LEIDEN JEFFREY M (Executive Chairman) sold 75.3% of their position (73.29K shares) of VERTEX PHARMACEUTICALS INC / MA on the open market

Open‑market sale worth $32.29M — a major position exit. Review remaining holdings and any 10b5‑1 plan disclosures.

S · 5 sales

LEIDEN JEFFREY M

Filed: 11/17/2025ACC: 0000875320-25-000234

InsiderLEIDEN JEFFREY MCIK 1242825

→

IssuerVERTEX PHARMACEUTICALS INC / MACIK 875320

DirectorOfficer· Executive Chairman

Since Feb 2026

-73.29K

Net shares

Net seller

$32.29M

Total sold

Open market trades

0B · 5S

Total transactions

73.29K acquired · 146.58K disposed

Non-Derivative Transactions8

Common Stock

Direct

M · Option Exercise

+19.69K

Price / share

$91.05

Trade value

$1.79M

% of position

81.9%

11/13/2025

24.03K→43.71K

Common Stock

Direct

S · Sale

−18.53K

Price / share

$440.22

Trade value

$8.16M

% of position

42.4%

11/13/2025

43.71K→25.19K

Common Stock

Direct

S · Sale

−1.16K

Price / share

$441.05

Trade value

$511.62K

% of position

4.6%

11/13/2025

25.19K→24.03K

Common Stock

Direct

M · Option Exercise

+13.84K

Price / share

$91.05

Trade value

$1.26M

% of position

57.6%

11/14/2025

24.03K→37.86K

Common Stock

Direct

M · Option Exercise

+39.77K

Price / share

$86.52

Trade value

$3.44M

% of position

105.0%

11/14/2025

37.86K→77.63K

Common Stock

Direct

S · Sale

−32.23K

Price / share

$440.30

Trade value

$14.19M

% of position

41.5%

11/14/2025

77.63K→45.40K

Common Stock

Direct

S · Sale

−21.33K

Price / share

$441.35

Trade value

$9.41M

% of position

47.0%

11/14/2025

45.40K→24.07K

Common Stock

Direct

S · Sale

−40.00

Price / share

$442.00

Trade value

$17.68K

% of position

0.2%

11/14/2025

24.07K→24.03K

Total

Net shares

+0.00

Net value

-$25.80M

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Direct	11/13/2025	M · Option Exercise	+19.69K	$91.05	$1.79M	81.9%	24.03K	43.71K
Common Stock Direct	11/13/2025	S · Sale	−18.53K	$440.22	$8.16M	42.4%	43.71K	25.19K
Common Stock Direct	11/13/2025	S · Sale	−1.16K	$441.05	$511.62K	4.6%	25.19K	24.03K
Common Stock Direct	11/14/2025	M · Option Exercise	+13.84K	$91.05	$1.26M	57.6%	24.03K	37.86K
Common Stock Direct	11/14/2025	M · Option Exercise	+39.77K	$86.52	$3.44M	105.0%	37.86K	77.63K
Common Stock Direct	11/14/2025	S · Sale	−32.23K	$440.30	$14.19M	41.5%	77.63K	45.40K
Common Stock Direct	11/14/2025	S · Sale	−21.33K	$441.35	$9.41M	47.0%	45.40K	24.07K
Common Stock Direct	11/14/2025	S · Sale	−40.00	$442.00	$17.68K	0.2%	24.07K	24.03K
Total			+0.00		-$25.80M

Derivative Transactions3

Stock Option (Right to Buy)

Direct

M · Option Exercise

Converts to

Common Stock

19.69K shares

−19.69K

Strike price

91.05

Held after

13.84K

Exercisable

—

11/13/2025

Stock Option (Right to Buy)

Direct

M · Option Exercise

Converts to

Common Stock

13.84K shares

−13.84K

Strike price

91.05

Held after

1.00

Exercisable

—

11/14/2025

Stock Option (Right to Buy)

Direct

M · Option Exercise

Converts to

Common Stock

39.77K shares

−39.77K

Strike price

86.52

Held after

63.78K

Exercisable

—

11/14/2025

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Stock Option (Right to Buy) Direct	Common Stock19.69K shares	11/13/2025	M · Option Exercise	−19.69K	91.05	—	13.84K
Stock Option (Right to Buy) Direct	Common Stock13.84K shares	11/14/2025	M · Option Exercise	−13.84K	91.05	—	1.00
Stock Option (Right to Buy) Direct	Common Stock39.77K shares	11/14/2025	M · Option Exercise	−39.77K	86.52	—	63.78K

Non-Derivative Holdings (Post-Transaction)1

Common Stock

Indirect

Shares owned440.00

Total

440.00 indirect440.00

Security Title	Shares Owned	Ownership Type
Common Stock	440.00	Indirect
Total	440.00	440.00 indirect

Derivative Holdings (Post-Transaction)0

No derivative holdings reported