GONCALVES JOANA (Chief Medical Officer) sold 20.0% of their position (7.95K shares) of ORUKA THERAPEUTICS, INC. on the open market

Open‑market sale worth $734.1K — a significant reduction. Review remaining holdings and any 10b5‑1 plan disclosures.

S · 5 sales

GONCALVES JOANA

Filed: 9/15/2026ACC: 0000907654-26-000098

InsiderGONCALVES JOANACIK 1756991

→

IssuerORUKA THERAPEUTICS, INC.CIK 907654

Officer· Chief Medical Officer

Since Feb 2026

-7.95K

Net shares

Net seller

$734.1K

Total sold

Open market trades

0B · 5S

Total transactions

7K acquired · 14.95K disposed

Non-Derivative Transactions7

Common Stock

Direct

M · Option Exercise

+3.50K

Price / share

$6.84

Trade value

$23.94K

% of position

10.7%

9/15/2026

32.72K→36.22K

Common Stock

Direct

M · Option Exercise

+3.50K

Price / share

$7.80

Trade value

$27.30K

% of position

9.7%

9/15/2026

36.22K→39.72K

Common Stock

Direct

S · Sale

−2.38K

Price / share

$91.10

Trade value

$217.17K

% of position

6.0%

9/15/2026

39.72K→37.33K

Common Stock

Direct

S · Sale

−3.15K

Price / share

$92.03

Trade value

$289.89K

% of position

8.4%

9/15/2026

37.33K→34.18K

Common Stock

Direct

S · Sale

−1.37K

Price / share

$92.99

Trade value

$127.02K

% of position

4.0%

9/15/2026

34.18K→32.82K

Common Stock

Direct

S · Sale

−100.00

Price / share

$94.22

Trade value

$9.42K

% of position

0.3%

9/15/2026

32.82K→32.72K

Common Stock

Direct

S · Sale

−947.00

Price / share

$95.71

Trade value

$90.64K

% of position

2.9%

9/15/2026

32.72K→31.77K

Total

Net shares

−947.00

Net value

-$682.90K

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Direct	9/15/2026	M · Option Exercise	+3.50K	$6.84	$23.94K	10.7%	32.72K	36.22K
Common Stock Direct	9/15/2026	M · Option Exercise	+3.50K	$7.80	$27.30K	9.7%	36.22K	39.72K
Common Stock Direct	9/15/2026	S · Sale	−2.38K	$91.10	$217.17K	6.0%	39.72K	37.33K
Common Stock Direct	9/15/2026	S · Sale	−3.15K	$92.03	$289.89K	8.4%	37.33K	34.18K
Common Stock Direct	9/15/2026	S · Sale	−1.37K	$92.99	$127.02K	4.0%	34.18K	32.82K
Common Stock Direct	9/15/2026	S · Sale	−100.00	$94.22	$9.42K	0.3%	32.82K	32.72K
Common Stock Direct	9/15/2026	S · Sale	−947.00	$95.71	$90.64K	2.9%	32.72K	31.77K
Total			−947.00		-$682.90K

Derivative Transactions2

Employee Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

3.50K shares

−3.50K

Strike price

6.84

Held after

193.56K

Exercisable

—

9/15/2026

Employee Warrant (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

3.50K shares

−3.50K

Strike price

7.80

Held after

164.99K

Exercisable

—

9/15/2026

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Employee Stock Option (right to buy) Direct	Common Stock3.50K shares	9/15/2026	M · Option Exercise	−3.50K	6.84	—	193.56K
Employee Warrant (right to buy) Direct	Common Stock3.50K shares	9/15/2026	M · Option Exercise	−3.50K	7.80	—	164.99K