LEPROUST EMILY M. (President & CEO) sold 1.1% of their position (9.67K shares) of TWIST BIOSCIENCE CORP on the open market

Open‑market sale worth $631.0K — a minor trim. Review remaining holdings and any 10b5‑1 plan disclosures.

S · 3 sales

LEPROUST EMILY M.

Filed: 4/23/2026ACC: 0001214659-26-005005

InsiderLEPROUST EMILY M.CIK 1753655

→

IssuerTWIST BIOSCIENCE CORPCIK 1581280

DirectorOfficer· President & CEO

Since Oct 2018

+9.67K

Net shares

Net buyer

$631.0K

Total sold

Open market trades

0B · 3S

Total transactions

19.34K acquired · 9.67K disposed

Non-Derivative Transactions5

Common Stock

Direct

M · Option Exercise

+1.61K

Price / share

$8.82

Trade value

$14.20K

% of position

0.2%

4/21/2026

858.89K→860.50K

Common Stock

Direct

S · Sale

−1.61K

Price / share

$65.01

Trade value

$104.67K

% of position

0.2%

4/21/2026

860.50K→858.89K

Common Stock

Direct

M · Option Exercise

+8.06K

Price / share

$8.82

Trade value

$71.10K

% of position

0.9%

4/22/2026

858.89K→866.95K

Common Stock

Direct

S · Sale

−7.91K

Price / share

$65.28

Trade value

$516.33K

% of position

0.9%

4/22/2026

866.95K→859.04K

Common Stock

Direct

S · Sale

−151.00

Price / share

$66.00

Trade value

$9.97K

% of position

0.0%

4/22/2026

859.04K→858.89K

Total

Net shares

+0.00

Net value

-$545.66K

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Direct	4/21/2026	M · Option Exercise	+1.61K	$8.82	$14.20K	0.2%	858.89K	860.50K
Common Stock Direct	4/21/2026	S · Sale	−1.61K	$65.01	$104.67K	0.2%	860.50K	858.89K
Common Stock Direct	4/22/2026	M · Option Exercise	+8.06K	$8.82	$71.10K	0.9%	858.89K	866.95K
Common Stock Direct	4/22/2026	S · Sale	−7.91K	$65.28	$516.33K	0.9%	866.95K	859.04K
Common Stock Direct	4/22/2026	S · Sale	−151.00	$66.00	$9.97K	0.0%	859.04K	858.89K
Total			+0.00		-$545.66K

Derivative Transactions2

Employee Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

1.61K shares

+1.61K

Strike price

8.82

Held after

149.27K

Exercisable

—

4/21/2026

Employee Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

8.06K shares

+8.06K

Strike price

8.82

Held after

141.21K

Exercisable

—

4/22/2026

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Employee Stock Option (right to buy) Direct	Common Stock1.61K shares	4/21/2026	M · Option Exercise	+1.61K	8.82	—	149.27K
Employee Stock Option (right to buy) Direct	Common Stock8.06K shares	4/22/2026	M · Option Exercise	+8.06K	8.82	—	141.21K

Non-Derivative Holdings (Post-Transaction)0

No non-derivative holdings reported

Derivative Holdings (Post-Transaction)4

Employee Stock Option (right to buy)

Direct

Underlying security

Common Stock

Underlying shares

0.00

Shares owned

131.29K

Exercise price

23.33

Expiration

—

Exercise window

—

Employee Stock Option (right to buy)

Direct

Underlying security

Common Stock

Underlying shares

64.95K

Shares owned

64.95K

Exercise price

67.85

Expiration

—

Exercise window

—

Employee Stock Option (right to buy)

Direct

Underlying security

Common Stock

Underlying shares

0.00

Shares owned

0.00

Exercise price

5.95

Expiration

—

Exercise window

—

Employee Stock Option (right to buy)

Direct

Underlying security

Common Stock

Underlying shares

0.00

Shares owned

266.54K

Exercise price

26.66

Expiration

—

Exercise window

—

Total

Underlying

64.95K

Owned

462.78K

Security	Underlying	Exercise Price	Exercise Window	Expiration	Underlying Shares	Shares Owned
Employee Stock Option (right to buy) Direct	Common Stock	23.33	—	—	0.00	131.29K
Employee Stock Option (right to buy) Direct	Common Stock	67.85	—	—	64.95K	64.95K
Employee Stock Option (right to buy) Direct	Common Stock	5.95	—	—	0.00	0.00
Employee Stock Option (right to buy) Direct	Common Stock	26.66	—	—	0.00	266.54K
Total					64.95K	462.78K