MACKANESS JAMES H (Chief Financial Officer) sold 46.3% of their position (90.62K shares) of SOLENO THERAPEUTICS INC on the open market

Open‑market sale worth $6.29M — a major position exit. Review remaining holdings and any 10b5‑1 plan disclosures.

S · 11 sales

MACKANESS JAMES H

Filed: 3/31/2025ACC: 0001415889-25-009295

InsiderMACKANESS JAMES HCIK 1422484

→

IssuerSOLENO THERAPEUTICS INCCIK 1484565

Officer· Chief Financial Officer

Since Nov 2019

-90.62K

Net shares

Net seller

$6.29M

Total sold

Open market trades

0B · 11S

Total transactions

70K acquired · 160.62K disposed

Non-Derivative Transactions16

Common Stock

Direct

S · Sale

−1.67K

Price / share

$65.97

Trade value

$110.10K

% of position

1.3%

3/27/2025

125.80K→124.13K

Common Stock

Direct

S · Sale

−2.72K

Price / share

$66.79

Trade value

$181.47K

% of position

2.2%

3/27/2025

124.13K→121.41K

Common Stock

Direct

S · Sale

−4.94K

Price / share

$67.70

Trade value

$334.44K

% of position

4.1%

3/27/2025

121.41K→116.47K

Common Stock

Direct

S · Sale

−6.50K

Price / share

$68.79

Trade value

$446.99K

% of position

5.6%

3/27/2025

116.47K→109.97K

Common Stock

Direct

S · Sale

−3.76K

Price / share

$69.84

Trade value

$262.73K

% of position

3.4%

3/27/2025

109.97K→106.21K

Common Stock

Direct

S · Sale

−387.00

Price / share

$70.73

Trade value

$27.37K

% of position

0.4%

3/27/2025

106.21K→105.83K

Common Stock

Direct

S · Sale

−563.00

Price / share

$71.74

Trade value

$40.39K

% of position

0.5%

3/27/2025

105.83K→105.26K

Common Stock

Direct

S · Sale

−86.00

Price / share

$72.64

Trade value

$6.25K

% of position

0.1%

3/27/2025

105.26K→105.18K

Common Stock

Direct

M · Option Exercise

+20K

Price / share

$30.75

Trade value

$615K

% of position

19.0%

3/27/2025

105.18K→125.18K

Common Stock

Direct

M · Option Exercise

+10K

Price / share

$5.10

Trade value

$51K

% of position

8.0%

3/27/2025

125.18K→135.18K

Common Stock

Direct

M · Option Exercise

+5K

Price / share

$2.60

Trade value

$12.98K

% of position

3.7%

3/27/2025

135.18K→140.18K

Common Stock

Direct

M · Option Exercise

+15K

Price / share

$2.41

Trade value

$36.15K

% of position

10.7%

3/27/2025

140.18K→155.18K

Common Stock

Direct

M · Option Exercise

+20K

Price / share

$5.25

Trade value

$105K

% of position

12.9%

3/27/2025

155.18K→175.18K

Common Stock

Direct

S · Sale

−25.80K

Price / share

$69.07

Trade value

$1.78M

% of position

14.7%

3/27/2025

175.18K→149.38K

Common Stock

Direct

S · Sale

−36.16K

Price / share

$70.03

Trade value

$2.53M

% of position

24.2%

3/27/2025

149.38K→113.22K

Common Stock

Direct

S · Sale

−8.04K

Price / share

$70.80

Trade value

$569.49K

% of position

7.1%

3/27/2025

113.22K→105.18K

Total

Net shares

−20.62K

Net value

-$5.47M

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Direct	3/27/2025	S · Sale	−1.67K	$65.97	$110.10K	1.3%	125.80K	124.13K
Common Stock Direct	3/27/2025	S · Sale	−2.72K	$66.79	$181.47K	2.2%	124.13K	121.41K
Common Stock Direct	3/27/2025	S · Sale	−4.94K	$67.70	$334.44K	4.1%	121.41K	116.47K
Common Stock Direct	3/27/2025	S · Sale	−6.50K	$68.79	$446.99K	5.6%	116.47K	109.97K
Common Stock Direct	3/27/2025	S · Sale	−3.76K	$69.84	$262.73K	3.4%	109.97K	106.21K
Common Stock Direct	3/27/2025	S · Sale	−387.00	$70.73	$27.37K	0.4%	106.21K	105.83K
Common Stock Direct	3/27/2025	S · Sale	−563.00	$71.74	$40.39K	0.5%	105.83K	105.26K
Common Stock Direct	3/27/2025	S · Sale	−86.00	$72.64	$6.25K	0.1%	105.26K	105.18K
Common Stock Direct	3/27/2025	M · Option Exercise	+20K	$30.75	$615K	19.0%	105.18K	125.18K
Common Stock Direct	3/27/2025	M · Option Exercise	+10K	$5.10	$51K	8.0%	125.18K	135.18K
Common Stock Direct	3/27/2025	M · Option Exercise	+5K	$2.60	$12.98K	3.7%	135.18K	140.18K
Common Stock Direct	3/27/2025	M · Option Exercise	+15K	$2.41	$36.15K	10.7%	140.18K	155.18K
Common Stock Direct	3/27/2025	M · Option Exercise	+20K	$5.25	$105K	12.9%	155.18K	175.18K
Common Stock Direct	3/27/2025	S · Sale	−25.80K	$69.07	$1.78M	14.7%	175.18K	149.38K
Common Stock Direct	3/27/2025	S · Sale	−36.16K	$70.03	$2.53M	24.2%	149.38K	113.22K
Common Stock Direct	3/27/2025	S · Sale	−8.04K	$70.80	$569.49K	7.1%	113.22K	105.18K
Total			−20.62K		-$5.47M

Derivative Transactions5

Employee stock option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

20K shares

−20K

Strike price

30.75

Held after

0.00

Exercisable

—

3/27/2025

Employee stock option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

10K shares

−10K

Strike price

5.10

Held after

Exercisable

—

3/27/2025

Employee stock option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

5K shares

−5K

Strike price

2.595

Held after

0.00

Exercisable

—

3/27/2025

Employee stock option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

15K shares

−15K

Strike price

2.41

Held after

15K

Exercisable

—

3/27/2025

Employee stock option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

20K shares

−20K

Strike price

5.25

Held after

67.25K

Exercisable

—

3/27/2025

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Employee stock option (right to buy) Direct	Common Stock20K shares	3/27/2025	M · Option Exercise	−20K	30.75	—	0.00
Employee stock option (right to buy) Direct	Common Stock10K shares	3/27/2025	M · Option Exercise	−10K	5.10	—	3K
Employee stock option (right to buy) Direct	Common Stock5K shares	3/27/2025	M · Option Exercise	−5K	2.595	—	0.00
Employee stock option (right to buy) Direct	Common Stock15K shares	3/27/2025	M · Option Exercise	−15K	2.41	—	15K
Employee stock option (right to buy) Direct	Common Stock20K shares	3/27/2025	M · Option Exercise	−20K	5.25	—	67.25K