | 2.57M | SH | $58.24M 1.37% | 455.53K | 0.00 | 2.12M |
TERNS PHARMACEUTICALS INCSOLE | COM | 7.56M | SH | $56.80M 1.33% | 7.56M | 0.00 | 0.00 |
ARRIVENT BIOPHARMA INCSOLE | COM | 3.03M | SH | $55.85M 1.31% | 3.03M | 0.00 | 0.00 |
MINERALYS THERAPEUTICS INCDFND | COM | 1.47M | SH | $55.72M 1.31% | 648.64K | 0.00 | 820.85K |
EXACT SCIENCES CORPDFND | COM | 994.62K | SH | $54.42M 1.28% | 158.72K | 0.00 | 835.90K |
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