GOFF BRIAN (Chief Executive Officer) sold 9.9% of their position (18.05K shares) of AGIOS PHARMACEUTICALS, INC. on the open market

Open‑market sale worth $522.9K — a moderate reduction. Review remaining holdings and any 10b5‑1 plan disclosures.

S · 3 sales

GOFF BRIAN

Filed: 3/3/2026ACC: 0001439222-26-000044

InsiderGOFF BRIANCIK 1546216

→

IssuerAGIOS PHARMACEUTICALS, INC.CIK 1439222

DirectorOfficer· Chief Executive Officer

Since Mar 2026

+203.94K

Net shares

Net buyer

$522.9K

Total sold

Open market trades

0B · 3S

Total transactions

261.50K acquired · 57.55K disposed

Non-Derivative Transactions6

Common stock

Direct

M · Option Exercise

+8.50K

Price / share

—

Trade value

—

% of position

5.9%

3/2/2026

143.10K→151.60K

Common stock

Direct

S · Sale

−3.87K

Price / share

$28.96

Trade value

$112.08K

% of position

2.6%

3/2/2026

151.60K→147.73K

Common stock

Direct

M · Option Exercise

+18K

Price / share

—

Trade value

—

% of position

12.2%

3/2/2026

147.73K→165.73K

Common stock

Direct

S · Sale

−8.27K

Price / share

$28.96

Trade value

$239.41K

% of position

5.0%

3/2/2026

165.73K→157.47K

Common stock

Direct

M · Option Exercise

+13K

Price / share

—

Trade value

—

% of position

8.3%

3/2/2026

157.47K→170.47K

Common stock

Direct

S · Sale

−5.92K

Price / share

$28.96

Trade value

$171.39K

% of position

3.5%

3/2/2026

170.47K→164.55K

Total

Net shares

+21.45K

Net value

-$522.87K

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common stock Direct	3/2/2026	M · Option Exercise	+8.50K	—	—	5.9%	143.10K	151.60K
Common stock Direct	3/2/2026	S · Sale	−3.87K	$28.96	$112.08K	2.6%	151.60K	147.73K
Common stock Direct	3/2/2026	M · Option Exercise	+18K	—	—	12.2%	147.73K	165.73K
Common stock Direct	3/2/2026	S · Sale	−8.27K	$28.96	$239.41K	5.0%	165.73K	157.47K
Common stock Direct	3/2/2026	M · Option Exercise	+13K	—	—	8.3%	157.47K	170.47K
Common stock Direct	3/2/2026	S · Sale	−5.92K	$28.96	$171.39K	3.5%	170.47K	164.55K
Total			+21.45K		-$522.87K

Derivative Transactions5

Restricted stock units

Direct

A · Award

Converts to

Common stock

48K shares

+48K

Strike price

Held after

48K

Exercisable

—

3/1/2026

Stock options (right to buy)

Direct

A · Award

Converts to

Common stock

174K shares

+174K

Strike price

30.23

Held after

174K

Exercisable

—

3/1/2026

Restricted stock units

Direct

M · Option Exercise

Converts to

Common stock

8.50K shares

−8.50K

Strike price

Held after

0.00

Exercisable

—

3/2/2026

Restricted stock units

Direct

M · Option Exercise

Converts to

Common stock

18K shares

−18K

Strike price

Held after

18K

Exercisable

—

3/2/2026

Restricted stock units

Direct

M · Option Exercise

Converts to

Common stock

13K shares

−13K

Strike price

Held after

26K

Exercisable

—

3/2/2026

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Restricted stock units Direct	Common stock48K shares	3/1/2026	A · Award	+48K		—	48K
Stock options (right to buy) Direct	Common stock174K shares	3/1/2026	A · Award	+174K	30.23	—	174K
Restricted stock units Direct	Common stock8.50K shares	3/2/2026	M · Option Exercise	−8.50K		—	0.00
Restricted stock units Direct	Common stock18K shares	3/2/2026	M · Option Exercise	−18K		—	18K
Restricted stock units Direct	Common stock13K shares	3/2/2026	M · Option Exercise	−13K		—	26K