LEPROUST EMILY M. (President & CEO) sold 5.5% of their position (49.30K shares) of TWIST BIOSCIENCE CORP on the open market

Open‑market sale worth $3.21M — a moderate reduction. Review remaining holdings and any 10b5‑1 plan disclosures.

S · 3 sales

LEPROUST EMILY M.

Filed: 5/28/2026ACC: 0001214659-26-006835

InsiderLEPROUST EMILY M.CIK 1753655

→

IssuerTWIST BIOSCIENCE CORPCIK 1581280

DirectorOfficer· President & CEO

Since Oct 2018

+49.30K

Net shares

Net buyer

$3.21M

Total sold

Open market trades

0B · 3S

Total transactions

98.60K acquired · 49.30K disposed

Non-Derivative Transactions5

Common Stock

Direct

M · Option Exercise

+24.28K

Price / share

$8.82

Trade value

$214.17K

% of position

2.9%

5/26/2026

846.87K→871.15K

Common Stock

Direct

S · Sale

−24.28K

Price / share

$65.08

Trade value

$1.58M

% of position

2.8%

5/26/2026

871.15K→846.87K

Common Stock

Direct

M · Option Exercise

+25.02K

Price / share

$8.82

Trade value

$220.65K

% of position

3.0%

5/27/2026

846.87K→871.89K

Common Stock

Direct

S · Sale

−23.75K

Price / share

$65.24

Trade value

$1.55M

% of position

2.7%

5/27/2026

871.89K→848.14K

Common Stock

Direct

S · Sale

−1.26K

Price / share

$66.28

Trade value

$83.85K

% of position

0.1%

5/27/2026

848.14K→846.87K

Total

Net shares

+0.00

Net value

-$2.78M

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Direct	5/26/2026	M · Option Exercise	+24.28K	$8.82	$214.17K	2.9%	846.87K	871.15K
Common Stock Direct	5/26/2026	S · Sale	−24.28K	$65.08	$1.58M	2.8%	871.15K	846.87K
Common Stock Direct	5/27/2026	M · Option Exercise	+25.02K	$8.82	$220.65K	3.0%	846.87K	871.89K
Common Stock Direct	5/27/2026	S · Sale	−23.75K	$65.24	$1.55M	2.7%	871.89K	848.14K
Common Stock Direct	5/27/2026	S · Sale	−1.26K	$66.28	$83.85K	0.1%	848.14K	846.87K
Total			+0.00		-$2.78M

Derivative Transactions2

Employee Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

24.28K shares

+24.28K

Strike price

8.82

Held after

116.93K

Exercisable

—

5/26/2026

Employee Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

25.02K shares

+25.02K

Strike price

8.82

Held after

91.91K

Exercisable

—

5/27/2026

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Employee Stock Option (right to buy) Direct	Common Stock24.28K shares	5/26/2026	M · Option Exercise	+24.28K	8.82	—	116.93K
Employee Stock Option (right to buy) Direct	Common Stock25.02K shares	5/27/2026	M · Option Exercise	+25.02K	8.82	—	91.91K

Non-Derivative Holdings (Post-Transaction)0

No non-derivative holdings reported

Derivative Holdings (Post-Transaction)4

Employee Stock Option (right to buy)

Direct

Underlying security

Common Stock

Underlying shares

0.00

Shares owned

0.00

Exercise price

5.95

Expiration

—

Exercise window

—

Employee Stock Option (right to buy)

Direct

Underlying security

Common Stock

Underlying shares

64.95K

Shares owned

64.95K

Exercise price

67.85

Expiration

—

Exercise window

—

Employee Stock Option (right to buy)

Direct

Underlying security

Common Stock

Underlying shares

0.00

Shares owned

131.29K

Exercise price

23.33

Expiration

—

Exercise window

—

Employee Stock Option (right to buy)

Direct

Underlying security

Common Stock

Underlying shares

0.00

Shares owned

266.54K

Exercise price

26.66

Expiration

—

Exercise window

—

Total

Underlying

64.95K

Owned

462.78K

Security	Underlying	Exercise Price	Exercise Window	Expiration	Underlying Shares	Shares Owned
Employee Stock Option (right to buy) Direct	Common Stock	5.95	—	—	0.00	0.00
Employee Stock Option (right to buy) Direct	Common Stock	67.85	—	—	64.95K	64.95K
Employee Stock Option (right to buy) Direct	Common Stock	23.33	—	—	0.00	131.29K
Employee Stock Option (right to buy) Direct	Common Stock	26.66	—	—	0.00	266.54K
Total					64.95K	462.78K