Filed: 11/14/2025ACC: 0001814554-25-000164
📋 What this filing means
GREAT POINT PARTNERS LLC filed this quarterly 13F‑HR report disclosing 30 equity positions with a total reported market value of $242.50M. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
30
Positions
$242.50M
Total AUM (reported)
23.23M
Total Shares
Allocation by class
COM$242.50M100.0%
Portfolio Concentration
Top 3$63.22M26.1%
4–10$90.16M37.2%
11–25$79.98M33.0%
Rest$9.14M3.8%
Top 3 weight
26.1%
Top 10 weight
63.3%
Voting Authority Distribution
Total shares with voting rights: 23.23M
Sole
Full voting authority
0.00
shares
% of voting shares0.0%
Shared
Joint voting authority
23.23M
shares
% of voting shares100.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole0
Shared0
Other30
Dominant voting typeShared · 100.0% of voting shares
Institutional Holdings30
Rows:
AMYLYX PHARMACEUTICALS INC
DFNDShares1.70M
TypeSH
Market value$23.10M
9.53%
Sole
0.00
Shared
1.70M
None
0.00
REZOLUTE INC COM NEW
DFNDShares2.45M
TypeSH
Market value$23.05M
9.50%
Sole
0.00
Shared
2.45M
None
0.00
NEKTAR THERAPEUTICS COM NEW
DFNDShares300K
TypeSH
Market value$17.07M
7.04%
Sole
0.00
Shared
300K
None
0.00
ZURA BIO LTD CLASS A ORD SHS
DFNDShares3.82M
TypeSH
Market value$16.52M
6.81%
Sole
0.00
Shared
3.82M
None
0.00
SOLENO THERAPEUTICS INC
DFNDShares225K
TypeSH
Market value$15.21M
6.27%
Sole
0.00
Shared
225K
None
0.00
ASCENDIS PHARMA A/S SPONSORED ADR
DFNDShares75K
TypeSH
Market value$14.91M
6.15%
Sole
0.00
Shared
75K
None
0.00
ABIVAX SA SPONSORED ADS
DFNDShares150K
TypeSH
Market value$12.73M
5.25%
Sole
0.00
Shared
150K
None
0.00
APOGEE THERAPEUTICS INC
DFNDShares304K
TypeSH
Market value$12.08M
4.98%
Sole
0.00
Shared
304K
None
0.00
DIANTHUS THERAPEUTICS INC
DFNDShares265.80K
TypeSH
Market value$10.46M
4.31%
Sole
0.00
Shared
265.80K
None
0.00
CYTOKINETICS INC COM NEW
DFNDShares150K
TypeSH
Market value$8.24M
3.40%
Sole
0.00
Shared
150K
None
0.00
IMMUNOVANT INC
DFNDShares500K
TypeSH
Market value$8.06M
3.32%
Sole
0.00
Shared
500K
None
0.00
XENON PHARMACEUTICALS INC
DFNDShares200K
TypeSH
Market value$8.03M
3.31%
Sole
0.00
Shared
200K
None
0.00
NEUROGENE INC
DFNDShares446.81K
TypeSH
Market value$7.74M
3.19%
Sole
0.00
Shared
446.81K
None
0.00
EUPRAXIA PHARMACEUTICALS INC
DFNDShares1.20M
TypeSH
Market value$7.08M
2.92%
Sole
0.00
Shared
1.20M
None
0.00
UPSTREAM BIO INC
DFNDShares300K
TypeSH
Market value$5.64M
2.33%
Sole
0.00
Shared
300K
None
0.00
JADE BIOSCIENCES INC COM NEW
DFNDShares632.60K
TypeSH
Market value$5.46M
2.25%
Sole
0.00
Shared
632.60K
None
0.00
IONIS PHARMACEUTICALS INC
DFNDShares80K
TypeSH
Market value$5.23M
2.16%
Sole
0.00
Shared
80K
None
0.00
AKERO THERAPEUTICS INC
DFNDShares103.85K
TypeSH
Market value$4.93M
2.03%
Sole
0.00
Shared
103.85K
None
0.00
TAYSHA GENE THERAPIES INC COM SHS
DFNDShares1.50M
TypeSH
Market value$4.91M
2.02%
Sole
0.00
Shared
1.50M
None
0.00
CONTEXT THERAPEUTICS INC
DFNDShares4.68M
TypeSH
Market value$4.54M
1.87%
Sole
0.00
Shared
4.68M
None
0.00
PHARVARIS N V
DFNDShares155.10K
TypeSH
Market value$3.87M
1.60%
Sole
0.00
Shared
155.10K
None
0.00
DBV TECHNOLOGIES S A SPONSORED ADS
DFNDShares378.59K
TypeSH
Market value$3.79M
1.56%
Sole
0.00
Shared
378.59K
None
0.00
LEGEND BIOTECH CORP SPONSORED ADS
DFNDShares113.46K
TypeSH
Market value$3.70M
1.53%
Sole
0.00
Shared
113.46K
None
0.00
ORUKA THERAPEUTICS INC
DFNDShares183.33K
TypeSH
Market value$3.53M
1.45%
Sole
0.00
Shared
183.33K
None
0.00
UNICYCIVE THERAPEUTICS INC COM NEW
DFNDShares796.56K
TypeSH
Market value$3.47M
1.43%
Sole
0.00
Shared
796.56K
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
AMYLYX PHARMACEUTICALS INCDFND | COM | 1.70M | SH | $23.10M 9.53% | 0.00 | 1.70M | 0.00 |
REZOLUTE INC COM NEWDFND | COM | 2.45M | SH | $23.05M 9.50% | 0.00 | 2.45M | 0.00 |
NEKTAR THERAPEUTICS COM NEWDFND | COM | 300K | SH | $17.07M 7.04% | 0.00 | 300K | 0.00 |
ZURA BIO LTD CLASS A ORD SHSDFND | COM | 3.82M | SH | $16.52M 6.81% | 0.00 | 3.82M | 0.00 |
SOLENO THERAPEUTICS INCDFND | COM | 225K | SH | $15.21M 6.27% | 0.00 | 225K | 0.00 |
ASCENDIS PHARMA A/S SPONSORED ADRDFND | COM | 75K | SH | $14.91M 6.15% | 0.00 | 75K | 0.00 |
ABIVAX SA SPONSORED ADSDFND | COM | 150K | SH | $12.73M 5.25% | 0.00 | 150K | 0.00 |
APOGEE THERAPEUTICS INCDFND | COM | 304K | SH | $12.08M 4.98% | 0.00 | 304K | 0.00 |
DIANTHUS THERAPEUTICS INCDFND | COM | 265.80K | SH | $10.46M 4.31% | 0.00 | 265.80K | 0.00 |
CYTOKINETICS INC COM NEWDFND | COM | 150K | SH | $8.24M 3.40% | 0.00 | 150K | 0.00 |
IMMUNOVANT INCDFND | COM | 500K | SH | $8.06M 3.32% | 0.00 | 500K | 0.00 |
XENON PHARMACEUTICALS INCDFND | COM | 200K | SH | $8.03M 3.31% | 0.00 | 200K | 0.00 |
NEUROGENE INCDFND | COM | 446.81K | SH | $7.74M 3.19% | 0.00 | 446.81K | 0.00 |
EUPRAXIA PHARMACEUTICALS INCDFND | COM | 1.20M | SH | $7.08M 2.92% | 0.00 | 1.20M | 0.00 |
UPSTREAM BIO INCDFND | COM | 300K | SH | $5.64M 2.33% | 0.00 | 300K | 0.00 |
JADE BIOSCIENCES INC COM NEWDFND | COM | 632.60K | SH | $5.46M 2.25% | 0.00 | 632.60K | 0.00 |
IONIS PHARMACEUTICALS INCDFND | COM | 80K | SH | $5.23M 2.16% | 0.00 | 80K | 0.00 |
AKERO THERAPEUTICS INCDFND | COM | 103.85K | SH | $4.93M 2.03% | 0.00 | 103.85K | 0.00 |
TAYSHA GENE THERAPIES INC COM SHSDFND | COM | 1.50M | SH | $4.91M 2.02% | 0.00 | 1.50M | 0.00 |
CONTEXT THERAPEUTICS INCDFND | COM | 4.68M | SH | $4.54M 1.87% | 0.00 | 4.68M | 0.00 |
PHARVARIS N VDFND | COM | 155.10K | SH | $3.87M 1.60% | 0.00 | 155.10K | 0.00 |
DBV TECHNOLOGIES S A SPONSORED ADSDFND | COM | 378.59K | SH | $3.79M 1.56% | 0.00 | 378.59K | 0.00 |
LEGEND BIOTECH CORP SPONSORED ADSDFND | COM | 113.46K | SH | $3.70M 1.53% | 0.00 | 113.46K | 0.00 |
ORUKA THERAPEUTICS INCDFND | COM | 183.33K | SH | $3.53M 1.45% | 0.00 | 183.33K | 0.00 |
UNICYCIVE THERAPEUTICS INC COM NEWDFND | COM | 796.56K | SH | $3.47M 1.43% | 0.00 | 796.56K | 0.00 |
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