KNIGHT JEFF E. (Chief Operating Officer) sold 44.7% of their position (85.16K shares) of CRINETICS PHARMACEUTICALS, INC. on the open market

Open‑market sale worth $3.42M — a major position exit. Review remaining holdings and any 10b5‑1 plan disclosures.

S · 1 sale

KNIGHT JEFF E.

Filed: 4/10/2026ACC: 0001628280-26-024716

InsiderKNIGHT JEFF E.CIK 1881007

→

IssuerCRINETICS PHARMACEUTICALS, INC.CIK 1658247

Officer· Chief Operating Officer

Since Aug 2021

-85.16K

Net shares

Net seller

$3.42M

Total sold

Open market trades

0B · 1S

Total transactions

78.43K acquired · 163.60K disposed

Non-Derivative Transactions4

Common Stock

Direct

M · Option Exercise

+49.47K

Price / share

$23.98

Trade value

$1.19M

% of position

44.2%

4/8/2026

112.02K→161.49K

Common Stock

Direct

M · Option Exercise

+9.62K

Price / share

$20.02

Trade value

$192.67K

% of position

6.0%

4/8/2026

161.49K→171.12K

Common Stock

Direct

M · Option Exercise

+19.34K

Price / share

$19.64

Trade value

$379.76K

% of position

11.3%

4/8/2026

171.12K→190.45K

Common Stock

Direct

S · Sale

−85.16K

Price / share

$40.10

Trade value

$3.42M

% of position

44.7%

4/8/2026

190.45K→105.29K

Total

Net shares

−6.73K

Net value

-$1.66M

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Direct	4/8/2026	M · Option Exercise	+49.47K	$23.98	$1.19M	44.2%	112.02K	161.49K
Common Stock Direct	4/8/2026	M · Option Exercise	+9.62K	$20.02	$192.67K	6.0%	161.49K	171.12K
Common Stock Direct	4/8/2026	M · Option Exercise	+19.34K	$19.64	$379.76K	11.3%	171.12K	190.45K
Common Stock Direct	4/8/2026	S · Sale	−85.16K	$40.10	$3.42M	44.7%	190.45K	105.29K
Total			−6.73K		-$1.66M

Derivative Transactions3

Stock Option (Right to Buy)

Direct

M · Option Exercise

Converts to

Common Stock

49.47K shares

−49.47K

Strike price

23.98

Held after

63.03K

Exercisable

—

4/8/2026

Stock Option (Right to Buy)

Direct

M · Option Exercise

Converts to

Common Stock

9.62K shares

−9.62K

Strike price

20.02

Held after

10.59K

Exercisable

—

4/8/2026

Stock Option (Right to Buy)

Direct

M · Option Exercise

Converts to

Common Stock

19.34K shares

−19.34K

Strike price

19.64

Held after

65.98K

Exercisable

—

4/8/2026

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Stock Option (Right to Buy) Direct	Common Stock49.47K shares	4/8/2026	M · Option Exercise	−49.47K	23.98	—	63.03K
Stock Option (Right to Buy) Direct	Common Stock9.62K shares	4/8/2026	M · Option Exercise	−9.62K	20.02	—	10.59K
Stock Option (Right to Buy) Direct	Common Stock19.34K shares	4/8/2026	M · Option Exercise	−19.34K	19.64	—	65.98K