MASTROCOLA LAUREN (Principal Accounting Officer) sold 56.6% of their position (13.60K shares) of PRAXIS PRECISION MEDICINES, INC. on the open market

Open‑market sale worth $2.61M — a major position exit. Review remaining holdings and any 10b5‑1 plan disclosures.

S · 2 sales

MASTROCOLA LAUREN

Filed: 11/21/2025ACC: 0001104659-25-115098

InsiderMASTROCOLA LAURENCIK 1827639

→

IssuerPRAXIS PRECISION MEDICINES, INC.CIK 1689548

Officer· Principal Accounting Officer

Since Oct 2020

-13.60K

Net shares

Net seller

$2.61M

Total sold

Open market trades

0B · 2S

Total transactions

13.60K acquired · 27.20K disposed

Non-Derivative Transactions9

Common Stock

Direct

M · Option Exercise

+1.05K

Price / share

$49.50

Trade value

$51.83K

% of position

10.0%

11/20/2025

10.44K→11.49K

Common Stock

Direct

M · Option Exercise

+508.00

Price / share

$83.85

Trade value

$42.60K

% of position

4.4%

11/20/2025

11.49K→12K

Common Stock

Direct

M · Option Exercise

+1.56K

Price / share

$133.65

Trade value

$208.09K

% of position

13.0%

11/20/2025

12K→13.55K

Common Stock

Direct

M · Option Exercise

+2.68K

Price / share

$43.37

Trade value

$116.23K

% of position

19.8%

11/20/2025

13.55K→16.23K

Common Stock

Direct

M · Option Exercise

+207.00

Price / share

$44.40

Trade value

$9.19K

% of position

1.3%

11/20/2025

16.23K→16.44K

Common Stock

Direct

M · Option Exercise

+2.35K

Price / share

$44.40

Trade value

$104.38K

% of position

14.3%

11/20/2025

16.44K→18.79K

Common Stock

Direct

M · Option Exercise

+5.25K

Price / share

$56.94

Trade value

$298.94K

% of position

27.9%

11/20/2025

18.79K→24.04K

Common Stock

Direct

S · Sale

−11.46K

Price / share

$191.96

Trade value

$2.20M

% of position

47.6%

11/20/2025

24.04K→12.59K

Common Stock

Direct

S · Sale

−2.15K

Price / share

$192.71

Trade value

$413.37K

% of position

17.0%

11/20/2025

12.59K→10.44K

Total

Net shares

+0.00

Net value

-$1.78M

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Direct	11/20/2025	M · Option Exercise	+1.05K	$49.50	$51.83K	10.0%	10.44K	11.49K
Common Stock Direct	11/20/2025	M · Option Exercise	+508.00	$83.85	$42.60K	4.4%	11.49K	12K
Common Stock Direct	11/20/2025	M · Option Exercise	+1.56K	$133.65	$208.09K	13.0%	12K	13.55K
Common Stock Direct	11/20/2025	M · Option Exercise	+2.68K	$43.37	$116.23K	19.8%	13.55K	16.23K
Common Stock Direct	11/20/2025	M · Option Exercise	+207.00	$44.40	$9.19K	1.3%	16.23K	16.44K
Common Stock Direct	11/20/2025	M · Option Exercise	+2.35K	$44.40	$104.38K	14.3%	16.44K	18.79K
Common Stock Direct	11/20/2025	M · Option Exercise	+5.25K	$56.94	$298.94K	27.9%	18.79K	24.04K
Common Stock Direct	11/20/2025	S · Sale	−11.46K	$191.96	$2.20M	47.6%	24.04K	12.59K
Common Stock Direct	11/20/2025	S · Sale	−2.15K	$192.71	$413.37K	17.0%	12.59K	10.44K
Total			+0.00		-$1.78M

Derivative Transactions7

Stock Option (Right to Buy)

Direct

M · Option Exercise

Converts to

Common Stock

1.05K shares

−1.05K

Strike price

49.50

Held after

0.00

Exercisable

—

11/20/2025

Stock Option (Right to Buy)

Direct

M · Option Exercise

Converts to

Common Stock

508.00 shares

−508.00

Strike price

83.85

Held after

0.00

Exercisable

—

11/20/2025

Stock Option (Right to Buy)

Direct

M · Option Exercise

Converts to

Common Stock

1.56K shares

−1.56K

Strike price

133.65

Held after

0.00

Exercisable

—

11/20/2025

Stock Option (Right to Buy)

Direct

M · Option Exercise

Converts to

Common Stock

2.68K shares

−2.68K

Strike price

43.37

Held after

9.32K

Exercisable

—

11/20/2025

Stock Option (Right to Buy)

Direct

M · Option Exercise

Converts to

Common Stock

207.00 shares

−207.00

Strike price

44.40

Held after

0.00

Exercisable

—

11/20/2025

Stock Option (Right to Buy)

Direct

M · Option Exercise

Converts to

Common Stock

2.35K shares

−2.35K

Strike price

44.40

Held after

981.00

Exercisable

—

11/20/2025

Stock Option (Right to Buy)

Direct

M · Option Exercise

Converts to

Common Stock

5.25K shares

−5.25K

Strike price

56.94

Held after

11.38K

Exercisable

—

11/20/2025

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Stock Option (Right to Buy) Direct	Common Stock1.05K shares	11/20/2025	M · Option Exercise	−1.05K	49.50	—	0.00
Stock Option (Right to Buy) Direct	Common Stock508.00 shares	11/20/2025	M · Option Exercise	−508.00	83.85	—	0.00
Stock Option (Right to Buy) Direct	Common Stock1.56K shares	11/20/2025	M · Option Exercise	−1.56K	133.65	—	0.00
Stock Option (Right to Buy) Direct	Common Stock2.68K shares	11/20/2025	M · Option Exercise	−2.68K	43.37	—	9.32K
Stock Option (Right to Buy) Direct	Common Stock207.00 shares	11/20/2025	M · Option Exercise	−207.00	44.40	—	0.00
Stock Option (Right to Buy) Direct	Common Stock2.35K shares	11/20/2025	M · Option Exercise	−2.35K	44.40	—	981.00
Stock Option (Right to Buy) Direct	Common Stock5.25K shares	11/20/2025	M · Option Exercise	−5.25K	56.94	—	11.38K