Filed: 5/15/2026ACC: 0001420506-26-001151
📋 What this filing means
OPALEYE MANAGEMENT INC. filed this quarterly 13F‑HR report disclosing 54 equity positions with a total reported market value of $759.22M. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
54
Positions
$759.22M
Total AUM (reported)
57.36M
Total Shares
Allocation by class
COM$545.11M71.8%
COM NEW$168.56M22.2%
SHS NEW$39.61M5.2%
COM SHS$5.11M0.7%
CALL$834.0K0.1%
Portfolio Concentration
Top 3$259.27M34.1%
4–10$207.29M27.3%
11–25$203.25M26.8%
Rest$89.41M11.8%
Top 3 weight
34.1%
Top 10 weight
61.5%
Voting Authority Distribution
Total shares with voting rights: 57.36M
Sole
Full voting authority
57.36M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole54
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings54
Rows:
HARROW INC
SOLEShares2.83M
TypeSH
Market value$99.86M
13.15%
Sole
2.83M
Shared
0.00
None
0.00
LIQUIDIA CORPORATION
SOLEShares2.54M
TypeSH
Market value$88.82M
11.70%
Sole
2.54M
Shared
0.00
None
0.00
ETON PHARMACEUTICALS INC
SOLEShares2.86M
TypeSH
Market value$70.58M
9.30%
Sole
2.86M
Shared
0.00
None
0.00
SOL-GEL TECHNOLOGIES LTD
SOLEShares500K
TypeSH
Market value$39.61M
5.22%
Sole
500K
Shared
0.00
None
0.00
RHYTHM PHARMACEUTICALS INC
SOLEShares123K
TypeSH
Market value$35.32M
4.65%
Sole
123K
Shared
0.00
None
0.00
APOGEE THERAPEUTICS INC
SOLEShares390K
TypeSH
Market value$32.83M
4.32%
Sole
390K
Shared
0.00
None
0.00
DISC MEDICINE INC
SOLEShares421K
TypeSH
Market value$26.92M
3.55%
Sole
421K
Shared
0.00
None
0.00
UROGEN PHARMA LTD
SOLEShares1.43M
TypeSH
Market value$25.71M
3.39%
Sole
1.43M
Shared
0.00
None
0.00
CRESCENT BIOPHARMA INC.
SOLEShares1.31M
TypeSH
Market value$24.11M
3.18%
Sole
1.31M
Shared
0.00
None
0.00
STOKE THERAPEUTICS INC
SOLEShares700K
TypeSH
Market value$22.79M
3.00%
Sole
700K
Shared
0.00
None
0.00
PERSPECTIVE THERAPEUTICS INC
SOLEShares4.67M
TypeSH
Market value$19.49M
2.57%
Sole
4.67M
Shared
0.00
None
0.00
REZOLUTE INC
SOLEShares6.30M
TypeSH
Market value$19.21M
2.53%
Sole
6.30M
Shared
0.00
None
0.00
MEIRAGTX HLDGS PLC
SOLEShares2.12M
TypeSH
Market value$18.39M
2.42%
Sole
2.12M
Shared
0.00
None
0.00
TG THERAPEUTICS INC
SOLEShares535K
TypeSH
Market value$17.77M
2.34%
Sole
535K
Shared
0.00
None
0.00
SANUWAVE HEALTH INC
SOLEShares981.27K
TypeSH
Market value$16.97M
2.23%
Sole
981.27K
Shared
0.00
None
0.00
EDGEWISE THERAPEUTICS INC
SOLEShares500K
TypeSH
Market value$15.75M
2.07%
Sole
500K
Shared
0.00
None
0.00
ALPHA COGNITION INC
SOLEShares2.56M
TypeSH
Market value$14.07M
1.85%
Sole
2.56M
Shared
0.00
None
0.00
ANNEXON INC
SOLEShares2.33M
TypeSH
Market value$12.92M
1.70%
Sole
2.33M
Shared
0.00
None
0.00
ALUMIS INC
SOLEShares550K
TypeSH
Market value$12.12M
1.60%
Sole
550K
Shared
0.00
None
0.00
CODEXIS INC
SOLEShares6.79M
TypeSH
Market value$11.06M
1.46%
Sole
6.79M
Shared
0.00
None
0.00
PROTAGONIST THERAPEUTICS INC
SOLEShares100K
TypeSH
Market value$10.54M
1.39%
Sole
100K
Shared
0.00
None
0.00
REVOLUTION MEDICINES INC
SOLEShares100K
TypeSH
Market value$9.72M
1.28%
Sole
100K
Shared
0.00
None
0.00
XOMA ROYALTY CORPORATION
SOLEShares300K
TypeSH
Market value$9.41M
1.24%
Sole
300K
Shared
0.00
None
0.00
Q32 BIO INC
SOLEShares1.26M
TypeSH
Market value$8.06M
1.06%
Sole
1.26M
Shared
0.00
None
0.00
MBX BIOSCIENCES INC
SOLEShares260K
TypeSH
Market value$7.76M
1.02%
Sole
260K
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
HARROW INCSOLE | COM | 2.83M | SH | $99.86M 13.15% | 2.83M | 0.00 | 0.00 |
LIQUIDIA CORPORATIONSOLE | COM NEW | 2.54M | SH | $88.82M 11.70% | 2.54M | 0.00 | 0.00 |
ETON PHARMACEUTICALS INCSOLE | COM | 2.86M | SH | $70.58M 9.30% | 2.86M | 0.00 | 0.00 |
SOL-GEL TECHNOLOGIES LTDSOLE | SHS NEW | 500K | SH | $39.61M 5.22% | 500K | 0.00 | 0.00 |
RHYTHM PHARMACEUTICALS INCSOLE | COM | 123K | SH | $35.32M 4.65% | 123K | 0.00 | 0.00 |
APOGEE THERAPEUTICS INCSOLE | COM | 390K | SH | $32.83M 4.32% | 390K | 0.00 | 0.00 |
DISC MEDICINE INCSOLE | COM | 421K | SH | $26.92M 3.55% | 421K | 0.00 | 0.00 |
UROGEN PHARMA LTDSOLE | COM | 1.43M | SH | $25.71M 3.39% | 1.43M | 0.00 | 0.00 |
CRESCENT BIOPHARMA INC.SOLE | COM | 1.31M | SH | $24.11M 3.18% | 1.31M | 0.00 | 0.00 |
STOKE THERAPEUTICS INCSOLE | COM | 700K | SH | $22.79M 3.00% | 700K | 0.00 | 0.00 |
PERSPECTIVE THERAPEUTICS INCSOLE | COM NEW | 4.67M | SH | $19.49M 2.57% | 4.67M | 0.00 | 0.00 |
REZOLUTE INCSOLE | COM NEW | 6.30M | SH | $19.21M 2.53% | 6.30M | 0.00 | 0.00 |
MEIRAGTX HLDGS PLCSOLE | COM | 2.12M | SH | $18.39M 2.42% | 2.12M | 0.00 | 0.00 |
TG THERAPEUTICS INCSOLE | COM | 535K | SH | $17.77M 2.34% | 535K | 0.00 | 0.00 |
SANUWAVE HEALTH INCSOLE | COM | 981.27K | SH | $16.97M 2.23% | 981.27K | 0.00 | 0.00 |
EDGEWISE THERAPEUTICS INCSOLE | COM | 500K | SH | $15.75M 2.07% | 500K | 0.00 | 0.00 |
ALPHA COGNITION INCSOLE | COM NEW | 2.56M | SH | $14.07M 1.85% | 2.56M | 0.00 | 0.00 |
ANNEXON INCSOLE | COM | 2.33M | SH | $12.92M 1.70% | 2.33M | 0.00 | 0.00 |
ALUMIS INCSOLE | COM | 550K | SH | $12.12M 1.60% | 550K | 0.00 | 0.00 |
CODEXIS INCSOLE | COM | 6.79M | SH | $11.06M 1.46% | 6.79M | 0.00 | 0.00 |
PROTAGONIST THERAPEUTICS INCSOLE | COM | 100K | SH | $10.54M 1.39% | 100K | 0.00 | 0.00 |
REVOLUTION MEDICINES INCSOLE | COM | 100K | SH | $9.72M 1.28% | 100K | 0.00 | 0.00 |
XOMA ROYALTY CORPORATIONSOLE | COM NEW | 300K | SH | $9.41M 1.24% | 300K | 0.00 | 0.00 |
Q32 BIO INCSOLE | COM | 1.26M | SH | $8.06M 1.06% | 1.26M | 0.00 | 0.00 |
MBX BIOSCIENCES INCSOLE | COM | 260K | SH | $7.76M 1.02% | 260K | 0.00 | 0.00 |
Page 1 of 3