MONIA BRETT P (Chief Operating Officer) sold 39.9% of their position (160.77K shares) of IONIS PHARMACEUTICALS INC on the open market

Open‑market sale worth $12.11M — a major position exit. Review remaining holdings and any 10b5‑1 plan disclosures.

S · 5 sales

MONIA BRETT P

Filed: 3/11/2026ACC: 0000874015-26-000143

InsiderMONIA BRETT PCIK 1537529

→

IssuerIONIS PHARMACEUTICALS INCCIK 874015

Officer· Chief Operating Officer

Since Jul 2018

-160.77K

Net shares

Net seller

$12.11M

Total sold

Open market trades

0B · 5S

Total transactions

148.45K acquired · 309.23K disposed

Non-Derivative Transactions8

Common Stock

Direct

M · Option Exercise

+40.82K

Price / share

$60.89

Trade value

$2.49M

% of position

16.0%

3/9/2026

254.98K→295.80K

Common Stock

Direct

M · Option Exercise

+73.53K

Price / share

$60.89

Trade value

$4.48M

% of position

24.9%

3/9/2026

295.80K→369.33K

Common Stock

Direct

S · Sale

−7.38K

Price / share

$74.11

Trade value

$547.09K

% of position

2.0%

3/9/2026

369.33K→361.95K

Common Stock

Direct

S · Sale

−117.60K

Price / share

$75.26

Trade value

$8.85M

% of position

32.5%

3/9/2026

361.95K→244.35K

Common Stock

Direct

S · Sale

−1.68K

Price / share

$75.58

Trade value

$127.28K

% of position

0.7%

3/9/2026

244.35K→242.66K

Common Stock

Direct

M · Option Exercise

+34.10K

Price / share

$60.89

Trade value

$2.08M

% of position

14.1%

3/10/2026

242.66K→276.76K

Common Stock

Direct

S · Sale

−16.51K

Price / share

$75.47

Trade value

$1.25M

% of position

6.0%

3/10/2026

276.76K→260.25K

Common Stock

Direct

S · Sale

−17.59K

Price / share

$76.34

Trade value

$1.34M

% of position

6.8%

3/10/2026

260.25K→242.66K

Total

Net shares

−12.32K

Net value

-$3.07M

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Direct	3/9/2026	M · Option Exercise	+40.82K	$60.89	$2.49M	16.0%	254.98K	295.80K
Common Stock Direct	3/9/2026	M · Option Exercise	+73.53K	$60.89	$4.48M	24.9%	295.80K	369.33K
Common Stock Direct	3/9/2026	S · Sale	−7.38K	$74.11	$547.09K	2.0%	369.33K	361.95K
Common Stock Direct	3/9/2026	S · Sale	−117.60K	$75.26	$8.85M	32.5%	361.95K	244.35K
Common Stock Direct	3/9/2026	S · Sale	−1.68K	$75.58	$127.28K	0.7%	244.35K	242.66K
Common Stock Direct	3/10/2026	M · Option Exercise	+34.10K	$60.89	$2.08M	14.1%	242.66K	276.76K
Common Stock Direct	3/10/2026	S · Sale	−16.51K	$75.47	$1.25M	6.0%	276.76K	260.25K
Common Stock Direct	3/10/2026	S · Sale	−17.59K	$76.34	$1.34M	6.8%	260.25K	242.66K
Total			−12.32K		-$3.07M

Derivative Transactions3

Non-Qualified Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

40.82K shares

−40.82K

Strike price

60.89

Held after

107.63K

Exercisable

—

3/9/2026

Non-Qualified Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

73.53K shares

−73.53K

Strike price

60.89

Held after

34.10K

Exercisable

—

3/9/2026

Non-Qualified Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

34.10K shares

−34.10K

Strike price

60.89

Held after

0.00

Exercisable

—

3/10/2026

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Non-Qualified Stock Option (right to buy) Direct	Common Stock40.82K shares	3/9/2026	M · Option Exercise	−40.82K	60.89	—	107.63K
Non-Qualified Stock Option (right to buy) Direct	Common Stock73.53K shares	3/9/2026	M · Option Exercise	−73.53K	60.89	—	34.10K
Non-Qualified Stock Option (right to buy) Direct	Common Stock34.10K shares	3/10/2026	M · Option Exercise	−34.10K	60.89	—	0.00