KING-JONES HEIDY (See Remarks) sold 90.9% of their position (28.40K shares) of SPYRE THERAPEUTICS, INC. on the open market

Open‑market sale worth $2.48M — a major position exit. Review remaining holdings and any 10b5‑1 plan disclosures.

S · 5 sales

KING-JONES HEIDY

Filed: 9/4/2026ACC: 0001636282-26-000111

InsiderKING-JONES HEIDYCIK 1794898

→

IssuerSPYRE THERAPEUTICS, INC.CIK 1636282

Officer· See Remarks

Since Sep 2023

-28.40K

Net shares

Net seller

$2.48M

Total sold

Open market trades

0B · 5S

Total transactions

28.40K acquired · 56.80K disposed

Non-Derivative Transactions7

Common Stock

Direct

M · Option Exercise

+28K

Price / share

$14.50

Trade value

$405.99K

% of position

984.1%

9/1/2026

2.85K→30.84K

Common Stock

Direct

S · Sale

−4.84K

Price / share

$86.40

Trade value

$418.61K

% of position

15.7%

9/1/2026

30.84K→26K

Common Stock

Direct

S · Sale

−16.55K

Price / share

$87.20

Trade value

$1.44M

% of position

63.6%

9/1/2026

26K→9.45K

Common Stock

Direct

S · Sale

−6.21K

Price / share

$88.17

Trade value

$547.18K

% of position

65.7%

9/1/2026

9.45K→3.25K

Common Stock

Direct

S · Sale

−400.00

Price / share

$89.38

Trade value

$35.75K

% of position

12.3%

9/1/2026

3.25K→2.85K

Common Stock

Direct

M · Option Exercise

+400.00

Price / share

$14.50

Trade value

$5.80K

% of position

14.1%

9/2/2026

2.85K→3.25K

Common Stock

Direct

S · Sale

−400.00

Price / share

$90.00

Trade value

$36K

% of position

12.3%

9/2/2026

3.25K→2.85K

Total

Net shares

+0.00

Net value

-$2.07M

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Direct	9/1/2026	M · Option Exercise	+28K	$14.50	$405.99K	984.1%	2.85K	30.84K
Common Stock Direct	9/1/2026	S · Sale	−4.84K	$86.40	$418.61K	15.7%	30.84K	26K
Common Stock Direct	9/1/2026	S · Sale	−16.55K	$87.20	$1.44M	63.6%	26K	9.45K
Common Stock Direct	9/1/2026	S · Sale	−6.21K	$88.17	$547.18K	65.7%	9.45K	3.25K
Common Stock Direct	9/1/2026	S · Sale	−400.00	$89.38	$35.75K	12.3%	3.25K	2.85K
Common Stock Direct	9/2/2026	M · Option Exercise	+400.00	$14.50	$5.80K	14.1%	2.85K	3.25K
Common Stock Direct	9/2/2026	S · Sale	−400.00	$90.00	$36K	12.3%	3.25K	2.85K
Total			+0.00		-$2.07M

Derivative Transactions2

Stock Option (Right to Buy)

Direct

M · Option Exercise

Converts to

Common Stock

28K shares

−28K

Strike price

14.50

Held after

511.81K

Exercisable

—

9/1/2026

Stock Option (Right to Buy)

Direct

M · Option Exercise

Converts to

Common Stock

400.00 shares

−400.00

Strike price

14.50

Held after

511.41K

Exercisable

—

9/2/2026

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Stock Option (Right to Buy) Direct	Common Stock28K shares	9/1/2026	M · Option Exercise	−28K	14.50	—	511.81K
Stock Option (Right to Buy) Direct	Common Stock400.00 shares	9/2/2026	M · Option Exercise	−400.00	14.50	—	511.41K