LEPROUST EMILY M. (President & CEO) sold 36.5% of their position (356.55K shares) of TWIST BIOSCIENCE CORP on the open market

Open‑market sale worth $56.33M — a major position exit. Review remaining holdings and any 10b5‑1 plan disclosures.

S · 13 sales

LEPROUST EMILY M.

Filed: 9/21/2026ACC: 0001214659-26-011832

InsiderLEPROUST EMILY M.CIK 1753655

→

IssuerTWIST BIOSCIENCE CORPCIK 1581280

DirectorOfficer· President & CEO

Since Oct 2018

-356.55K

Net shares

Net seller

$56.33M

Total sold

Open market trades

0B · 13S

Total transactions

208.71K acquired · 565.25K disposed

Non-Derivative Transactions15

Common Stock

Direct

M · Option Exercise

+133.27K

Price / share

$26.66

Trade value

$3.55M

% of position

17.3%

9/17/2026

768.43K→901.70K

Common Stock

Direct

M · Option Exercise

+75.44K

Price / share

$8.82

Trade value

$665.37K

% of position

8.4%

9/17/2026

901.70K→977.13K

Common Stock

Direct

S · Sale

−2.44K

Price / share

$151.46

Trade value

$369.57K

% of position

0.2%

9/17/2026

977.13K→974.70K

Common Stock

Direct

S · Sale

−6.64K

Price / share

$152.21

Trade value

$1.01M

% of position

0.7%

9/17/2026

974.70K→968.05K

Common Stock

Direct

S · Sale

−3.40K

Price / share

$153.40

Trade value

$521.42K

% of position

0.4%

9/17/2026

968.05K→964.65K

Common Stock

Direct

S · Sale

−4.17K

Price / share

$154.17

Trade value

$643.66K

% of position

0.4%

9/17/2026

964.65K→960.48K

Common Stock

Direct

S · Sale

−13.38K

Price / share

$155.46

Trade value

$2.08M

% of position

1.4%

9/17/2026

960.48K→947.10K

Common Stock

Direct

S · Sale

−9.10K

Price / share

$156.47

Trade value

$1.42M

% of position

1.0%

9/17/2026

947.10K→938K

Common Stock

Direct

S · Sale

−32.26K

Price / share

$157.49

Trade value

$5.08M

% of position

3.4%

9/17/2026

938K→905.74K

Common Stock

Direct

S · Sale

−232.17K

Price / share

$158.09

Trade value

$36.70M

% of position

25.6%

9/17/2026

905.74K→673.57K

Common Stock

Direct

S · Sale

−23.88K

Price / share

$159.53

Trade value

$3.81M

% of position

3.5%

9/17/2026

673.57K→649.68K

Common Stock

Direct

S · Sale

−14.49K

Price / share

$160.44

Trade value

$2.33M

% of position

2.2%

9/17/2026

649.68K→635.19K

Common Stock

Direct

S · Sale

−11.17K

Price / share

$161.49

Trade value

$1.80M

% of position

1.8%

9/17/2026

635.19K→624.02K

Common Stock

Direct

S · Sale

−2.56K

Price / share

$162.31

Trade value

$416.33K

% of position

0.4%

9/17/2026

624.02K→621.46K

Common Stock

Direct

S · Sale

−869.00

Price / share

$163.39

Trade value

$141.99K

% of position

0.1%

9/17/2026

621.46K→620.59K

Total

Net shares

−147.84K

Net value

-$52.11M

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Direct	9/17/2026	M · Option Exercise	+133.27K	$26.66	$3.55M	17.3%	768.43K	901.70K
Common Stock Direct	9/17/2026	M · Option Exercise	+75.44K	$8.82	$665.37K	8.4%	901.70K	977.13K
Common Stock Direct	9/17/2026	S · Sale	−2.44K	$151.46	$369.57K	0.2%	977.13K	974.70K
Common Stock Direct	9/17/2026	S · Sale	−6.64K	$152.21	$1.01M	0.7%	974.70K	968.05K
Common Stock Direct	9/17/2026	S · Sale	−3.40K	$153.40	$521.42K	0.4%	968.05K	964.65K
Common Stock Direct	9/17/2026	S · Sale	−4.17K	$154.17	$643.66K	0.4%	964.65K	960.48K
Common Stock Direct	9/17/2026	S · Sale	−13.38K	$155.46	$2.08M	1.4%	960.48K	947.10K
Common Stock Direct	9/17/2026	S · Sale	−9.10K	$156.47	$1.42M	1.0%	947.10K	938K
Common Stock Direct	9/17/2026	S · Sale	−32.26K	$157.49	$5.08M	3.4%	938K	905.74K
Common Stock Direct	9/17/2026	S · Sale	−232.17K	$158.09	$36.70M	25.6%	905.74K	673.57K
Common Stock Direct	9/17/2026	S · Sale	−23.88K	$159.53	$3.81M	3.5%	673.57K	649.68K
Common Stock Direct	9/17/2026	S · Sale	−14.49K	$160.44	$2.33M	2.2%	649.68K	635.19K
Common Stock Direct	9/17/2026	S · Sale	−11.17K	$161.49	$1.80M	1.8%	635.19K	624.02K
Common Stock Direct	9/17/2026	S · Sale	−2.56K	$162.31	$416.33K	0.4%	624.02K	621.46K
Common Stock Direct	9/17/2026	S · Sale	−869.00	$163.39	$141.99K	0.1%	621.46K	620.59K
Total			−147.84K		-$52.11M

Derivative Transactions2

Employee Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

75.44K shares

−75.44K

Strike price

8.82

Held after

0.00

Exercisable

—

9/17/2026

Employee Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

133.27K shares

−133.27K

Strike price

26.66

Held after

0.00

Exercisable

—

9/17/2026

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Employee Stock Option (right to buy) Direct	Common Stock75.44K shares	9/17/2026	M · Option Exercise	−75.44K	8.82	—	0.00
Employee Stock Option (right to buy) Direct	Common Stock133.27K shares	9/17/2026	M · Option Exercise	−133.27K	26.66	—	0.00

Non-Derivative Holdings (Post-Transaction)0

No non-derivative holdings reported

Derivative Holdings (Post-Transaction)3

Employee Stock Option (right to buy)

Direct

Underlying security

Common Stock

Underlying shares

0.00

Shares owned

0.00

Exercise price

5.95

Expiration

—

Exercise window

—

Employee Stock Option (right to buy)

Direct

Underlying security

Common Stock

Underlying shares

64.95K

Shares owned

64.95K

Exercise price

67.85

Expiration

—

Exercise window

—

Employee Stock Option (right to buy)

Direct

Underlying security

Common Stock

Underlying shares

131.29K

Shares owned

131.29K

Exercise price

23.33

Expiration

—

Exercise window

—

Total

Underlying

196.24K

Owned

196.24K

Security	Underlying	Exercise Price	Exercise Window	Expiration	Underlying Shares	Shares Owned
Employee Stock Option (right to buy) Direct	Common Stock	5.95	—	—	0.00	0.00
Employee Stock Option (right to buy) Direct	Common Stock	67.85	—	—	64.95K	64.95K
Employee Stock Option (right to buy) Direct	Common Stock	23.33	—	—	131.29K	131.29K
Total					196.24K	196.24K